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| 1 | 弥漫性中线胶质瘤,组蛋白H3-K27M突变型:47例形态学变异谱系及相关遗传学改变分析显示文摘最近发现在儿童和年轻人丘脑、桥脑和脊髓的高级别胶质瘤中存在编码组蛋白H3的亚型H3.3和H3.1的H3F3A和HIST1H3B基因体细胞突变。然而,关于发生这些肿瘤的患者和部位具体范围,以及形态学谱系和相关遗传学改变仍然不确定。本文检测47例伴组蛋白H3-K27M突变的弥漫性中线胶质瘤,包括25例男性和22例女性患者,年龄2~65岁(中位年龄14岁)。肿瘤中心位置除了位于桥脑(17例)、丘脑(15例)和脊髓(9例),还可见于第三脑室(3例)、下丘脑(1例)、松果体区(1例)和小脑(1例)。 | Solomon D A Wood M D Tihan T 李晓玲 王行富 | 2016 | 临床与实验病理学杂志2016，32，9： | 49 |
| 2 | CO_2浓度变化和气候变化对中国陆地生态系统净初级生产及其平衡的影响(英文)显示文摘本文应用陆地生态系统模型(TEM,4.0)对中国陆地生态系统在目前气候下的净初级生产力,以及在CO2浓度增加和气候变化后的净初级生产力的变化进行了预测。气候变化模型采用三种大气环流模型生成,即:GISS、GFDL和OSU模型。在当前气候条件和CO2浓度(312.5×10-6)下,TEM模型预测中国陆地生态净初级生产力为3,653TgC·a-1(1012gC·a-1)。温带常绿阔叶林是生产力最高的生物区,占有中国净初级生产力的最大比例。NPP的空间格局主要与降水量和温度的空间分布相关联。中国陆地生态系统的年净初级生产力对CO2浓度和气候的变化敏感。在陆地区域尺度上,其年净初级生产力仅在CO2浓度上升至519×10-6的情况下可增加6.0%(219TgC·a-1)。在气候变化而无CO2浓度变化的条件下,净初级生产力的响应在GISS气候方案下表现为1.5%(54.8TgC·a-1)的降低,在GFDL-q气候方案下表现为8.4%(306.9TgC·a-1)的增加。在气候和CO2浓度均发生变化的情况下,净初级生产力有较大程度的增加,在GISS气候方案下的增加比例为18.7%(683TgC·a-1),在GFDL-q气候? | Xiao 1,2 , X., J.M.Melillo 1, D.W.Kicklighter 1, Y.Pan 1, A.D.McGuire 3 and J.Helfrich 1 ( 1The Ecosystems Center, Marine Biological Laboratory, Woods Hole, MA 02543, USA) ( 2 The Joint Program on the Science and Policy of Globa | 1998 | 植物生态学报1998，22，2： | 35 |
| 3 | GDNF-Enhanced Axonal Regeneration and Myelination Following Spinal Cord Injury is Mediated by Primary Effects on Neurons显示文摘我们先前研究表明胶质细胞源性神经营养因子(GDNF)联合施万细胞移植能促进脊髓损伤后轴突再生和髓鞘形成。然而,GDNF介导这一过程的细胞靶点尚不清楚。在此,我们报道了GDNF可增加在体再生轴突的数目和直径,并促进体外背根神经节神经元的轴突向外生长,提示GDNF对神经元有直接作用。在施万细胞-背根神经节神经元共培养下,GDNF显著增加施万细胞生成的髓鞘数目;GDNF处理对孤立培养的施万细胞增殖无作用,但可促进已与神经轴突有突触联系的施万细胞增殖;GDNF可增加孤立施万细胞中分子量为140kDa的神经细胞黏附分子(NCAM)的表达,但对黏附分子L1表达或神经营养因子NGF、NT3及BDNF分泌没有影响。总之,这些结果支持假设:GDNF提高轴突再生和施万细胞髓鞘形成主要是通过GDNF对神经元的直接作用介导的,并且提示GDNF联合施万细胞移植可能是促进脊髓损伤后轴突再生和髓鞘形成的有效策略之一。 | LIQUN ZHANG ZHENGWEN MA GEORGE M. SMITH XUEJUN WEN YELENA PRESSMAN PATRICK M. WOOD AND XIAO-MING XU | 2009 | 神经损伤与功能重建2009，4，4： | 25 |
| 4 | 城市化对杭州市鸟类营巢集团的影响显示文摘为了了解城市化对鸟类营巢集团的影响,2007年3月至2007年8月,沿城市化梯度在杭州地区的城区、城乡结合区、农田区、农林交错区和自然林区等类型栖息地内设置3000m长、100m宽的样线各18条,共计90条;并对其鸟类物种与群落营巢集团进行调查。调查共记录到繁殖鸟类96种,根据鸟类营巢位置可将其分为林冠枝干营巢集团、灌草丛营巢集团、林冠枝干/灌草丛营巢集团、自然洞穴营巢集团、人工建筑营巢集团、自然洞穴/人工建筑营巢集团地面营巢集团、水面营巢集团和寄生集团共9种。进一步分析显示,随城市化程度提高,鸟类营巢集团的数目呈整体下降趋势,而各集团的物种数也基本呈下降趋势。但是,不同的营巢集团对城市化的反应存在差异,导致其物种组成在群落中比例的明显变化。城市化程度的提高使树冠筑巢鸟、灌丛筑巢鸟、地面筑巢鸟及自然洞穴筑巢鸟在群落中所占的比例明显下降,其中地面筑巢鸟最为敏感,灌丛筑巢鸟次之。同时,自然洞穴/人工建筑集团的鸟类在群落中的比例却随着城市化程度的提高明显上升。各营巢集团之所以对城市化做出不同反应,是因为它们对筑巢地资源利用方式不同。此外,还发现植被盖度、人工设施面积、至市中心距离以及人为干扰等因素均可对鸟类营巢集团结构产生影响,但不同类型的营巢集团对上述因素的反应各异。 | 李鹏 张竞成 李必成 Chris Wood 蒋萍萍 丁平 | 2009 | Zoological Research2009，30，3： | 22 |
