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| 1 | Bushen Qiangjin capsule(补肾强筋胶囊) inhibits the Wnt/β-catenin pathway to ameliorate papain-induced knee osteoarthritis in rats显示文摘OBJECTIVE:To evaluate the molecular mechanism underlying the beneficial effect of Bushen Qiangjin capsule(补肾强筋胶囊,BSQJ),a Traditional Chinese Medicine,on knee osteoarthritis(KOA).METHODS:In the present study,32 female Sprague-Dawley rats were randomly divided into four groups:control,KOA,high-dose BSQJ(H-BSQJ),and low-dose BSQJ(L-BSQJ).After successfully establishing the KOA model by intra-articular injection of papain,H-BSQJ and L-BSQJ groups were intragastrically administered 0.243 and 0.122 g/kg BSQJ,respectively,daily for 6 weeks.At the end of the experiment,knee articular cartilage tissues of rats were collected for evaluation by hematoxylin and eosin staining,Safranin O-Fast Green staining,and terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay.Serum interleukin-1βand tumor necrosis factor-αlevels of rats were detected with an enzyme-linked immunosorbent assay method.Gene expression of Wnt-4,β-catenin,Frizzled-2,glycogen synthase kinase-3β(GSK-3β),cysteinyl aspartate-specific proteinases 3 and 9(caspases 3 and 9),collagen typeⅡalpha 1(Col2 a1),and matrix metalloproteinases 1 and 13(MMP-1 and MMP-3)of rat knee articular cartilage was quantified by reverse transcription-quantitative polymerase chain reaction analysis.Wnt-4,β-catenin,Frizzled-2,GSK-3β,cleaved caspase-3,and cleaved caspase-9 protein expression in rat knee articular cartilage was determined by western blot analysis.RESULTS:BSQJ obviously reduced pathological damage and matrix degradation of articular cartilage in KOA rats.Compared with the KOA group,H-BSQJ rats exhibited downregulated m RNA and protein expression of Wnt-4,β-catenin,Frizzled-2,and caspase-3,as well as upregulated m RNA and protein expression of GSK-3β.In addition,H-BSQJ significantly increased m RNA expression of Col2 a1 and decreased m RNA expression of MMP-1 and MMP-13.CONCLUSION:BSQJ exerted a beneficial effect on KOA by a mechanism involving downregulation of the Wnt/β-catenin pathway,which inhibited both cartilage extracellular matrix degradation and chondrocyte apoptosis to ameliorate KOA in rats. | YAO Nan CHEN Guocai LU Yanyan XU Xuemeng ZHAO Chuanxi HUANG Xuejun LIU Wengang PENG Sha WU Huai | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 5 |
| 2 | Bottom-up holistic carrier management strategy induced synergistically by multiple chemical bonds to minimize energy losses for efficient and stable perovskite solar cells显示文摘The defects from electron transport layer,perovskite layer and their interface would result in carrier nonradiative recombination losses.Poor buried interfacial contact is detrimental to charge extraction and device stability.Here,we report a bottom-up holistic carrier management strategy induced synergistically by multiple chemical bonds to minimize bulk and interfacial energy losses for high-performance perovskite photovoltaics.4-trifluoromethyl-benzamidine hydrochloride(TBHCl)containing–CF_(3),amidine cation and Cl^(-)is in advance incorporated into SnO_(2)colloid solution to realize bottom-up modification.The synergistic effect of multiple functional groups and multiple-bond-induced chemical interaction are revealed theoretically and experimentally.F and Cl^(-)can passivate oxygen vacancy and/or undercoordinated Sn^(4+)defects by coordinating with Sn^(4+).The F can suppress cation migration and modulate crystallization via hydrogen bond with FA^(+),and can passivate lead defects by coordinating with Pb^(2+).The–NH_(2)–C=NH^(+)_(2)and Cl^(-)can passivate cation and anion vacancy defects through ionic bonds with perovskites,respectively.Through TBHCl modification,the suppression of agglomeration of SnO_(2)nanoparticles,bulk and interfacial defect passivation,and release of tensile strains of perovskite films are demonstrated,which resulted in a PCE enhancement from 21.28%to 23.40%and improved stability.With post-treatment,the efficiency is further improved to 23.63%. | Baibai Liu Ru Li Qixin Zhuang Xuemeng Yu Shaokuan Gong Dongmei He Qian Zhou Hua Yang Xihan Chen Shirong Lu Zong-Xiang Xu Zhigang Zang Jiangzhao Chen | 2023 | Journal of Energy Chemistry2023，，1： | 1 |
| 3 | Aφ6-m Tunnel Boring Machine Steel Arch Splicing Manipulator显示文摘Robotic splicing of steel arches is a challenging task that is necessary to realize the grasping and docking of steel arches in a limited space.Steel arches often have a mass of more than 200 kg and length of more than 4 m.Owing to the large volume and mass of steel arches and the high requirements for accurately positioning the splicing,it is difficult for a general manipulator to meet the stiffness requirements.To enhance the structural stiffness of the steel arch splicing manipulator,a single-degree-of-freedom(DOF)closed-loop mechanism was added to the grasping structure of the manipulator.Based on the basic principle of structural synthesis,a solution model of the single-DOF closed-loop mechanism was developed,and alternative kinematic pairs of the mechanism with different input constraints and output requirements were derived.Based on this model,a design method for a single-DOF closed-loop grasping mechanism and a posture adjustment mechanism for a steel arch was devised.Combined with the same dimensional subspace equivalence principle of the graphical-type synthesis method,12 types of steel arch splicing manipulator were constructed.By analyzing the motion/force transmission and structural complexity