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| 1 | Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells显示文摘Mannan-binding lectin(MBL)plays a key role in the lectin pathway of complement activation and can influence cytokine expression.Toll-like receptor 4(TLR4)is expressed extensively and has been demonstrated to be involved in lipopolysaccharide(LPS)-induced signaling.We first sought to determine whether MBL exposure could modulate LPS-induced inflammatory cytokine secretion and nuclear factor-kB(NF-kB)activity by using the monocytoid cell line THP-1.We then investigated the possible mechanisms underlying any observed regulatory effect.Using ELISA and reverse transcriptase polymerase chain reaction(RT-PCR)analysis,we found that at both the protein andmRNAlevels,treatment withMBLsuppresses LPS-induced tumor-necrosis factor(TNF)-a and IL-12 production in THP-1 cells.An electrophoretic mobility shift assay and western blot analysis revealed that MBL treatment can inhibit LPS-induced NF-kB DNA binding and translocation in THP-1 cells.While the binding of MBL to THP-1 cells was evident at physiological calcium concentrations,this binding occurred optimally in response to supraphysiological calcium concentrations.This binding can be partly inhibited by treatment with either a soluble form of recombinant TLR4 extracellular domain or anti-TLR4 monoclonal antibody(HTA125).Activation of THP-1 cells by LPS treatment resulted in increased MBL binding.We also observed that MBL could directly bind to the extracellular domain of TLR4 in a dose-dependent manner,and this interaction could attenuate the binding of LPS to cell surfaces.Taken together,these data suggest that MBL may affect cytokine expression through modulation of LPS-/TLR-signaling pathways.These findings suggest that MBL may play an important role in both immune regulation and the signaling pathways involved in cytokine networks. | Mingyong Wang Yue Chen Yani Zhang Liyun Zhang Xiao Lu Zhengliang Chen | 2011 | Cellular & Molecular Immunology2011，8，3： | 21 |
| 2 | Spherical nano-Sb@C composite as a high-rate and ultra-stable anode material for sodium-ion batteries显示文摘一种喷雾器水花热分解技术被用来综合球形的 nano-Sb@C 合成。仪器的分析表明与 68.8 wt% 的一个优化 Sb 内容合成的 micro-nanostructured 一致地由极端小的 Sb nanoparticles (10 nm ) 组成在一个球形的多孔的 C 矩阵以内嵌入(作为 10-Sb @ C 表示了) 。Sb 的内容和尺寸能被改变先锋的集中控制。作为钠离子电池的阳极材料, 10-Sb @ C 提供 435 mAh 据 ? 椠据畬楤杮愠猠数楣楦 ? 慣慰楣慴据 ? 景ㄠ ? 的一个分泌物能力 ? 术挠浯慰敲 ? 楷桴琠敨瘠污敵漠 ??? 术映牯 ?? 瑡愠挠慨杲 ? 楤' 湛?慲整漠 ?? ‰ ? | Ning Zhang Yongchang Liu Yanying Lu Xiaopeng Han Fangyi Cheng Jun Chen | 2015 | Nano Research2015，8，10： | 14 |
| 3 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 4 | Analysis of Wave Loads on A Semi-Submersible Platform显示文摘For the global and structural fatigue strength analysis of a semi-submersible platform, wave loads under design con-ditions are calculated by use of the three-dimensional boundary dement method. Methods for calculating the forward-speed free-surface Green function are discussed and a computer program with this Green function is developed. Accordingto the special rules, the wave loads under several typical design conditions of the platform are calculated. The maximumvertical bending moment, torsion moment and horizontal split force are determined from a series of contour maps of waveloads for the wave period of 5 to 18 seconds at a certain interval and the wave phase of O° to 360° at a certain interval.The wave height is determined by the function of wave period with a given exceedance probability. The maximum waveloads under the combination of wave parameters are used as the input of hydrodynamic pressure in the three-dimensionalfinite element analysis process. The transfer functions of wave loads on the platform are used for the fatigue strength anal-ysis of the K-tubular joint and the sub-model of the structure. | QIAN Kun(钱昆) WANG Yanying(王言英) | 2002 | China Ocean Engineering2002，17，3： | 12 |
| 5 | Risk Assessment of Heavy Metal Pollution in Sediments of the Fenghe River by the Fuzzy Synthetic Evaluation Model and Multivariate Statistical Methods显示文摘Concentrations of heavy metals in 74 sediment samples from the Fenghe River, which originates from the north of the Qinling Mountains and flows through Xi'an, Shaanxi Province, China, were characterized by employing geographic information system(GIS)mapping, fuzzy synthetic assessment, and multivariate statistical analysis to determine the enrichment characteristics of heavy metals as well as their potential risks of pollution to sediments. Al, Cd, and Co were the major pollutants, with a high enrichment factor(EF) value. Heavy metal concentrations from samples near the paper plant were maintained at a high level. Significant enrichment of Al, Ba, Cr, Ni, Pb, and Co was found in the midstream and downstream, while