| 5 | Organic carbon stratification and size distribution of three typical paddy soils from Taihu Lake region,China显示文摘为中国的持续农业开发现实主义的土壤碳(C) 隐遁策略依靠数量,保留和在水稻土存储的 C 的周转率的精确估计。到日期的可得到的 C 估计是主要为 tilled 和灌溉洪水的表面表层土(ca。30 厘米) 。自从器官的碳(SOC ) 通常显示出的土壤,如此的估计不能被用来外推到 100 厘米的土壤深度有深度的锋利的减少。在这研究,合成土壤样品在泰胡·莱克区域从三代表性的水稻土在几深度被收集到 100 厘米,中国。在侧面玷污器官的碳分发,在总数尺寸,部分被决定。当 SOC 与深度指数地减少了到 100 厘米时,结果显示出那,全部的 SOC 的一个实质的比例(30%40%) 在 30 厘米深度下面被存储。在充实碳的稻表层土, SOC 被发现在 2 0.25 和 0.25 0.02 公里总数尺寸部分优先地积累。? 粗糙的微总数的部分的 13C 分析证明在稻表层土的 C 层化的高度与打火机的出现一致 ? 1313C 在上面 30 厘米深度。这些结果建议在侧面以内的层化关于泥土和铁 oxyhydrates 分布与水稻土的不同 pedogenetical 类型改变的那 SOC。在水稻土系统的总数的沙大小的部分可以在碳隐遁和周转起一个很重要的作用,对另外的学习农业系统不一样。 | PAN Genxing WU Laosheng LI Lianqing ZHANG Xuhui GONG Wei WOOD Yvonne | 2008 | Journal of Environmental Sciences2008，20，4： | 21 |
| 6 | Endoscopic retrograde cholangiopancreatography associated pancreatitis:A 15-year review显示文摘The aim of this article is to review the literature regarding post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis.We searched for and evaluated all articles describing the diagnosis,epidemiology,pathophysiology,morbidity,mortality and prevention of post-ERCP pancreatitis(PEP) in adult patients using the PubMed database.Search terms included endoscopic retrograde cholangiopancreatography,pancreatitis,ampulla of vater,endoscopic sphincterotomy,balloon dilatation,cholangiography,adverse events,standards and utilization.We limited our review of articles to those published between January 1,1994 and August 15,2009 regarding human adults and written in the English language.Publicat ions from the reference sections were reviewed and included if they were salient and fell into the time period of interest.Between the dates queried,seventeen large(> 500 patients) prospective and four large retrospective trials were conducted.PEP occurred in 1-15 in the prospective trials and in 1-4 in the retrospective trials.PEP was also reduced with pancreatic duct stent placement and outcomes were improved with endoscopic sphincterotomy compared to balloon sphincter dilation in the setting of choledocholithiasis.Approximately 34 pharmacologic agents have been evaluated for the prevention of PEP over the last f ifteen years in 63 trials.Although 22 of 63 trials published during our period of review suggested a reduction in PEP,no pharmacologic therapy has been widely accepted in clinical use in decreasing the development of PEP.In conclusion,PEP is a well-recognized complication of ERCP.Medical treatment for prevention has been disappointing.Proper patient selection and pancreatic duct stenting have been shown to reduce the complication rate in randomized clinical trials. | Kevin E Woods Field F Willingham | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，5： | 20 |
