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| 1 | China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design显示文摘 | Rachel P Dreyer Xi Li Xue Du Nicholas S Downing Li Li Hai-Bo Zhang Fang Feng Wen-Chi Guan Xiao Xu Shu-Xia Li Zhen-Qiu Lin Frederick A Masoudi John A Spertus Harlan M Krumholz Li-Xin Jiang | 2016 | Chinese Medical Journal2016，，1： | 13 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Admission Glucose and In-hospital Mortality after Acute Myocardial Infarction in Patients with or without Diabetes: A Cross-sectional Study显示文摘 | Shi Zhao Karthik Murugiah Na Li Xi Li Zi-Hui Xu Jing Li Chen Cheng Hong Mao Nicholas S Downing Harlan M Krumholz Li-Xin Jiang | 2017 | Chinese Medical Journal2017，，7： | 6 |
| 4 | 中国吸烟流行趋势及其对慢性疾病的影响显示文摘中国是世界上最大的烟草消费国,有与吸烟有关的很大慢性疾疾负担。为评估中国人口吸烟的流行情况及其对慢性疾病的影响,研究者收集了2003、2008和2013年在中国进行的一系列跨部门国民健康服务调查的数据。这些调查覆盖了中国31个省、自治区、直辖市,采用多级分层整群抽样,将中国大陆划分为东部、中部和西部地区,然后以城市和农村地区为单位对每个地区的县进行抽样,入选家庭中所有15岁或以上的受访者。 | Wang M Luo X Xu S 张迪(编译) | 2020 | 中华医学杂志2020，100，24： | 4 |
| 5 | 青少年甘油磷酸胆碱代谢和心血管病的危险因素:一项队列研究显示文摘甘油磷酸胆碱(glycerophosphocholine,GPC)代谢物可调节动脉粥样硬化,从而导致心血管病风险。临床前期心血管病可能从青春期就开始。研究人员应用靶向血清脂质组学鉴定一组新的GPC,并测试在青春期时这些GPC中的任何一种是否与心血管病传统危险因子,如过量内脏脂肪、升高的血压、胰岛素抵抗和致动脉粥样硬化血脂异常相关。 | Syme C Czajkowski S Shin J Abrahamowicz M Leonard G Perron M Richer L Veillette S Gaudet D Strug L Wang Y Xu H Taylor G Paus T Bennett S Pausova Z 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 6 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 7 | Application of bis (iminophosphorane) in heterocyclic synthesis:new entries to symmetrically or unsymmetrically substituted thieno dipyrimidine -4,5 ( 3H, 6H ) -diones 显示文摘 | Ding M W Xu S Z Zhao J F | 2004 | J Org Chem2004，69，24： | 1 |
| 8 | Single wall carbon nanotubes as a drug carrier for controlled release显示文摘 | XU J YUDASAKA M KOURABA S | 2008 | Chem Phys Lett2008，461，46： | 1 |
| 9 | Layered double hydroxides as supports for intercalation and sustained release of antihypertensive drugs 显示文摘 | XIA S J NI Z M XU Q | 2008 | J Solid State Chem2008，181，： | 1 |
| 10 | The effect of the intermediate principal stress on the ground response of circular openings in rock mass显示文摘 | XU S Q YU M H | 2006 | Rock Mechanics and Rock Engineering2006，39，2： | 1 |
| 11 | Molecular determinants of response to TRAIL in killing of normal and cancer cells显示文摘 | Kim K Fisher M J Xu S Q | 2000 | Clin Cancer Res2000，6，： | 1 |
| 12 | Target isolation for SAR images显示文摘 | Xu R Kwan C M Haynes L S | 2001 | Proceedings of SPIE2001，4382，： | 1 |
| 13 | Wavelet transform domainfilters:a spatially selective noise filtration technique显示文摘 | Xu Y S Weaver J B Healy D M etal | 1994 | IEEE Trans on Image Processing1994，3，6： | 1 |
| 14 | Potent and specific genetic interference by double stranded RNA in Caenorhabditis elegans显示文摘 | Fire A Xu S Montgomery M K Kostas S A | 1998 | Nature1998，391，6669： | 1 |
| 15 | Interferon alpha down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells显示文摘 | Xu D Erickson S Szeps M | 2000 | Blood2000，96，13： | 1 |
| 16 | Dietary phytoestrogens 显示文摘 | Kurzer M S Xu X | 1997 | Annu Rev Nutr1997，17，： | 1 |
| 17 | Vanadium alloys-overview and recent results 显示文摘 | Muroga T Nagasaka T Abe K Chemov V M Matsui H Smith D L Xu Z Y Zinkle S J | 2002 | Journal of Nuclear Materials2002，，307311： | 1 |
| 18 | Studies on catalytic pyrolysis of heavy oils: reaction behaviors and mechanistic pathways 显示文摘 | Meng X H Xu C M Gao J S | 2005 | Appl Catal A Gen2005，294，： | 1 |
| 19 | Distinctive effects of CaO additive on atmospheric gasification of biomass at different temperatures 显示文摘 | XU Guangwen TAKAHIRO M TOSHIYUKI S | 2005 | Ind Eng Chem Res2005，44，15： | 1 |
| 20 | Chemical constituents of Dendrobium monili forme显示文摘 | Bi Z M Wang Z T Xu L S | 2004 | Acta Botanica Sinica2004，46，1： | 1 |
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