high concentration of Cu occurred in the headwater stream. Based on the cluster and principal component analyses, sediment metals mainly came from the paper plants, agronomic practices, natural sources, and tourism, with a contribution of 51.59%, 23.01%, 14.21%, and 9.88%, respectively. Sediment pollution assessment explored using fuzzy theory based on the entropy method and toxicity coefficient showed that 26, 32, and 11 sites fell into Class III(slightly polluted), Class IV(moderately polluted), and Class V(heavily polluted), respectively, and their scores of membership degree in the polluted level were on the rise, suggesting a relatively high degree of sediment metal pollution in the study area. Closely related to the excessive industrial and agricultural applications, metal pollution in sediment is necessary to be addressed in the Fenghe River. | YANG Yang ZHOU Zhengchao BAI Yanying CAI Yimin CHEN Weiping | 2016 | Pedosphere2016，26，3： | 12 |
| 6 | Variable frequency of pulse hydraulic fracturing for improving permeability in coal seam显示文摘Variable frequency,a new pattern of pulse hydraulic fracturing,is presented for improving permeability in coal seam.A variable frequency pulse hydraulic fracturing testing system was built,the mould with triaxial loading was developed.Based on the monitor methods of pressure sensor and acoustic emission,the trials of two patterns of pulse hydraulic fracturing of single frequency and variable frequency were carried out,and at last fracturing mechanism was analyzed.The results show that the effect of variable frequency on fracture extension is better than that of single frequency based on the analysis of macroscopic figures and AE.And the shortage of single frequency is somewhat remedied when the frequency is variable.Under variable frequency,the pressure process can be divided into three stages:low frequency band,pressure stability band and high frequency band,and rupture pressure of the sample is smaller than that of the condition of single frequency.Based on the Miner fatigue theory,the effect of different loading sequences on sample rupture is discussed and the results show that it is better to select the sequence of low frequency at first and then high frequency.Our achievements can give a basis for the improvement and optimization of the pulse hydraulic fracturing technology. | Li Quangui Lin Baiquan Zhai Cheng Ni Guanhua Peng Shen Sun Chen Cheng Yanying | 2013 | International Journal of Mining Science and Technology2013，23，6： | 12 |
| 7 | Sinomenine reduces iNOS expressionvia inhibiting the T-bet IFN-γ pathway in experimental autoimmune encephalomyelitis in rats显示文摘Sinomenine is a bioactive alkaloid isolated from the Chinese medicinal plant Sinomenium acutum.It is widely used as an immunosuppressive drug for treating rheumatic and arthritic diseases.In our previous studies,we found that sinomenine reduced cellular infiltration within the spinal cord and alleviated experimental autoimmune encephalomyelitis(EAE) in rats.In this study,we further investigated the mechanisms of sinomenine treatment in EAE rats.In EAE rats,treatment with sinomenine exerted an anti-inducible NO synthase(anti-iNOS) effect,which is related to the reductions of Th1 cytokine interferon-γ(IFN-γ) and its transcription factor,T-bet,in spinal cords.Moreover,sinomenine treatment of splenocytes stimulated with anti-CD3 antibody and recombinant rat interleukin 12 reduced the expression of T-bet and IFN-γ in vitro and also reduced the capability of supernatants of splenocyte culture to induce iNOS expression by primary astrocytes.However,sinomenine had no direct inhibitory effect on iNOS produced by astrocytes cultured with IFN-γ and tumor necrosis factor α in vitro.In conclusion,the anti-iNOS effect of sinomenine on EAE is mediated via the suppression of T-bet /IFN-γ pathway. | Bingjie Gu Yanying Zeng Cheng Yin Huijiuan Wang Xiaofan Yang Song Wang Xiaohui Ji | 2012 | The Journal of Biomedical Research2012，26，6： | 11 |
| 8 | Carbon materials from melamine sponges for supercapacitors and lithium battery electrode materials: A review显示文摘With the increasing energy demand together with the deteriorating environment and decreasing fossil fuel resources,the development of highly efficient energy conversion and storage devices is one of the key challenges of both fundamental and applied research in energy technology.Melamine sponges(MS)with low density,high nitrogen content,and high porosity have been used to design and obtain three‐dimensional porous carbon electrode materials.More importantly,they are inexpensive,environment‐friendly,and easy to synthesize.There have been many reports on the modification of carbonized MS and MS‐based composites for supercapacitor and lithium battery electrode materials.In this paper,recent studies on the fabrication of electrode materials using MS as raw materials have been mainly reviewed,including carbonation,doping activation,and composite modification of MS,and expectations for the development of porous carbon materials for energy storage as a reference with excellent performance,environment‐friendliness,and long life. | Yanying Shi Guijing Liu Rencheng Jin Hui Xu Qingyao Wang Shanmin Gao | 2019 | Carbon Energy2019，1，2： | 11 |