| 7 | Sagittal plane analysis of the spine and pelvis in adult idiopathic scoliosis显示文摘在那里的背景是在有它联系到临床的结果的脊柱侧凸的病人的 sagittal spinopelvic 排列的重要性的增加的识别。然而,在成年自发的脊柱侧凸病人在 sagittal spinopelvic 排列看见的变化糟糕被定义。这研究被进行在成年自发的脊柱侧凸 patients.Methods 评估骨盆和脊骨的 sagittal 排列脊骨和骨盆的 sagittal 参数在 124 个病人的侧面的站的拍被分析(意味着年龄 47.4 年)与成年自发的脊柱侧凸包括胸的驼背( TK ), thoracolumbar 连接驼背( TLJ ),腰部的脊柱前凸( LL ),骨盆的发生( PI ),骶骨斜坡( SS ),骨盆倾斜(磅)并且 C7 铅锤线( C7PL )。病人根据年龄被划分成三个组:20-40 年, 41-64 年,和 65 年。参数与在正常成年人和青春期的自发的脊柱侧凸(AIS ) 的那些相比是病人。在象年龄一样的所有参数和 sagittal 参数之间的关系是在有成年自发的脊柱侧凸的病人的 PI 是的 analyzed.Results 58.1 ? 潢吗? | LI Wei-shi LI Gang CHEN Zhong-qiang Kirkham B Wood | 2010 | Chinese Medical Journal2010，，21： | 19 |
| 8 | Neuropathophysiology of functional gastrointestinal disorders显示文摘The investigative evidence and emerging concepts in neurogastroenterology implicate dysfunctions at the levels of the enteric and central nervous systems as underlying causes of the prominent symptoms of many of the functional gastrointestinal disorders. Neurogastroenterological research aims for improved understanding of the physiology and pathophysiology of the digestive subsystems from which the arrays of functional symptoms emerge. The key subsystems for defecation-related symptoms and visceral hyper- sensitivity are the intestinal secretory glands, the musculature and the nervous system that controls and integrates their activity. Abdominal pain and discomfort arising from these systems adds the dimension of sensory neurophysiology. This review details current concepts for the underlying pathophysiology in terms of the physiology of intestinal secretion, motility, nervous control, sensing function, immuno-neural communication and the brain-gut axis. | Jackie D Wood | 2007 | World Journal of Gastroenterology2007，13，9： | 17 |
| 9 | Stroke-induced immunosuppression and poststroke infection显示文摘Infections occur commonly after stroke and are strongly associated with an unfavourable functional outcome of these patients.Approaches for effective management of poststroke infection remain scarce,presenting an urgent need for preventive anti-infection strategies for patients who have suffered a stroke.Emerging evidence indicates that stroke impairs systemic immune responses and increases the susceptibility to infections,suggesting that the modification of impaired immune defence could be beneficial.In this review,we summarised previous attempts to prevent poststroke infections using prophylactic antibiotics and the current understanding of stroke-induced immunosuppression.Further elucidation of the immune mechanisms of stroke will pave the way to tailored design of new treatment to combat poststroke infection via modifying the immune system. | Kaibin Shi Kristofer Wood Fu-Dong Shi Xiaoying Wang Qiang Liu | 2018 | Stroke & Vascular Neurology2018，3，1： | 17 |
