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| 1 | 北京友谊医院1998~2001年轮状病毒哨点监测分析显示文摘目的 了解 5岁以下儿童中以医院为基础的轮状病毒流行情况。方法 按WHO轮状病毒监测的通用方法 (CID 98)进行 ,轮状病毒检测采用聚丙烯酰胺凝胶电泳 /酶联免疫吸附试验(ELISA)。毒株分型用ELISA/逆转录聚合酶链反应。结果 从 1998年 4月至 2 0 0 1年 3月收集的4 84份腹泻患儿粪便标本中 ,检出阳性标本 12 3份 ,总的轮状病毒感染检出率为 2 5 .4 % ,住院和门诊患儿检出率分别是 31.6 %和 2 7.3% ,而在轮状病毒流行季节 ,则可以引起高达 4 6 .2 %急性腹泻住院率。腹泻患儿发病呈现两个明显的季节高峰 :一个由细菌性痢疾引起的夏季 (6~ 9月 )发病高峰 ,另一个是轮状病毒感染腹泻造成的秋冬季 (10~ 12月 )发病高峰。轮状病毒感染 96 .8%发生于 3岁以下幼儿 ,主要在 6~ 11月龄 (38.2 % )和 1~ 2岁 (2 8.5 % )年龄组 ,轮状病毒感染率在 6~ 35月龄年龄段最高。流行的轮状病毒G血清型依次为G1(5 5 .3% )、G2 (2 6 .8% )、G3(9.8% )和G4 (0 .8% ) ,没有发现G9型 ,10份 (8.1% )标本未能分型 ,混合感染 (0 .8% )罕见。结论 轮状病毒腹泻是北京市儿童的重要传染病 ,开发应用安全有效的轮状病毒疫苗将对减轻轮状病毒疾病负担有重要作用。 | 童志礼 马莉 章菁 侯安存 郑丽舒 金宗平 谢华萍 马兰 张丽杰 Ivanoff B Glass RI Bresee JS JIANG Xi Kilgore PE 方肇寅 | 2003 | 中华流行病学杂志2003，24，12： | 27 |
| 2 | 长春市儿童医院1998~2001年轮状病毒哨点监测分析显示文摘目的 为在中国开发和应用轮状病毒疫苗提供流行病学背景资料。方法 以医院为基础的哨点监测 ,在长春市儿童医院 5岁以下腹泻患儿中进行 ,收集患儿临床资料和粪便标本 ,轮状病毒检测用聚丙烯酰胺凝胶电泳 (PAGE)和 或酶联免疫吸附试验 (ELISA) ,毒株分型用ELISA和 或逆转录 聚合酶链反应 (RT PCR)。所有资料录入计算机进行数据分析。结果 3年监测中共调查 2 3 4 3例腹泻患儿 ,收集便样 12 11份 ,轮状病毒检出率门诊患儿和住院患儿分别为 3 1.0 %和 52 .9%。轮状病毒感染 95.0 %发生于 2岁以下儿童。每年寒冷季节流行 (11月到次年 3月 )。流行的轮状病毒G血清型依次为G1(82 .4% )、G2 (5.0 % )、G3 (3 .3 % )和G 4(0 .9% ) ,P基因型以P[8]和P[4]为常见。共检出 9种P~G结合的毒株 ,其中世界常见的 4种流行株占 75.6%。结论 轮状病毒流行毒株呈现超常多样性 。 | 孙利炜 童志礼 李丽红 章菁 陈琦 郑丽舒 刘静 谢华萍 王承训 张丽杰 Ivanoff B Glass RI Bresee JS Jiang XI Kilgore PE 方肇寅 | 2003 | 中华流行病学杂志2003，24，11： | 25 |
| 3 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 4 | ZrO_2 strengthened NiAl/Cr(Mo,Hf) composite fabricated by powder metallurgy | L.Y. Sheng a,b, J.T. Guo c, T.F. Xi a,b, B.C. Zhang c, H.Q. Ye c a PKU-HKUST ShenZhen-Hong Kong Institution, Shenzhen 518057, China b College of Engineering, Peking University, Beijing 100871, China c Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 3 |
| 5 | Adaptive output-feedback tracking of stochastic nonlinear systems显示文摘 | Ji H B Xi H S | 2006 | IEEE Transactions on Automatic Control2006，51，2： | 1 |
| 6 | Synthesis and DNA binding of spiroeyelic model compounds related to the neocarzinostatin chromophore 显示文摘 | Xi Z Jones G B Qabaja G Wright J Johnson F Goldberg I H | 1999 | Org Lett1999，1，9： | 1 |
| 7 | Laparoscopically assisted sigmoid colon vaginoplasty in women Mayer-Rokitansky-Kuster- Hauser syndrome: feasibility and short-term results 显示文摘 | Cai B Zhang JR Xi XW | 2007 | BJOG2007，114，： | 1 |
