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| 1 | Printed microelectrode arrays on soft materials:from PDMS to hydrogels显示文摘Microelectrode arrays(MEAs)provide promising opportunities to study electrical signals in neuronal and cardiac cell networks,restore sensory function,or treat disorders of the nervous system.Nevertheless,most of the currently investigated devices rely on silicon or polymer materials,which neither physically mimic nor mechanically match the structure of living tissue,causing inflammatory response or loss of functionality.Here,we present a new method for developing soft MEAs as bioelectronic interfaces.The functional structures are directly deposited on PDMS-,agarose-,and gelatin-based substrates using ink-jet printing as a patterning tool.We demonstrate the versatility of this approach by printing high-resolution carbon MEAs on PDMS and hydrogels.The soft MEAs are used for in vitro extracellular recording of action potentials from cardiomyocyte-like HL-1 cells.Our results represent an important step toward the design of next-generation bioelectronic interfaces in a rapid prototyping approach. | Nouran Adly Sabrina Weidlich Silke Seyock Fabian Brings Alexey Yakushenko Andreas Offenhausser Bernhard Wolfrum | 2018 | npj Flexible Electronics2018，2，1： | 3 |
| 2 | Significance of an additional unenhanced scan in computed tomography angiography of patients with suspected acute aortic syndrome显示文摘AIM To assess potential benefits of an additional unenhanced acquisition in computed tomography angiography(CTA) in patients with suspected acute aortic syndrome(AAS).METHODS A total of 103 aortic CTA(non-electrocardiography-gated, 128 slices) performed due to suspected AAS were retrospectively evaluated for acute aortic dissection(AAD), intramural hematoma(IMH), or penetrating aortic ulcer(PAU). Spiral CTA protocol consisted of an unenhanced acquisition and an arterial phase. If AAS was detected, a venous phase(delay, 90 s) was added. Images were evaluated for the presence and extent of AAD, IMH, PAU, and related complications. The diagnostic benefit of the unenhanced acquisition was evaluated concerning detection of IMH.RESULTS Fifty-six(30% women; mean age, 67 years; median, 68 years) of the screened individuals had AAD or IMH. A triphasic CT scan was conducted in 76.8%(n =43). 56% of the detected AAD were classified as Stanford type A, 44% as Stanford type B. 53.8% of the detected IMH were classified as Stanford type A, 46.2% as Stanford type B. There was no significant difference in the involvement of the ascending aorta between AAD and IMH(P = 1.0) or in the average age between AAD and IMH(P = 0.548), between Stanford type A and Stanford type B in general(P = 0.650) and between Stanford type A and Stanford type B within the entities of AAD and IMH(AAD: P = 0.785; IMH: P = 0.146). Only the unenhanced acquisitions showed a significant density difference between the adjacent lumen and the IMH(P = 0.035). Subadventitial hematoma involving the pulmonary trunk was present in 5 patients(16%) with Stanford A AAD. The difference between the median radiation exposure of a triphasic(2737 mGy*cm) compared to a biphasic CT scan(2135 mGy*cm) was not significant(P = 0.135).CONCLUSION IMH is a common and difficult to detect entity of AAS. An additional unenhanced acquisition within an aortic CTA protocol facilitates the detection of IMH. | Nikolaos Panagiotopoulos Felix Drüschler Martin Simon Florian M Vogt Sebastian Wolfrum Steffen Desch Doreen Richardt Jorg Barkhausen Peter Hunold | 2018 | World Journal of Radiology2018，10，11： | 2 |
| 3 | Apolipoprotein M is required for preβ-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis显示文摘 | Wolfrum C Poy MN Stoffel M | 2005 | Nat Med2005，11，4： | 1 |
| 4 | Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis显示文摘 | WOLFRUM C POY M N STOFFEL M | 2005 | Nat Med2005，11，： | 1 |
| 5 | Foxa2 activity increases plasma high density lipoprotein levels by regulating apolipoprotein M 显示文摘 | Wolfrum C Howell J J Ndungo E | 2008 | J Biol Chem2008，283，16： | 1 |
| 6 | Endothelium-dependent effects of statins 显示文摘 | Wolfrum S Jensen KS Liao JK | 2003 | Artefioscler Thromb Vasc Biol2003，23，5： | 1 |
| 7 | Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis显示文摘 | Wolfrum C Poy MN Stoffel M | 2005 | Nat Med2005，11，4： | 1 |
| 8 | Apolipoprotein M is required for pre -HDL formation and cholesterol efflux to HDL and protects against atherosclerosis显示文摘 | Christian Wolfrum Matthew N Poy Markus Stoffel | 2005 | Nature Medicine2005，11，4： | 1 |
| 9 | Mild therapeutic hypothermia after cardiac arrest-a nationwide survey on the implementation of the ILCOR guidelines in German intensive care units 显示文摘 | WOLFRUM S RADKE P W PISCHON T | 2007 | Resuscitation2007，72，2： | 1 |
| 10 | Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha- and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus 显示文摘 | Wolfrum C Borrmann CM Borchers T | 2001 | Proc Natl Acad Sci USA2001，98，5： | 1 |
| 11 | Mild therapeutic hypother- mia after cardiac arrest-a nationwide survey on the implementation of the ILCOR guidelines in German intensive care units 显示文摘 | WolfrumS Radke PW Pischon T | 2007 | Re- suscitation2007，72，2： | 1 |
| 12 | Sequence - specif- ic peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activa- tion and inhibit the growth of tumor cells 显示文摘 | Berger C Nagel - Wolfrum K Kunz C | 2003 | J Biol Chem2003，278，37： | 1 |
| 13 | 显示文摘 | Wolfrum E J Huang J Blake D M | 2002 | Environmental Scientific Technology2002，36，： | 1 |
| 14 | Variation of liver-type fatty acid binding protein content in the human hepatoma cell line HepG2 by peroxisome proliferators and antisense RNA affects the rate of fatty acid uptake 显示文摘 | Wolfrum C Buhlmann C Roll B | 1999 | Biochim Biophys Acta1999，1437，2： | 1 |
| 15 | Calcitonin gene related peptide mediates cardioprotection by remote preconditioning显示文摘 | Wolfrum S Nienstedt J Heidbreder M | | 0，，13： | 1 |
| 16 | Mechanisms and optimiza- tion of in vivo delivery of lipophihc siRNAs 显示文摘 | Wolfrum C Shi S Jayaprakash KN | 2007 | Nat Biotechnol2007，25，10： | 1 |
| 17 | Apolipoprotein M is required for pre β- HDL formation and cholesterol efflux to HDL and protects against atherosclerosis 显示文摘 | Wolfrum C Poy MN Stoffel M | 2005 | Nat Med2005，11，4： | 1 |
| 18 | A family with severe insulin resistance and diabetes due to a mutation in AKT2显示文摘 | GEORGE S ROCHFORD JJ WOLFRUM C et ol | 2004 | Science2004，304，5675： | 1 |
| 19 | Foxa2 activity increases plasma high density lipoprotein levels by regulating apolipoprotein M显示文摘 | Wolfrum C Howell JJ Ndungo E | 2008 | J Biol Chem2008，283，16： | 1 |
| 20 | Calcitonin gene related peptide mediates cardioprotection by remote precondi- tioning 显示文摘 | Wolfrum S Nienstedt J Heidbreder M | 2005 | Regul Pept2005，127，13： | 1 |
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