| 10 | 塞来昔布治疗骨关节炎的随机对照试验显示文摘目的 :比较塞来昔布、萘普生以及安慰剂在治疗膝关节骨关节炎时的疗效、安全性。方法 :10 0 3名有症状的膝关节骨关节炎患者随机接受塞来昔布 5 0 ,10 0 ,2 0 0mg ,bid ;萘普生 5 0 0mg ,bid或安慰剂 12周。患者在停用既往NSAID药或止痛治疗后 2~ 7d以及服用受试药物治疗后 2 ,6 ,12周 ,根据标准疗效判定方法进行评估。结果 :塞来昔布在改善骨关节炎的症状和体征上有显著效果。在治疗后的 2d内疼痛明显缓解 ,最大抗炎和镇痛作用出现在 2周内并持续至 12周。各剂量的塞来昔布与安慰剂比较均有效 ,但 5 0mg ,bid的剂量效果较差 ;较大剂量的塞来昔布 (10 0和 2 0 0mg ,bid)疗效相似 ,所观察到的改善程度与萘普生 5 0 0mg ,bid相当。各剂量的塞来昔布和萘普生均有良好的耐受性。结论 :COX 2抑制剂塞来昔布是治疗骨关节炎的有效药物 ,对骨关节炎临床症状和体征的改善与萘普生相当。 | Bensen WG Fiechtner JJ Mcmillen JI Zhao WW Yu SS Woods EM Hubbard RC Isakson PC Verburg KM Geis GS | 2000 | 中国新药杂志2000，9，8： | 17 |
| 11 | 特立独行的第二脑--肠神经系统显示文摘肠神经系统(enteric nervous system, ENS)由分布在肠壁的黏膜下及肌间两个神经丛组成,能独立地控制和调节胃肠的消化和吸收功能,被称为机体的第二脑(the second brain)或肠脑(gut brain)。ENS相对于中枢神经系统(central nervous system,CNS),在神经元的性能和环路上有着明显的独特性。ENS和CNS通过交感和副交感神经以及外周初级感觉神经组成反馈环路(脑-肠轴),影响个体的情绪、食欲和行为等其他功能。肠神经功能异常引起的胃肠功能紊乱不仅导致消化功能异常,还引起内脏痛及情绪和行为异常,如肠易激综合征(irritable bowel syndrome, IBS),严重影响病人的生活质量。然而,从世界范围来看,对ENS研究的深入程度和投入规模远低于对CNS的研究,在中国尤其如此。回顾ENS的研究历史,一个突出的问题是忽视了ENS的神经元及其神经网络和功能活动的特异性。本文将简介ENS结构和功能,举例重点阐述ENS独有的特性和重要意义,以期使更多的基础和临床研究领域的同仁们加深对ENS独特性的认识,促进ENS和相关疾病研究的进展。 | 李军华 段睿 李俍 WOOD Jackie D 望西玉 舒友生 王过渡 | 2020 | 生理学报2020，72，3： | 17 |
| 12 | Interactions between hotspots and the Southwest Indian Ridge during the last 90 Ma:Implications on the formation of oceanic plateaus and intra-plate seamounts显示文摘This study investigates the relationship between the hotspot-ridge interaction and the formation of oceanic plateaus and seamounts in the Southwest Indian Ocean.We first calculated the relative distance between the Southwest Indian Ridge (SWIR) and relevant hotspots on the basis of models of plate reconstruction,and then calculated the corresponding excess magmatic anomalies of the hotspots on the basis of residual bathymetry and Airy isostasy.The results reveal that the activities of the Marion hotspot can be divided into three main phases:interaction with the paleo-Rodrigues triple junction (73.6-68.5 Ma),interaction with the SWIR (68.5-42.7 Ma),and intra-plate volcanism (42.7-0 Ma).These three phases correspond to the formation of the eastern,central,and western parts of the Del Cano Rise,respectively.The magnitude and apparent periodicity of the magmatic volume flux of the Marion hotspot appear to be dominated by the hotspot-ridge distance.The periodicity of the Marion hotspot is about 