| 8 | Hidden semi-Markov model for anomaly detection显示文摘 | Tan X B Xi H S | 2008 | Applied Mathematics and Computation2008，205，2： | 1 |
| 9 | Polymorphism near the ATP2B1gene is associated with hypertension risk in East Asians:a metaanalysis involving 15 909cases and 18 529controls显示文摘 | Xi B Tang W Wang Q | 2012 | Blood Press2012，21，2： | 1 |
| 10 | Trends in general and ab- dominal obesity among Chinese children and adolescents 1993-2009显示文摘 | Liang YJ Xi B Song AQ | 2012 | Pediatr Obes2012，7，5： | 1 |
| 11 | Linear Tracking--differ- entiator and Application to Online Estimation of the Frequency of a Sinusoidal Signal with Random Noise Perturbation显示文摘 | Guo B Z Han J Q Xi F B | 2002 | International Journal of System Science2002，33，5： | 1 |
| 12 | High-mobility group protein B1 (HMGB1) is a novel biomarker for human ovarian Cancer显示文摘 | Chen J Xi B Zhao Y | 2012 | Gynecol Oncol2012，126，： | 1 |
| 13 | Fluorescence excitation- emission matrix spectroscopy with regional integration analysis for characterizing composition and transformation of dissolved organic matter in landfill leachates 显示文摘 | HE X S XI B D WEI Z M | 2011 | Journal of Hazardous Materials2011，190，123： | 1 |
| 14 | A sex-specific effect of the CYP17A1 SNP rs11191548 on blood pressure in Chinese children显示文摘 | Wu L Xi B Zhang M | 2012 | Journal of Human Hypertension2012，，26： | 1 |
| 15 | Soot in diesel combustion systems 显示文摘 | Xi J Zhong B J | 2006 | Chem Eng Technol2006，29，6： | 1 |
| 16 | TiO2 thin films prepared via adsorptive self-assembly for self-cleaning applications显示文摘 | Xi B J Verma L K Li J | 2012 | Applied Materials & Interfaces2012，，4： | 1 |
| 17 | Adaptable End Effector for Atomic Force Microscopy Based Nanomanipulation 显示文摘 | Zhang J B Xi N Li G Y | 2006 | IEEE Transactions on Nanotechnology2006，5，6： | 1 |
| 18 | Prevalence of metabolic syndrome and its influencing factors among the Chinese adults:the China Health and Nutrition Survey in 2009 显示文摘 | Xi B He D Hu Y | 2013 | Prey Med2013，57，： | 1 |
| 19 | Trends in blood pressure and hypertension among Chinese children and adoles- cents:China Health and Nutrition Surveys 1991-2004显示文摘 | Liang YJ Xi B Hu YH | 2011 | Blood Press2011，20，1： | 1 |
| 20 | Adaptive output-feedback tracking of stochastic nonlinear systems 显示文摘 | JI H B XI H S | 2006 | IEEE Transactions on Automatic Control2006，51，2： | 1 |
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