of the steel arch splicing manipulators,the best scheme was selected.A prototype of the steel arch splicing manipulator was manufactured.Adams software was used to obtain clearly the output trajectory of the end of the manipulator.The relative spatial positions of the upper and lower jaws under different working stages were analyzed,demonstrating that the manipulator satisfied the grasping requirements.Through a steel arch splicing experiment,the grasping effect,docking accuracy,and splicing efficiency of the manipulator met the design requirements.The steel arch splicing manipulator can replace the manual completion of the steel arch splicing operation,significantly improving the operation efficiency. | Yuanfu He Yimin Xia Zhen Xu Jie Yao Bo Ning Xuemeng Xiao | 2022 | Chinese Journal of Mechanical Engineering2022，35，2： | 0 |
| 4 | Cellularmetabolism: A key player in cancer ferroptosis显示文摘Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular functions.Cellular metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell death.Ferroptosis is a recently discovered form of iron-dependent programmed cell death.The inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor progression.However,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well understood.Here,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this process.Additionally,we provided a detailed overview of agents used to induce cancer ferroptosis.We explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell killing.The combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments. | Xianjie Jiang Qiu Peng Mingjing Peng Linda Oyang Honghan Wang Qiang Liu Xuemeng Xu Nayiyuan Wu Shiming Tan Wenjuan Yang Yaqian Han Jinguan Lin Longzheng Xia Yanyan Tang Xia Luo Jie Dai Yujuan Zhou Qianjin Liao | 2024 | Cancer Communications2024，44，2： | 0 |
| 5 | Unraveling abnormal buried interface anion defect passivation mechanisms depending on cation-induced steric hindrance for efficient and stable perovskite solar cells显示文摘Although ionic liquids(ILs)have been widely employed to heal the defects in perovskite solar cells(PSCs),the corresponding defect passivation mechanisms are not thoroughly understood up to now.Herein,we first reveal an abnormal buried interface anion defect passivation mechanism depending on cationinduced steric hindrance.The IL molecules containing the same anion([BF4]^(-))and different sizes of imidazolium cations induced by substituent size are used to manipulate buried interface.It was revealed what passivated interfacial defects is mainly anions instead of cations.Theoretical and experimental results demonstrate that the large-sized cations can weaken the ionic bond strength between anions and cations,and facilitate the interaction between anions and SnO2as well as perovskites,which is conducive to interfacial defect passivation and ameliorating interfacial contact.It can be concluded that interfacial chemical interaction strength and defect passivation effect are positively correlated with the size of cations.The discovery breaks conventional thinking that large-sized modification molecules would weaken their chemical interaction with perovskite.Compared with the control device(21.54%),the device based on 1,3-Bis(1-adamantyl)-imidazolium tetrafluoroborate(BAIMBF4)with maximum size cations achieves a significantly enhanced efficiency of 23.61%along with much increased moisture,thermal and light stabilities. | Dongmei He Ru Li Baibai Liu Qian Zhou Hua Yang Xuemeng Yu Shaokuan Gong Xihan Chen Baomin Xu Shangfeng Yang Jiangzhao Chen | 2023 | Journal of Energy Chemistry2023，，5： | 0 |
| 6 | Vision Enhanced Generative Pre-trained Language Model for Multimodal Sentence Summarization显示文摘Multimodal sentence summarization(MMSS)is a new yet challenging task that aims to generate a concise summary of a long sentence and its corresponding image.Although existing methods have gained promising success in MMSS,they overlook the powerful generation ability of generative pre-trained language models(GPLMs),which have shown to be effective in many text generation tasks.To fill this research gap,we propose to using GPLMs to promote the performance of MMSS.Notably,adopting GPLMs to solve MMSS inevitably faces two challenges:1)What fusion strategy should we use to inject visual information into GPLMs properly?2)How to keep the GPLM′s generation ability intact to the utmost extent when the visual feature is injected into the GPLM.To address these two challenges,we propose a vision enhanced generative pre-trained language model for MMSS,dubbed as Vision-GPLM.In Vision-GPLM,we obtain features of visual and textual modalities with two separate encoders and utilize a text decoder to produce a summary.In particular,we utilize multi-head attention to fuse the features extracted from visual and textual modalities to inject the visual feature into the GPLM.Meanwhile,we train Vision-GPLM in two stages:the vision-oriented pre-training stage and fine-tuning stage.In the vision-oriented pre-training stage,we particularly train the visual encoder by the masked language model task while the other components are frozen,aiming to obtain homogeneous representations of text and image.In the fine-tuning stage,we train all the components of Vision-GPLM by the MMSS task.Extensive experiments on a public MMSS dataset verify the superiority of our model over existing baselines. | Liqiang Jing Yiren Li Junhao Xu Yongcan Yu Pei Shen Xuemeng Song | 2023 | Machine Intelligence Research2023，20，2： | 0 |
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