25 Ma,which is much longer than that of the Hawaii and Iceland hotspots (about 15 Ma). | ZHANG Tao 1,2,3,4,LIN Jian 5 & GAO JinYao 3,4 1 Institute of Geodesy and Geophysics,Chinese Academy of Sciences,Wuhan 430077,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 The Second Institute of Oceanography,State Oceanic Administrator,Hangzhou 310012,China 4 Key Laboratory of Submarine Geosciences,State Oceanic Administrator,Hangzhou 310012,China 5 Department of Geology and Geophysics,Woods Hole Oceanographic Institution,Woods Hole,MA 02543,USA | 2011 | Science China Earth Sciences2011，54，8： | 16 |
| 13 | 成人特发性脊柱侧凸患者脊柱-骨盆矢状位平衡分析显示文摘目的:分析不同类型成人特发性脊柱侧凸(IS)患者的脊柱-骨盆矢状位平衡情况。方法:回顾分析2002年4月2009年4月收治的83例成人IS患者,男16例,女67例,年龄2084岁,平均43岁。在全脊柱站立位X线正侧位片(包括双侧髋关节)上测量侧凸Cobb角、胸椎后凸角(TK)、胸腰段后凸角(TLJ)、腰椎前凸角(LL)、骨盆入射角(PI)、骶骨倾斜角(SS)、骨盆倾斜角(PT)以及C7铅垂线与S1后上缘的水平距离(SVA)。将患者分为胸弯组和腰弯组,比较两组患者的脊柱-骨盆矢状位参数,分析各参数间的相关性及各参数与年龄的相关性。结果:胸弯组共39例,平均年龄40.9岁,主弯角度平均45.8°;腰弯组共44例,平均年龄44.8岁,主弯角度平均39.5°。两组患者的年龄无统计学差异(P〉0.05)。两组的TK、TLJ、LL、PI、SS、PT均无统计学差异(P〉0.05),但腰弯组的SVA明显大于胸弯组(P〈0.05)。在≤40岁患者中,胸弯组和腰弯组患者的脊柱-骨盆矢状位序列无统计学差异(P〉0.05);在〉40岁患者中,腰弯组患者SVA和PT大于胸弯组(P〈0.05),余参数两组间无统计学差异(P〉0.05)。胸弯组9例(23.1%)出现脊柱失平衡,其中7例为负向失平衡;腰弯组12例(27.3%)出现脊柱失平衡,其中8例为正向失平衡。两组的LL与TK、SS有相关性,PI与PT、SS有相关性,SVA与LL、SS、PT有相关性,年龄与SVA、PT有相关性。与胸弯组不同,腰弯组患者的PI与LL无相关性,而年龄与LL、SS有相关性,PT与LL、SS有相关性。结论:成人IS中,胸弯和腰弯患者的骨盆形态无差别,骨盆与脊柱的矢状位序列密切相关,年龄与躯干平衡相关。胸弯患者易出现脊柱负向失平衡,而腰弯患者更易出现脊柱正向失平衡。 | 李危石 陈仲强 Kirkham B Wood | 2011 | 中国脊柱脊髓杂志2011，21，3： | 15 |
| 14 | Role of quorum sensing in bacterial infections显示文摘Quorum sensing(QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed. | Israel Castillo-Juárez Toshinari Maeda Edna Ayerim Mandujano-Tinoco María Tomás Berenice Pérez-Eretza Silvia Julieta García-Contreras Thomas K Wood Rodolfo García-Contreras | 2015 | World Journal of Clinical Cases2015，3，7： | 15 |
| 15 | 基质诱导的自体软骨细胞移植术修复膝关节软骨缺损10例术后2年的随访显示文摘目的应用基质诱导的自体软骨细胞移植技术(MACI,Genzyme,America)对膝关节软骨损伤的患者进行治疗,通过对患者进行术后2年的随访分析,评价MACI治疗的安全性和有效性。方法从2004年至2008年11月,对10例患者实施MACI手术。患者平均年龄34.9岁(14~57岁),缺损的平均面积(3.69±2.62)cm2/处(0.4~8cm2,n=20)。MACI技术是从患者非负重区取自体关节软骨,进行体外消化并分离出软骨细胞,培养扩增后接种在Ⅰ/Ⅲ型双层胶原膜上。移植前按缺损的部位修剪成相应形状,用生物蛋白胶将胶原膜粘贴在关节软骨缺损处。分别于术前1周、术后3个月、6个月、1年和2年使用KOOS评分问卷进行临床康复效果的评估并进行术后核磁共振的检测(MRI)。此外,术后对2例患者进行了3次关节镜检查和2次组织学检测。结果 10例患者术后均未发生并发症及与手术相关的不良事件。患者术后3个月KOOS评分显示疼痛明显改善(P<0.05);术后6个月KOOS评分显示:疼痛、症状、日常生活、运动及娱乐和生活质量5项均明显升高,5项评分间有统计学差异(P<0.05)。术后1年和2年患者的情况得到了持续的改善(P<0.05)。患者术后3个月的MRI显示软骨缺损部位得到大部分填充和修复;6个月移植软骨基本与周围软骨完全整合;1年后修复组织呈等信号,软骨下骨髓水肿消失;2年后大部分患者软骨修复组织信号与周围组织信号强度一致,软骨下骨无骨髓水肿。术后15个月和2年的组织学检查显示新生的软骨组织以透明软骨为主。MACI手术一般都能在2h内完成,术中出血量小于100ml。结论 MACI技术是修复关节软骨缺损安全、可靠和有效的治疗措施,具有操作简单、手术时间短和术中出血量少等特点。 | 张仲文 侯世科 杨造成 唐子滨 钟心 杨传铎 白建鹏 郑铭豪 David Wood | 2010 | 中华关节外科杂志(电子版)2010，4，6： | 14 |