| 9 | Self-template synthesis of double-layered porous nanotubes with spatially separated photoredox surfaces for efficient photocatalytic hydrogen production显示文摘Improving charge carriers separation to achieve high photoconversion efficiency in heterogeneous photocatalysts is highly desirable.Herein,heterostructured ZnS@CdS double-layered porous nanotubes(PNTs),in which the spatially separated reduction and oxidation reaction sites lie on the outer and inner shell,respectively,are fabricated through a robust self-template conversion strategy.After selective photo-deposition of Ni and CoO_x as dual cocatalysts,Ni nanoparticles as electron collectors and reduction reaction sites are loaded on the outer shell,while CoO_x nanoparticles as hole collectors and oxidation reaction sites are loaded on the inner shells.As a result,a novel CoO_x/ZnS@CdS/Ni photocatalyst is obtained and shows high visible-light-driven photocatalytic hydrogen production activity owing to the synergistic effect of self-template-derived thin mesoporous heterojunctions and photo-depositionderived spatially separated dual cocatalysts,which can significantly provide driving force for the ordered transfer of photogenerated electrons and holes toward opposite direction and promote the surface catalytic reaction.Additionally,the facile strategy can be broadened to the preparation of CoO_x/ZnSe@CdSe/NiPNTs with enhanced photocatalytic activity. | Yani Xin Yi Huang Kui Lin Yifu Yu Bin Zhang | 2018 | Science Bulletin2018，63，10： | 9 |
| 10 | Robust self-supported anode by integrating Sb2S3 nanoparticles with S,N-codoped graphene to enhance K-storage performance显示文摘Developing high-performance anode materials for potassium-ion batteries is significantly urgent. We here demonstrate Sb_2S_3 nanoparticles(~20 nm) homogeneously dispersed in porous S,N-codoped graphene framework(Sb_2S_3-SNG) as a self-supported anode material for potassium-ion batteries. The rational structure design of integrating Sb_2S_3 nanoparticles with S,N-codoped graphene contributes to high reactivity, strong affinity, good electric conductivity, and robust stability of the composite, enabling superior K-storage performance. Moreover, the self-supported architecture significantly decreases the inactive weight of the battery, resulting in a high energy density of a Sb_2S_3-SNG/KVPO_4 F-C full cell to ~166.3 W h kg^(-1). | Yanying Lu Jun Chen | 2017 | Science China Chemistry2017，60，12： | 9 |
| 11 | Evaluation of water resources conserved by forests in the Hani rice terraces system of Honghe County,Yunnan,China:an application of the fuzzy comprehensive evaluation model显示文摘The Hani Rice Terraces System, based on gravity-flow irrigation, is one of the Globally Important Agricultural Heritage Systems(GIAHS) pilot sites selected by FAO in 2010. The water resource plays an important role in the sustainable development of this system. The value of water conserved by the forest is influenced by natural, economic and social factors. In this paper, the water quality, per capita water resources, per capita GDP and population density are chosen as indices to construct an index system for a comprehensive evaluation of water resources value. The weights of these indices are 0.443, 0.31, 0.141 and 0.106 respectively, which are determined by the analytic hierarchy process(AHP) method. The water resources value has been assessed by the fuzzy comprehensive evaluation model. The results show that the water resources value in the Hani Rice Terraces System is 4.25 RMB/m^3. Evaluating the value of water resources in the Hani Rice Terraces System can provide a reference for ecological compensation, for raising public awareness of the importance of protecting the system, and ultimately achieving its sustainable development. | LI Jing MIN Qingwen LI Wenhua BAI Yanying YANG Lun Dhruba Bijaya G C | 2016 | Journal of Mountain Science2016，13，4： | 8 |
