3篇
您的检索式：作者名="Xiefeng Wang"
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| 1 | Brain Network Analysis of Schizophrenia Based on the Functional Connectivity显示文摘Network analysis based on graph theory has greatly promoted the cognition of the human brain network. A detailed brain network function connection analysis was carried out for the brain of normal human brain and mental illness patients. We studied the Magnetoencephalography(MEG) of 9 normal subjects and9 schizophrenics in left hemisphere temporal lobe and frontal lobe regions. And obtained the dynamic function connectivity matrix by calculating Pearson correlation coefficients that based on sliding time window and shorttime Fourier transform, and constructed weight and binary network by graph theory. Analyzed the small world properties of normal human brain networks, and compared the differences of network between normal subjects and patients with schizophrenia. | ZHANG Xuejun WANG Longqiang DING Yuhan HUANG Liya CHENG Xiefeng | 2019 | Chinese Journal of Electronics2019，28，3： | 3 |
| 2 | CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy显示文摘CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with leukoencephalopathy.However,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/NUTM2B-AS1.Here,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal myopathy.The CGG repeat expansions range from 161 to 669 repeat units.Most of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle weakness.Only one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance imaging.Muscle biopsies from three patients show a myopathic pattern and rimmed vacuoles.Analyses of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to pathogenesis.Our study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers. | Yan Shi Chunyan Cao Yiheng Zeng Yuanliang Ding Long Chen Fuze Zheng Xuejiao Chen Fanggui Zhou Xiefeng Yang Jinjing Li Liuqing Xu Guorong Xu Minting Lin Hiroyuki Ishiura Shoji Tsuji Ning Wang Zhiqiang Wang Wan-Jin Chen Kang Yang | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
| 3 | HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas显示文摘Ionizing radiation is a popular and effective treatment option for glioblastoma(GBM).However,resistance to radiation therapy inevitably occurs during treatment.It is urgent to investigate the mechanisms of radioresistance in GBM and to find ways to improve radiosensitivity.Here,we found that heat shock protein 90 beta family member 1(HSP90B1)was significantly upregulated in radioresistant GBM cell lines.More importantly,HSP90B1 promoted the localization of glucose transporter type 1,a key rate-limiting factor of glycolysis,on the plasma membrane,which in turn enhanced glycolytic activity and subsequently tumor growth and radioresistance of GBM cells.These findings imply that targeting HSP90B1 may effectively improve the efficacy of radiotherapy for GBM patients,a potential new approach to the treatment of glioblastoma. | Yanhui Li Yuqian Ge Mengjie Zhao Fangshu Ding Xiuxing Wang Zhumei Shi Xin Ge Xiefeng Wang Xu Qian | 2023 | The Journal of Biomedical Research2023，37，5： | 0 |
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