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| 1 | Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components显示文摘Dear Editor,With an estimated 240 million chronically infected people worldwide,hepatitis B virus(HBV)infection is a major public health problem(Schweitzer et al.,2015).Despite more than 30 years of in tense research,many aspects of the HBV life cycle still remain unknown. | Yong Lin Chunchen Wu Xueyu Wang Thekla Kemper Anthony Squire Matthias Gunzer Jiming Zhang Xinwen Chen Mengji Lu | 2019 | Protein & Cell2019，10，1： | 5 |
| 2 | The Evaporation Effect on the Isotopes in the Yellow River Water显示文摘Based on the isotope analysis result of water samples in the 18 sections of the Yellow River, the variation of δ 18 O and δD have been analyzed. From near the source to the entrance to the sea, the Yellow River has a general trend that the ratios of the stable isotope increase progressively; The main factors affecting the isotopes in the river water are mixing of external water bodies,evaporation and others; In the river segment between Lanzhou and Baotou and in lower reaches, the extent of the evaporation effect on the isotope fractionation from the river water surface is limited but the evaporation from the irrigated river water and the return flow is one of the main factors affecting the isotopes in river water. | SU Xiaosi, LIN Xueyu and LIAO Zisheng (College of Environment and Resources, Jilin University, Changchun 130026, P.R.China) WANG Jinsheng (Beijing Normal University, Beijing, 100873, P. R. China) | 2001 | Global Geology2001，6，2： | 1 |
| 3 | Performance and Mechanisms of Fluoride Removal from Groundwater by Lanthanum-aluminum-loaded Hydrothermal Palygorskite Composite显示文摘 | ZHANG Shengyu | 2015 | Chemical Research in Chinese Universities2015，31，1： | 1 |
| 4 | The maim Factor Affecting Isotopes of Yellow River Water in China显示文摘 | Xiaosi Su Xueyu Lin Zisheng Liao | 2004 | Water International2004，，： | 1 |
| 5 | Transport and fate modeling of nitrobenzene in groundwater after the Songhua River pollution accident 显示文摘 | ZHANG Wenjing LIN Xueyu SU Xiaosi | 2010 | Journal of Environmental Management2010，91，11： | 1 |
| 6 | Removal of Fluoride from Groundwater by Adsorption onto La( Ⅲ)-Al(Ⅲ ) Loaded Scoria Adsorbent 显示文摘 | ZHANG Shengyu LU Ying LIN Xueyu | 2014 | Applied Surface Science2014，303，： | 1 |
| 7 | Genome resequencing reveals the evolutionary history of garlic reproduction traits显示文摘The propagation of cultivated garlic relies on vegetative cloves,thus flowers become non-essential for reproduction in this species,driving the evolution of reproductive feature-derived traits.To obtain insights into the evolutionary alteration of reproductive traits in the clonally propagated garlic,the evolutionary histories of two main reproduction-related traits,bolting and flower differentiation,were explored by genome analyses using 134 accessions displaying wide diversity in these two traits.Resequencing identified 272.8 million variations in the garlic genome,198.0million of which represent novel variants.Population analysis identified five garlic groups that have evolved into two clades.Gene expression,single-cell transcriptome sequencing,and genome-wide trait association analyses have identified numerous candidates that correlate with reproductive transition and flower development,some of which display distinct selection signatures.Selective forces acting on the B-box zinc finger protein-encoding Asa2G00291.1,the global transcription factor group E protein-encoding Asa5G01527.1,and VERNALIZATION INSENSITIVE 3-like Asa3G03399.1 appear to be representative of the evolution of garlic bolting.Plenty of novel genomic variations and trait-related candidates represent valuable resources for biological studies of garlic.Numerous selective signatures from genes associated with the two chosen reproductive traits provide important insights into the evolutionary history of reproduction in this clonally propagated crop. | Haiping Wang Einat Shemesh-Mayer Jiangjiang Zhang Song Gao Zheng Zeng Zemao Yang Xueyu Zhang Huixia Jia Yanzhou Wang Jiangping Song Xiaohui Zhang Wenlong Yang Qiaoyun He Amir Sherman Lin Li Rina Kamenetsky Touming Liu | 2023 | Horticulture Research2023，10，11： | 0 |
