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| 1 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 2 | Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan显示文摘AIM:To evaluate the prevalence of Helicobacter pylori(H.pylori ) babA2 ,babB and a recombinant gene between babA2 and babB(babA2/B ),and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates.METHODS:A total of 95 continuous H.pylori-positive Costa Rican(41 males and 54 females;mean age,50.65 years;SD,± 13.04 years) and 95 continuous H.pylori-positive Japanese(50 males and 45 females;mean age,63.43;SD,± 13.21 years) patients underwent upper endoscopy from October 2005 to July 2006.They were enrolled for the polymerase chain reaction(PCR)-based genotyping of the H.pylori babA2 ,babB and babA2/B genes.Statistical analysis was performed using the χ2 test and the Fisher's exact probability test and multivariate analysis was performed by logistic regression adjusting for gender and age.P < 0.05 was regarded as statistically significant.RESULTS:The PCR-based genotyping of 95 Costa Rican and 95 Japanese isolates showed a higher prevalence of babA2 in Japan(96.8%) than in Costa Rica(73.7%),while that of babA2/B was higher in Costa Rica(11.6%) than in Japan(1.1%).In Costa Rican isolates only,babA2 was significantly associated with atrophic gastritis(P = 0.01).CONCLUSION:These results suggest that the status of babA2 and babA2/B shows geographic differences,and that babA2 has clinical relevance in Costa Rica. | Sergio A Con Hiroaki Takeuchi Mitsuaki Nishioka Norihito Morimoto Tetsuro Sugiura Nobufumi Yasuda Reinaldo Con-Wong | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 3 | Pharmacokinetic properties of E3810, a new proton pump inhibitor, in healthy male volunteers 显示文摘 | Yasuda S Ohnishi A Ogawa T | 1994 | Int J Clin Pharmacol Ther1994，32，9： | 2 |
| 4 | Generalized pustular psoriasis in Japan: two distinct groups formed by differences in symptoms and genetic background显示文摘 | Ohkawara A Yasuda H Kobayashi H | 1996 | Acta Deign Venereol1996，76，1： | 1 |
| 5 | Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma显示文摘 | Tsuchiya A Sakamoto M Yasuda J | 2003 | Am J Pathol2003，163，6： | 1 |
| 6 | Application of cationic polymer prepared from sulfuric acid lignin as a retention aid for usual rosin sizes to neutral papermaking显示文摘 | Matsusshita Y Iwatsuki A Yasuda S | 2004 | Journal of Wood Science2004，50，： | 1 |
| 7 | Role of the prenyl group on the G protein gamma subunit in coupling trimeric G proteins to aladenesine receptors显示文摘 | Yasuda H Lindorfer M A Woodfork K A | 1996 | J Biol Chem1996，271，18： | 1 |
| 8 | Induction of pro- tective immunity in animals vaccinated with recombinant vaccinia vi- ruses that express PreM and E glycoproteins of Japanese encephalitis virus 显示文摘 | Yasuda A Kimura-Kuroda J Ogimoto M | 1990 | J Virol1990，64，： | 1 |
| 9 | Surgical anatomy of microneurosurgical sulcal key points显示文摘 | Ribas GC Yasuda A Ribas EC | 2006 | Neurosurgery2006，59，42： | 1 |
| 10 | Microsurgical anatomy and approaches to the cavernous sinus显示文摘 | Yasuda A Campero A Rhoton AL | 2005 | Neurosurg2005，56，： | 1 |
| 11 | Induction of protective immunity in animals vaccinated with recombinant vaccinia viruses that express PreM and E glycoproteins of Japanese encephalitis virus 显示文摘 | Yasuda A Kimura-Kuroda J Ogimoto M | 1990 | J Virol1990，64，6： | 1 |
| 12 | Inhibitory effects of prostaglandin E1 alpha-cyclodextrig (PG E1-CD) on dinethylnitrosamine indued acute liver damage in rats 显示文摘 | Suzuki A Hagino M Yasuda N | 1995 | Nippon Yakurigaku zasshi1995，105，4： | 1 |
| 13 | The medial wall of the cavernous sinus: microsurgical anatomy显示文摘 | Yasuda A Campero A Martins C | 2004 | Ncurosurgery2004，55，1： | 1 |
| 14 | Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats显示文摘 | Yasuda H Imai E Shiota A | 1996 | Hepatology1996，24，3： | 1 |
| 15 | Microsurgical anatomy and approaches to the cavernous sinus 显示文摘 | Yasuda A Campero A Martins C | 2008 | Neurosurgery2008，62，63： | 1 |
| 16 | Cloning and Nucleotide Sequence of the Pullulanase Gene of Thermus thermophilus HB8 and Production of the Enzyme in Escherichia coli显示文摘 | Tomiyasu K Yato K Yasuda M Tonozuka T Ibuka A Sakai H | | 0，，09： | 1 |
| 17 | Association between psy- ehosoeial job characteristics and insomnia: an investigation using two relevant job stress models-the demand-control-support (DCS) model and the effort-reward imbalance (ERI) model显示文摘 | Ota A Masueb T Nobufumi Yasuda | 2005 | Sleep Med2005，6，4： | 1 |
| 18 | Research and development of superconducting fault current limiter in Japan显示文摘 | YASUDA K ICHINOSE A KIMURA A | 2005 | IEEE Trans on Appl Superconductivity2005，15，2： | 1 |
| 19 | Modular activation of nuclear factor kappaB transcriptional programs in human diabetic nephropathy显示文摘 | Schmid H Boucherot A Yasuda Y | 2006 | Diabetes2006，55，11： | 1 |
| 20 | Machanism of the sensitivity of the planar cosensor and it dependency on humidity显示文摘 | Yasuda A Doi K Yamaga N | 1992 | J Eelctrochem Soc1992，139，： | 1 |
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