| 12 | Natural hydroxyanthraquinoid pigments as potent food grade colorants:an overview显示文摘Natural pigments and colorants are widely used in the world in many industries such as textile dying,food processing or cosmetic manufacturing.Among the natural products of interest are various compounds belonging to carotenoids,anthocyanins,chlorophylls,melanins,betalains...The review emphasizes pigments with anthraquinoid skeleton and gives an overview on hydroxyanthraquinoids described in Nature,the first one ever published.Trends in consumption,production and regulation of natural food grade colorants are given,in the current global market.The second part focuses on the description of the chemical structures of the main anthraquinoid colouring compounds,their properties and their biosynthetic pathways.Main natural sources of such pigments are summarized,followed by discussion about toxicity and carcinogenicity observed in some cases.As a conclusion,current industrial applications of natural hydroxyanthraquinoids are described with two examples,carminic acid from an insect and Arpink red^(™)from a filamentous fungus. | Yanis CARO Linda ANAMALE Mireille FOUILLAUD Philippe LAURENT Thomas PETIT Laurent DUFOSSE | 2012 | Natural Products and Bioprospecting2012，2，5： | 8 |
| 13 | Fe3O4/Au composite nano-particles and their optical properties显示文摘Fe3O4/Au composite particles with core/shell structure were prepared by reduction of Au3+ with hydroxylamine in the presence of an excess of Fe3O4 as seeds.The resultant col-loids,with an average diameter of less than 100 nm,were obtained;the remaining non-reacted Fe3O4 seeds can be removed by treatment with diluted HCl solution.The Fe3O4/Au colloids ex-hibit a characteristic peak of UV-visible spectra,which largely depend on the size of the particle and the suspension medium.The localized surface plasmon resonance peaks red shift and broaden with increased nanoparticle diameter or increased solvent ionic strength.The optical property is very important in the establishment of means for the detection of biomolecules. | CUI Yali HUI Wenli SU Jing WANG Yani CHEN Chao | 2005 | Science China Chemistry2005，48，4： | 8 |
| 14 | Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells显示文摘Shenkang injection (SKI) is a classic prescription composed of Radix Astragali, rhubarb, Astragalus, Safflower, and Salvia. This treatment was approved by the State Food and Drug Administration of China in 1999 for treatment of chronic kidney diseases based on good efficacy and safety. This study aimed to investigate the protective effect of SKI against high glucose (HG)-induced renal tubular cell senescence and its underlying mechanism. Primary renal proximal tubule epithelial cells were cultured in (1) control medium (control group), medium containing 5 mmol/L glucose;(2) mannitol medium (mannitol group), medium containing 5 mmol/L glucose, and 25 mmol/L mannitol;(3) HG medium (HG group) containing 30 mmol/L glucose;(4) SKI treatment at high (200 mg/L), medium (100 mg/L), or low (50 mg/L) concentration in HG medium (HG+ SKI group);or (5) 200 mg/L SKI treatment in control medium (control+ SKI group) for 72 h. HG-induced senescent cells showed the emergence of senescence associated heterochromatin foci, up-regulation of P16INK4 and cyclin D1, increased senescence-associated β-galactosidase activity, and elevated expression of membrane decoy receptor 2. SKI treatment potently prevented these changes in a dose-independent manner. SKI treatment prevented HG-induced up-regulation of pro-senescence molecule mammalian target of rapamycin and p66Shc and down-regulation of anti-senescence molecules klotho, sirt1, and peroxisome proliferator-activated receptor-g in renal tubular epithelial cells. SKI may be a novel strategy for protecting against HG-induced renal tubular cell senescence in treatment of diabetic nephropathy. | Biqiong Fu Jie Yang Jia Chen Lirong Lin Kehong Chen Weiwei Zhang Jianguo Zhang Yani He | 2019 | Frontiers of Medicine2019，13，2： | 8 |
| 15 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 16 | Sirtuin 5:a review of structure,known inhibitors and clues for developing new inhibitors显示文摘Sirtuins(SIRTs) are nicotinamide adenine dinucleotide(NAD^+)-dependent protein deacetylases,which regulate important biological processes ranging from apoptosis,age-associated pathophysiologies,adipocyte and muscle differentiation,and energy expenditure to gluconeogenesis.Very recently,sirtuin 5(SIRT5) has received considerable attention due to that it was found to have weak deacetylase activity but strong desuccinylase,demalonylase and deglutarylase activities,and it was also found to be associated with several human diseases such as cancer,Alzheimer's disease,and Parkinson's disease.In this review,we for the first time summarized the structure characteristics,known peptide and small-molecule inhibitors of SIRT5,extracted some clues from current available information and introduced some feasible,practical in silico methods,which might be useful in further efforts to develop new SIRT5 inhibitors. | Lingling Yang Xiaobo Ma Yanying He Chen Yuan Quanlong Chen Guobo Li Xianggui Chen | 2017 | Science China(Life Sciences)2017，60，3： | 7 |