| 8 | Manipulating oxygenate adsorption on N-doped carbon by coupling with CoSn alloy for bifunctional oxygen electrocatalyst显示文摘Highly active bifunctional oxygen electrocatalysts accelerate the development of high-performance Zn-air battery,but suffer from the mismatched activities of oxygen evolution reaction(OER)and oxygen reduced reaction(ORR).Herein,highly integrated bifunctional oxygen electrocatalysts,cobalt-tin alloys coated by nitrogen doped carbon(CoSn@NC)are prepared by MOFs-derived method.In this hybrid catalyst,the binary CoSn nanoalloys mainly contribute to highly active OER process while the Co(or Sn)-N-C serves as ORR active sites.Rational interaction between CoSn and NC donates more rapid reaction kinetics than Pt/C(ORR)and IrO_(2)(OER).Such CoSn@NC holds a promise as air-cathode electrocatalyst in Zn-air battery,superior to Pt/C+IrO_(2)catalyst.First-principles calculations predict that CoSn alloys can upgrade charge redistribution on NC and promote the transfer to reactants,thus optimizing the adsorption strength of oxygen-containing intermediates to boost the overall reactivity.The tuning of oxygenate adsorption by interactions between alloy and heteroatom-doped carbon can guide the design of bifunctional oxygen electrocatalysts. | Chenlong Dong Xilin Zhang Shaoning Zhang Siwei Zhao Xueyu Lin Xin Wang Yajing Zhang Fuqiang Huang | 2023 | Green Energy & Environment2023，8，5： | 0 |
| 9 | Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3显示文摘The TEA domain(TEAD)family proteins(TEAD1-4)are essential transcription factors that control cell differentiation and organ size in the Hippo pathway.Although the sequences and structures of TEAD family proteins are highly conserved,each TEAD isoform has unique physiological and pathological functions.Therefore,the development and discovery of subtype selective inhibitors for TEAD protein will provide important chemical probes for the TEAD-related function studies in development and diseases.Here,we identified a novel TEAD 1/3 covalent inhibitor(DC-TEADin1072)with biochemical IC50 values of 0.61±0.02 and 0.58±0.12μmol/L against TEAD1 and TEAD3,respectively.Further chemical optimization based on DC-TEAD in 1072 yielded a selective TEAD3 inhibitor DCTEAD3 in03 with the IC_(50) value of 0.16±0.03μmol/L,which shows 100-fold selectivity over other TEAD isoforms in activity-based protein profiling(ABPP)assays.In cells,DC-TEAD3 in03 showed selective inhibitory effect on TEAD3 in GAL4-TEAD(1-4)reporter assays with the IC50 value of1.15μmol/L.When administered to zebrafish juveniles,experiments showed that DC-TEAD3 in03 reduced the growth rate of zebrafish caudal fins,indicating the importance of TEAD3 activity in controlling proportional growth of vertebrate appendages. | Tian Lu Yong Li Wenchao Lu TWGM Spitters Xueyu Fang Jun Wang Simian Cai Jing Gao Yanting Zhou Zhe Duan Huan Xiong Liping Liu Qi Li Hualiang Jiang Kaixian Chen Hu Zhou Hua Lin Huijin Feng Bing Zhou Christopher L.Antos Cheng Luo | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 0 |
| 10 | A small but important step to enhance groundwater research in China显示文摘Sponsored by the Chinese Academy of Sciences (CAS) and the National Natural Science Foundation of China, Chinese Science Bulletin (CSB) is one of the well-known comprehensive academic journals of wide impacts in the field of natural sciences in China. Groundwater | Lin Xueyu | 2013 | Chinese Science Bulletin2013，58，25： | 0 |
| 11 | Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms显示文摘Methicillin-resistant Staphylococcus aureus (MRSA), the most common pathogen in hospital and community environments, can cause serious and even fatal infections. The antibiotics currently used for clinical treatment of MRSA have developed resistance, and there is an urgent need to develop new antimicrobials to treat infections caused by MRSA strains. Quinoline analogues play an important role in the development of antimicrobials. Herein, we discussed the current development of antibacterial activities of quinoline analogues, mainly for anti-MRSA activity, and their structure-activity relationships (SARs) from the perspective of using the quinoline nucleus to search for novel potential anti-MRSA candidates. Additionally, the mechanisms of some representative quinoline analogues against MRSA were clarified. Altogether, this review could provide further insights for the rational development of quinoline-based antibacterial drugs, especially against MRSA. | Hong Yao Liping Cui Hang Liu Xueyu Li Lin Shen Ruige Yang Shangshang Qin Yong Guo | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
| 12 | Applicability and Limits of Bioremediation of Contaminated Groundwater by Organic Compounds显示文摘This paper gives in some ways a broad look at the Biorcmediation Technology in the treatment of polluted groundwater. Environmentalists and Hydrologeologists around the world, especially in the developed countries welcomed this revolutionizing technique at a moment when other methods were beconling rather expensive and sources of secondary and more challenging pollution problems across sole fresh groundwater. Bioremediation of contaminated groundwater is based on the use of bacteria which breakdown organic matters to more stable forms, which will not create nuisance or give off foul odors. The Applicability of this technology at a specific site lies in the understanding of the site’s hydrogeologic, physio- chemical backgrounds and the knowledge of the properties of the designated bacteria colonies, which would likely stabilize the contaminants. These are key points, which determine the success of the all process. Only, by complying with all those mea- surcs, Biorcmediation can meet all the expectations. | Taboure Aboubacar and Lin Xueyu (Jilin university. Changchun, 130026 P. R. China) | 2001 | Global Geology2001，6，1： | 0 |
