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| 1 | Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes显示文摘Background:To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus(DCP)metrics in patients with diabetes mellitus(DM).Methods:563 eligible eyes(221 with no diabetic retinopathy[DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography-angiography(OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Tokyo,Japan).Strict criteria were applied to exclude from analysis those DCP images with artifacts and of poor quality,including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality score.A customized MATLAB program was then used to quantify DCP morphology from the artifact-free DCP images by calculating three metrics:foveal avascular zone(FAZ),vessel density(VD),and fractal dimension(FD).Results:166(29.5%)eyes were excluded after quality control,leaving in the analysis 397 eyes(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 subjects.In the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity(VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;p<0.001)and with older age(β=−0.142;p=0.004).Conclusions:Quantitative artifact-free DCP metrics are associated with VA,DR severity,AL,subfoveal choroidal thickness,age,and BMI in diabetic patients.The effects of ocular and systemic factors should be considered for meaningful interpretations of DCP changes in DM patients. | Fang Yao Tang Erica O.Chan Zihan Sun Raymond Wong Jerry Lok Simon Szeto Jason C.Chan Alexander Lam Clement C.Tham Danny S.Ng Carol Y.Cheung | 2020 | Eye and Vision2020，7，1： | 7 |
| 2 | 心脏节律蕴涵的确定性动力学机制重构显示文摘本研究以受迫非线性动力学系统为分析模型 ,以Volterra级数方法为基础 ,研究了心脏节律的确定性动力学机制重构问题。首先 ,采用最优变换方法充分表征相应级数项蕴涵的确定性动力学机制 ;其次 ,利用EM算法对观测和动力噪声强度、确定性动力学行为、模型结构和参数进行迭代采样 ,实现从多种生理过程的影响中准确重构心脏节律的确定性动力学机制。应用实验数据表明 :重构模型具有与心脏节律非常相似的动力学行为和统计特性 ;心脏节律内在机制具有初始值敏感性质。 | 裴文江 何振亚 杨绿溪 Stephen S.Hull John Y.Cheung | 2005 | 中国生物医学工程学报2005，24，2： | 1 |
| 3 | Presurgical intravenous parecoxib sodium and follow‐up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid‐related adverse effects显示文摘 | T. J.Gan G. P.Joshi S. Z.Zhao D. B.Hanna R. Y.Cheung C.Chen | 2004 | Acta Anaesthesiologica Scandinavica2004，，9： | 1 |
| 4 | Epidemiology of venous thromboembolism in a Chinese population显示文摘 | B. L. Y.Cheuk G. C. Y.Cheung S. W. K.Cheng | 2004 | Br J Surg2004，，4： | 1 |
| 5 | Leveraging the power of pooled data for cancer outcomes research显示文摘Background:Clinical trials continue to be the gold standard for determining the efficacy of novel cancer treatments,but they may also expose participants to the potential risks of unpredictable or severe toxicities.The development of validated tools that better inform patients of the benefits and risks associated with clinical trial participation can facilitate the informed consent process.The design and validation of such instruments are strengthened when we leverage the power of pooled data analysis for cancer outcomes research.Main body:In a recent study published in the Journal of Clinical Oncology entitled 'Determinants of early mortality among 37,568 patients with colon cancer who participated in 25 clinical trials from the adjuvant colon cancer endpoints database,' using a large pooled analysis of over 30,000 study participants who were enrolled in clinical trials of adjuvant therapy for early-stage colon cancer,we developed and validated a nomogram depicting the predictors of early cancer mortality.This database of pooled individual-level data allowed for a comprehensive analysis of poor prognostic factors associated with early death;furthermore,it enabled the creation of a nomogram that was able to reliably capture and quantify the benefit-to-risk profile for patients who are considering clinical trial participation.This toolcan facilitate treatment decision-making discussions.Conclusion:As China and other Asian countries continue to conduct oncology clinical trials,efforts to collate patient-level information from these studies into a large data repository should be strongly considered since pooled data can increase future capacity for cancer outcomes research,which,in turn,can enhance patient-physician discussions and optimize clinical care. | Kiara Hugh-Yeun Winson Y.Cheung | 2016 | Chinese Journal of Cancer2016，35，8： | 0 |
| 6 | LLG2/3作为复合体的共受体参与调控花粉管破裂显示文摘文章简介在被子植物的有性生殖过程中,花粉管是精细胞的运输载体,它经历与雌方多种组织和细胞的相互作用,最终将精细胞送至雌配子体进行双受精。为了鉴定参与花粉管细胞完整性调控的其他因子,课题组在系统地分析了拟南芥中的GPI-AP基因之后,发现了两个与LRE/LLG1相似、相互之间序列又非常相似的GPI-AP基因LLG2和LLG3,这两个基因在花粉中大量表达。 | Zengxiang Ge Yuling Zhao Ming-Che Liu Liang-Zi Zhou Lele Wang Sheng Zhong Saiying Hou Jiahao Jiang Tianxu Liu Qingpei Huang Junyu Xiao Hongya Gu Hen-Ming Wu Juan Dong Thomas Dresselhaus Alice Y.Cheung 瞿礼嘉 | 2020 | 科学新闻2020，，2： | 0 |
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