| 17 | Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy显示文摘Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE-1) are also overexpressing in the reticuloendothelial system(RES). Therefore,polyethylene glycol(PEG) modification of HA-based DDS is necessary to reduce RES capture.Unfortunately, pegylation remarkably inhibits tumor cellular uptake and endosomal escapement,significantly compromising the in vivo antitumor efficacy. Herein, we developed a Dox-loaded HA-based transformable supramolecular nanoplatform(Dox/HCVBP) to overcome this dilemma. Dox/HCVBP contains a tumor extracellular acidity-sensitive detachable PEG shell achieved by a benzoic imine linkage.The in vitro and in vivo investigations further demonstrated that Dox/HCVBP could be in a 'stealth' state at blood stream for a long circulation time due to the buried HA ligands and the minimized nonspecific interaction by PEG shell. However, it could transform into a 'recognition' state under the tumor acidic microenvironment for efficient tumor cellular uptake due to the direct exposure of active targeting ligand HA following PEG shell detachment. Such a transformative concept provides a promising strategy to resolve the dilemma of natural ligand-based DDS with conflicting two processes of tumor cellular uptake and in vivo nonspecific biodistribution. | Lu Zhong Lu Xu Yanying Liu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Yongjun Wang Jin Sun Zhonggui He | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 18 | Homogenized Daily Relative Humidity Series in China during 1960?2017显示文摘Surface relative humidity(RH)is a key element for weather and climate monitoring and research.However,RH is not as commonly applied in studying climate change,partly because the observation series of RH are prone to inhomogeneous biases due to non-climate changes in the observation system.A homogenized dataset of daily RH series from 746 stations in Chinese mainland for the period 1960–2017,ChinaRHv1.0,has been developed.Most(685 or 91.82%of the total)station time series were inhomogeneous with one or more break points.The major breakpoints occurred in the early 2000s for many stations,especially in the humid and semi-humid zones,due to the implementation of automated observation across the country.The inhomogeneous biases in the early manual records before this change are positive relative to the recent automatic records,for most of the biased station series.There are more break points detected by using the MASH(Multiple Analysis of Series for Homogenization)method,with biases mainly around?0.5%and 0.5%.These inhomogeneous biases are adjusted with reference to the most recent observations for each station.Based on the adjusted observations,the regional mean RH series of China shows little long-term trend during 1960–2017[0.006%(10 yr)^?1],contrasting with a false decreasing trend[?0.414%(10 yr)?1]in the raw data.It is notable that ERA5 reanalysis data match closely with the interannual variations of the raw RH series in China,including the jump in the early 2000s,raising a caveat for its application in studying climate change in the region. | Zhen LI Zhongwei YAN Yani ZHU Nicolas FREYCHET Simon TETT | 2020 | Advances in Atmospheric Sciences2020，37，4： | 7 |
| 19 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 20 | Establishment and application of drilling sealing model in the spherical grouting mode based on the loosing-circle theory显示文摘There are quite a few studies that have been done on borehole sealing theory both domestically and internationally.The existing researches usually consider drilling of the surroundings as a dense homogeneous elastic body which does not meet the characteristics of real drilling of the fractured body.Based on the loosing-circle theory and analyses of the surrounding rock stress field,cracks and seepage fields,combined with Newtonian fluid spherical grouting model,we deduced the dynamic relationship between the seepage coefficient and rock or grouting parameters of the drilling sealing fluid mode of spherical fissure grouting.In this experiment,mucus was injected in the simulated coal seam and the permeability coefficient of the sealing body was calculated by using the model.To verify the validity of the model,the calculated sealing body number was compared with the extreme negative pressure that the sealing body could withstand.The theoretical model revealed the drilling sealing fluid mechanism,provided a method for the quantitative calculation of the drilling sealing fluid effect by grouting mode and a reference for the subsequent research of sealing mechanism. | Hao Zhiyong Lin Baiquan Gao Yabin Cheng Yanying | 2012 | International Journal of Mining Science and Technology2012，22，6： | 6 |
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