| 13 | Metabolic utilization of intravenously injected iron from different iron sources in target tissues of broiler chickens显示文摘No information is available regarding the utilization of iron (Fe) from different Fe sources at a targettissue level. To detect differences in Fe metabolic utilization among Fe sources, the effect of intravenouslyinjected Fe on growth performance, hematological indices, tissue Fe concentrations and Fe-containingenzyme activities and gene expressions of Fe-containing enzymes or protein in broilers was investigated.On d 22 post-hatching, a total of 432 male chickens were randomly allotted to 1 of 9 treatments ina completely randomized design. Chickens were injected with either a 0.9% (wt/vol) NaCl solution(control) or a 0.9% NaCl solution supplemented with Fe sulphate or 1 of 3 organic Fe sources. The 3organic Fe sources were Fe chelates with weak (Fe-MetW), moderate (Fe-ProtM) or extremely strong (Fe-ProtES) chelation strength. The 2 Fe dosages were calculated according to the Fe absorbabilities of 10%and 20% every 2 d for a duration of 20 d. Iron injection did not affect (P > 0.05) ADFI, ADG or FCR duringeither 1 to 10 d or 11 to 20 d after injections. Hematocrit and Fe concentrations in the liver and kidney ond 10 after Fe injections, and Fe concentrations in the liver or pancreas and ferritin heavy-chain (FTH1)protein expression level in the liver or spleen on d 20 after Fe injections increased (P≤0.05) as injectedFe dosages increased. When the injected Fe level was high at 20% Fe absorbability, the chickens injectedwith Fe-ProtES had lower (P < 0.001) liver or kidney Fe concentrations and spleen FTH1 protein levelsthan those injected with Fe-MetW or Fe-ProtM on d 20 after injections. And they had lower (P < 0.05)liver cytochrome C oxidase mRNA levels on d 20 after injections than those injected with Fe-MetW or Fesulphate. The results from this study indicate that intravenously injected Fe from Fe-ProtES was the least utilizable and functioned in the sensitive target tissue less effectively than Fe from Fe sulfate, Fe-MetW or Fe-ProtM. | Lin Lu Xueyu Dong Xuelian Ma Liyang Zhang Sufen Li Xugang Luo Xiudong Liao | 2022 | Animal Nutrition2022，，2： | 0 |
| 14 | Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release显示文摘Hepatitis B virus(HBV)produces and releases various particle types,including complete virions,subviral particles with envelope proteins,and naked capsids.Recent studies demonstrate that HBV exploits distinct intracellular membrane trafficking pathways,including the endosomal vesicle trafficking and autophagy pathway,to assemble and release viral and subviral particles.Herein,we summarize the findings about the distinct roles of autophagy and endosomal membrane trafficking and the interaction of both pathways in HBV replication,assembly,and release. | Jia Li Yong Lin Xueyu Wang Mengji Lu | 2024 | Virologica Sinica2024，39，1： | 0 |
| 15 | Identification of a Novel OsCYP2 Allele that Was Involved in Rice Response to Low Temperature Stress显示文摘Cyclophilin(CYP)plays an important role in plant response to stress,and OsCYP2,one gene of cyclophlilin family,is involved in auxin signal transduction and stress signaling in rice.However,the mechanism that OsCYP2 is involved in rice response to low temperature is still unclear.We identified a new OsCYP2 allelic mutant,lrl3,with fewer lateral roots,and the differences in shoot height,primary root length and adventitious root length increased with the growth process compared to the wild-type plant.Auxin signaling pathway was also affected and became insensitive to gravity.The transgenic rice plants with over-expression of OsCYP2 were more tolerant to low temperature than the wild-type plants,suggesting that OsCYP2 was involved in the low temperature response in rice.In addition,OsCYP2 negatively regulated the expression of OsTPS38,a terpene synthase gene,and was dependent on the OsCDPK7-mediated pathway in response to low temperature stress.OsTPS38-overexpressed transgenic line ox-2 was more sensitive to low temperature.Therefore,OsCYP2 may negatively regulate OsTPS38 through an OsCDPK7-dependent pathway to mediate the response to low temperature in rice.These results provide a new basis for auxin signaling genes to regulate rice response to low temperature stress. | Hongxiu Gao Lin Zhu Tianqi Liu Xueyu Leng Zhenxing Zhu Wei Xie Haitao Lv Zhengxun Jin Ping Wu Zhongchen Zhang | 2023 | Phyton-International Journal of Experimental Botany2023，92，6： | 0 |
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