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| 1 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | Mutation analysis of the FOXL2 gene in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome显示文摘 | Tang SJ Wang XK Lin LX Sun Y Wang YL Yu HB | 2006 | 中国生物学文摘2006，20，4： | 15 |
| 3 | Economic burden of Parkinson's disease in a developing country: A retrospective cost analysis in Shanghai, China显示文摘 | Wang G Cheng Q Zheng R Tan YY Sun XK Zhou HY Ye XL Wang Y Wang Z Sun BM Chen SD | 2006 | 中国生物学文摘2006，20，8： | 10 |
| 4 | Stellarins F and G, two new cyclopeptides from Stellaria yunnanensis显示文摘In the previous papers,we reported the structural elucidation of stellarins A-E,fivenew cyclopeptides from the fresh roots of Stellaria yunnanensis Franch.Further chemical study on this plant led to the isolation of two other new cyclopeptides named stellarins F(l) and G(2).By a combination of 2D-NMR,enzymatic degradation and FABMS,their structures were established to be cyclo(Gly-Ala-Gly-Ser-Pro-Trp-Phe-Pro) and cyclo(Gly-Ala-Tyr-Leu-Ala),respectively. | Zhao, YR Wang, XK Zhou, J Cheng, CX Huang, XL Wu, HM | 1995 | Chinese Journal of Chemistry1995，13，6： | 3 |
| 5 | Synthesis and Characterization of Mixed Al+AlN Nanoparticles显示文摘Mixed Al+AlN nanoparticles were synthesized by an active plasma-metal reaction method. Mean particle size of the mixed Al+AlN nanoparticles is about 30-50 nm. Defects were found in some AlN particles. Moreover, the AlN ratio and its particle size in mixed Al+AIN nanoparticles obtained in different atmospheres (N2+Ar) increase with increasing N2 particle pressure, and the specific sudece areas of the mixed Al+AlN nanoparticles increase with the AlN ratio. The surface degradation of the Al+AlN exposed to air is estimated by the infrared absorption | Sun, XC Yang, MC Ye, F Sun, XK Wei, WD Yu, YD Ping, DH | 1997 | Journal of Materials Science & Technology1997，13，4： | 2 |
| 6 | Fuctional cooperation between interleukin - 17 and tumor necrosis factor - α is nediated by CCAAT/enhance -binding protein family memers显示文摘 | Ruddy MJ Wong G Liu XK | 2004 | J Biol Chem2004，279，4： | 1 |
| 7 | Huanglian, A Chinese herbal extract, inhibits cell growth by suppressing the expression of cyclin B1 and inhibiting CDC2 kinase activity in human cancer cells显示文摘 | Li XK Motwani M Tong W | 2000 | Mol Pharmacol2000，58，6： | 1 |
| 8 | Prolonged cardiac allograft survival in rats systemically injected adenovial vectors containing CTLA-4 lg-gene显示文摘 | Kita Y Li XK Ohb M | 1999 | Transplantation1999，68，6： | 1 |
| 9 | Submandibular salivary gland transfer for the prevention of radiation-induced xerostomia in patients with nasopharyngeal carcinoma:5-year outcomes显示文摘 | Liu XK Su Y Jha N | | 0，，03： | 1 |
| 10 | Pulse wave velocity is associated with metabolic syndrome components in CAPD patients显示文摘 | Zhe XW Zeng J Tian XK | 2008 | Am J Nephrol2008，28，4： | 1 |
| 11 | Influence of temperature on formaldehyde emission parameters of dry building materials 显示文摘 | Zhang YP Luo XX Wang XK | 2007 | Atmospheric Environment2007，41，32： | 1 |
| 12 | Simplified technique for heterotopic vascularized cervical heart transplantation in mice显示文摘 | Wang Q Liu Y Li XK | 2005 | Microsurgery2005，25，1： | 1 |
| 13 | Prolonged survival of rat liver allografts transfected with Fas ligand-expressing plasmid显示文摘 | Li XK Oknyama T Tamura A | 1998 | Transplantation1998，66，11： | 1 |
| 14 | Cardiac K < sub > ATP < / sub > channels in health and disease 显示文摘 | Kane GC Liu XK Yamada S | 2005 | J Mol Cell Cardiol2005，38，6： | 1 |
| 15 | MicroRNA analysis as a potential diagnostic tool for papillary thyroid carcinoma显示文摘 | Chen YT Kitabayashi N Zhou XK | 2008 | Mod Pathol2008，21，9： | 1 |
| 16 | Vascular remodel- ing versus amyloid beta-induced oxidative stress in the cerebro- vascular dysfimctions associated with Alzheimer' s disease显示文摘 | Tong XK Nicolakakis N Kocharyan A | 2005 | J Neurosci2005，25，11： | 1 |
| 17 | Treatment of pediatric spinal tuberculosis abscess with percutaneous drainage and lowdose local antituberculous therapy:apreliminary report显示文摘 | Yin XH Zhang HQ Hu XK | 2015 | Childs Nerv Syst2015，31，7： | 1 |
| 18 | Retinyl methyl ether:binding to transport proteins and effect on transcriptional regulation 显示文摘 | Sani BP Zhang XK Hill DL | 1996 | Biochem Biophys Res Commun1996，223，2： | 1 |
| 19 | Fulminant hepatitis by Fas positive livers and wild type mice grafted with Fas mutant livers 显示文摘 | Li XK Fu jinoM Sugioka A | 2001 | Transplantation2001，27，4： | 1 |
| 20 | Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer显示文摘 | Huang XM Liu XS Lin XK | 2014 | Cancer Sci2014，105，2： | 1 |
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