| 16 | Lancet:世界心脏联盟全球心血管疾病预防展望显示文摘动脉粥样硬化性心血管疾病是世界头号致死致残因素,不成比例地影响着中低收入国家(LMIC)的居民。二十世纪六七十年代,心血管疾病被视为高收入国家的常见病,此后通过采取更好的预防措施(如改变生活方式、控制风险因素等),并广泛应用简单有效的紧急事件处理和二级预防措施,心血管疾病的年龄标准化死亡率得以减半。然而,即便在发达国家,所采取的这些行之有效的策略仍远远不够,如果在大多数高收入国家中推广,未来二十年心血管疾病的发生率将进一步降低。 | Yusuf S Wood D Ralston J Reddy KS | 2015 | 疾病监测2015，30，5： | 14 |
| 17 | 南方阔叶树材干燥初期应变特点的研究显示文摘在不同温度和平衡含水率条件下研究南方阔叶树材干燥初期应变特点。试验结果表明,干燥初期表层呈现伸张弹性应变和塑性应变,内层为压缩应变,伸张弹性应变的最大值是产生表裂的主要原因,塑性应变而引起的表层固定变形是产生内裂的原因。弹性和塑性应变受平衡含水率的影响较大,并且与含水率梯度存在相关关系、干燥初期阶段的延续时间,可由表层达到最大伸张应变时的含水率与初含水率的比值来确定。 | Guo Yanming et al. (Research Institute of Wood Industry,CAF,Beijing 100091) | 1995 | 木材工业1995，9，4： | 13 |
| 18 | Fingolimod alters inflammatory mediators and vascular permeability in intracerebral hemorrhage显示文摘Intracerebral hemorrhage(ICH) leads to high rates of death and disability. The pronounced infl ammatory reactions that rapidly follow ICH contribute to disease progression. Our recent clinical trial demonstrated that oral administration of an immune modulator fingolimod restrained secondary injury derived from initial hematoma,but the mechanisms remain unknown. In this study,we aim to investigate the effects of fingolimod on inflammatory mediators and vascular permeability in the clinical trial of oral fingolimod for intracerebral hemorrhage(ICH). The results showed that fingolimod decreased the numbers of circulating CD4^+ T,CD8^+ T,CD(19)^+B,NK,and NKT cells and they recovered quickly after the drug was stopped. The plasma ICAM level was decreased and IL-10 was increased by fingolimod. Interestingly,fingolimod protected vascular permeability as indicated by a decreased plasma level of MMP9 and the reduced r T1%. In conclusion,modulation of systemic inflammation by fingolimod demonstrates that it is an effective therapeutic agent for ICH. Fingolimod may prevent perihematomal edema enlargement by protecting vascular permeability. | Yu-Jing Li Guo-Qiang Chang Yuanchu Liu Ye Gong Chunsheng Yang Kristofer Wood Fu-Dong Shi Ying Fu Yaping Yan | 2015 | Neuroscience Bulletin2015，31，6： | 12 |
| 19 | 口服抗栓药物预防非瓣膜性房颤患者的卒中:美国心脏协会/美国卒中协会的科学建议显示文摘成年房颤患者的卒中发生率,依据合并症和既往脑血管事件史,为每年1%~20%不等(平均每年为4.5%)。对卒中风险的分层非常重要,因为用抗栓药降低房颤导致卒中的主要风险是出血。如华法令在减少缺血性事件风险的同时,每年有1%~12% | 戴若莲 糜建华 华驾略 董荃 苏爱萍 李焰生 Furie KL Goldstein LB Albers GW Khatri P Neyens R Turakhia MP Turan TN Wood KA | 2012 | 神经病学与神经康复学杂志2012，9，3： | 12 |
| 20 | Management of postoperative instrumented spinal wound infection显示文摘 | Fang Xiu-tong Wood, Kirkham B. | 2013 | Chinese Medical Journal2013，，20： | 12 |
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