2篇
您的检索式：作者名="Xuanlin Huang"
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| 1 | PTBP1 promotes IRES-mediated translation of cyclin B1 in cancer显示文摘Cyclin B1 is an essential cyclin-dependent protein that involves in the G2/M transition.Multiple studies report that cyclin B1 is upregulated in cancers and promotes cancer progression.However,the mechanism of cyclin B1 upregulation remains unclear.Here we report that the 5′UTR of cyclin B1 mRNA contains an internal ribosome entry site(IRES)by using a bicistronic fluorescent reporter.We show that IRES can initiate the translation of cyclin B1,and the IRES-mediated translation is further activated under cell stress.Interacting trans-acting factors(ITAFs)are required by most IRES to initiate the translation.We find that PTBP1 promotes the IRES-mediated translation of cyclin B1 by binding to the 5′UTR of cyclin B1.On top of that,PTBP1 promotes the malignancy of ESCC cells.Our data suggest that the IRES-mediated translation of cyclin B1 plays an essential role in the cyclin B1 upregulation in cancers. | Xinyi Fan Zitong Zhao Liying Ma Xuanlin Huang Qimin Zhan Yongmei Song | 2022 | Acta Biochimica et Biophysica Sinica2022，54，5： | 1 |
| 2 | Flash Flood Disaster Assessment in Yuzhou District显示文摘Based on the basic maps,attribute data of watershed and outcomes of flash flood disaster investigation,this paper presents the techniques and achievements for flash flood disaster assessment in Yuzhou district. The primary preparedness for assessment was firstly introduced.Then,it was demonstrated that the main works of assessment,including design flood by rainfall-runoff modeling in watersheds,existing flood control capacity estimation,critical rainfall and stages determination,and flood dangerous zoning for the riverside villages in mountain-hill-area in Yuzhou district. Finally,some suggestions were provided to support flash flood management in Yuzhou district,including mining information from outcomes of flash flood disaster investigation and assessment,improving the monitoring and early warning system on flash flood,and identifying potential flash flood types and areas. | Li Changzhi Zhang Miao Zhang Qiyi Weng Jiachao Huang Xuanlin | 2017 | Meteorological and Environmental Research2017，8，3： | 0 |
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