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| 1 | Metagenomics: Facts and Artifacts, and Computational Challenges显示文摘Metagenomics is the study of microbial communities sampled directly from their natural environment, without prior culturing. By enabling an analysis of populations including many (so-far) unculturable and often unknown microbes, metagenomics is revolutionizing the field of microbiology, and has excited researchers in many disciplines that could benefit from the study of environmental microbes, including those in ecology, environmental sciences, and biomedicine. Specific computational and statistical tools have been developed for metagenomic data analysis and comparison. New studies, however, have revealed various kinds of artifacts present in metagenomics data caused by limitations in the experimental protocols and/or inadequate data analysis procedures, which often lead to incorrect conclusions about a microbial community. Here, we review some of the artifacts, such as overestimation of species diversity and incorrect estimation of gene family frequencies, and discuss emerging computational approaches to address them. We also review potential challenges that metagenomics may encounter with the extensive application of next-generation sequencing (NGS) techniques. | John C. Wooley 叶玉珍 | 2010 | Journal of Computer Science & Technology2010，25，1： | 3 |
| 2 | A nine zone simulating moving bed for the recovery of glucose and xylose from biomass hydrolyzate显示文摘 | Wooley R Ma Z Wang N H L | 1998 | IEC Res1998，37，9： | 2 |
| 3 | Relationship of complement resistance and selected virulence factors in pathogenic avian Escherichia coli显示文摘 | Wooley R E Spears K R Brown J | 1992 | Avian Dis1992，36，3： | 2 |
| 4 | The design of sigma-delta modulation analog-to-digital converters 显示文摘 | Boser B E Wooley B A | 1988 | IEEE Journal of Solid-state Circuits1988，23，： | 1 |
| 5 | Design techniques for high-speed, high-resolution comparators显示文摘 | RAZAVI B WOOLEY B A | 1992 | IEEE J Sol Sta Circ1992，27，12： | 1 |
| 6 | Water relations of soybean leaf hairs显示文摘 | Wooley J T | 1964 | Agrono my Journal1964，56，6： | 1 |
| 7 | Aseptic loosening显示文摘 | Wooley PH Schwarz EM | 2004 | Gene Ther2004，4，： | 1 |
| 8 | Design techniques for high-speed,high-resolution comparators显示文摘 | Razavi B Wooley B A | 1992 | Solid-State Circuits IEEE Journal of1992，27，12： | 1 |
| 9 | Softwood forest thinnings as biomass source for ethanol production:a feasibility study for california 显示文摘 | Kadaml K Wooley J R Aden A | 2000 | Biotechnol Prog2000，16，： | 1 |
| 10 | A novel marine model of orthopedic wear debris associated osteolysis 显示文摘 | Ren W Yang SY Wooley PH | 2004 | Scand J Rheumatol2004，33，5： | 1 |
| 11 | Shell cross-linked nanoparticles containing hydrolytically degradable, crystal- line core domains显示文摘 | Zhang Q Remsen E E Wooley K L | 2000 | J Am Chem Soc2000，122，： | 1 |
| 12 | Cellular immune responses to orthopaedic implant materials following cemented total joint replacement显示文摘 | Wooley PH Petersen S Song Z | 1997 | J Orthop Res1997，159，3： | 1 |
| 13 | Effects of Cytokine Gene Therapy on Particulate-Induced Inflammation in the Murine Air Pouch显示文摘 | Sudha Sud Shang-You Yang Christopher H. Evans Paul D. Robbins Paul H. Wooley | 2001 | Inflammation2001，，6： | 1 |
| 14 | The design of sigma-delta modulation analog-to-digital converters 显示文摘 | Boser B E Wooley B A | 1988 | IEEE J Sol Sta Circ1988，23，6： | 1 |
| 15 | Adrenal steroid receptor immunoreactivity in cells born in the adult rat dentate gyrus显示文摘 | Cameron HA Wooley CS Gould E | 1993 | Brain Res1993，611，： | 1 |
| 16 | Total joint arthroplasty and the immune response显示文摘 | Constantine A. Toumbis John L. Kronick Paul H. Wooley Sam Nasser | 1997 | Seminars in Arthritis and Rheumatism1997，，1： | 1 |
| 17 | Metabolic and nutritional aspects of acute renal failure in critically ill patients requiring continuous renal replacement therapy显示文摘 | Wooley J A Btaiche I F Good K L | 2005 | Nutr Clin Pract2005，20，2： | 1 |
| 18 | Anti-TNF-a antibody al lows healing of joint damage in polyarthritic transgenic mice显示文摘 | Shealy D J Wooley PH Emmell E | 2002 | Arthritis Research2002，4，5： | 1 |
| 19 | Relationship of complement resistance and selected virulence factors in pathogenic avian Escherichia coli 显示文摘 | Wooley RE Spears KR Brown J | 1992 | Avian Dis1992，36，3： | 1 |
| 20 | Comb polymers prepared by ATRP from hydroxypropyl cellulose 显示文摘 | OSTMARK E HARRISSON S WOOLEY K L | 2007 | Biomacromolecules2007，8，4： | 1 |
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