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| 1 | Suppression of Astroglial Scar Formation and Enhanced Axonal Regeneration Associated with Functional Recovery in a Spinal Cord Injury Rat Model by the Cell Cycle Inhibitor Olomoucine显示文摘Objective:To determine if a cell cycle inhibitior, olomoucine, would decrease neuronal cell death, limit astroglial proliferation and production of inhibitory CSPGs, and eventually enhance the functional compensation after SCI in rats. Methods: Three were used as un-operated controls and twelve as sham operated controls. Following spinal cord injury, 48 rats were randomly and blindly assigned to either olomoucine (n=24) or vehicle treatment (n=24) groups. Results: Up-regulations of cell cycle components were closely associated with neuronal cell death and astroglial proliferation as well as the production of CSPGs after SCI. Meanwhile, administration of olomoucine, a selective cell cycle kinase (CDK) inhibitor, has remarkably reduced the up-regulated cell cycle proteins and then decreased neuronal cell death, astroglial proliferation as well as accumulation of CSPGs. More importantly, the treatment with olomoucine has also increased expression of growth-associated proteins-43 (GAP-43), reduced the cavity formation, and improved functional deficits. Conclusion: Suppressing astroglial cell cycle in acute spinal cord injuries is beneficial to axonal growth. in turn, the future therapeutic strategies can be designed to achieve efficient axonal regeneration and functional compensation after traumatic CNS injury. | 宋宇锋 YU Zhi-yuan XIE Min-jie BU Bi-tao WITTE OW WANG Wei | 2006 | 神经损伤与功能重建2006，1，2： | 21 |
| 2 | Long-term anticonvulsant therapy leads to low bone mineral density-evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells显示文摘 | Feldkamp J Becker A Witte OW | 2000 | Exp Clin Endocrinol Diabetes2000，108，1： | 1 |
| 3 | Temporal profile of connexin 43 expression after photothrombotic lesion in rat brain 显示文摘 | Haupt C Witte OW Frahm C | 2007 | Neuroscience2007，144，： | 1 |
| 4 | Long-term anticonvulsant therapy leads to low bone mineral density evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells显示文摘 | Feldkamp J Becker A Witte OW | 2000 | Exp Clin Endocrinol Diabetes2000，108，1： | 1 |
| 5 | Recurrent posterior reversible encephalopathy syndrome (PRES)显示文摘 | Hagemann G Ugur T Witte OW | 2004 | J Hum Hypertens2004，18，4： | 1 |
| 6 | Bilateral vertebral artery dissection after chi- ropractic maneuver显示文摘 | Preul C Joachimski F Witte OW Isenmann S | 2010 | Clin Neuroradiol2010，20，4： | 1 |
| 7 | Photothrombotic infarct impairs experience- dependent plasticity ira neighboring cortex 显示文摘 | Jablonka JA Witte OW Kossut M | 2007 | Neuroreport2007，18，2： | 1 |
| 8 | Functional differentiation of multiple perilesional zones after focal cerebral ischemia显示文摘 | Witte OW Bidmon HJ Schiene K | 2000 | J Cereb Blood Flow Metab2000，20，8： | 1 |
| 9 | Functional Differentiation of Multiple Perilesional Zones After Focal Cerebral Ischemia显示文摘 | WITTE OW BIDMON HJ SCHIENE K | 2000 | J Cereb Blood Flow Metab (S0271-678X)2000，20，8： | 1 |
| 10 | Temporal profile of Connexin 43 expression after photothrombotic lesion in rat brain 显示文摘 | Haupt C Witte OW Frame C | 2007 | Neuroscience Vol2007，144，2： | 1 |
| 11 | Upregulation of Connexin43 in theglial scar following photothrombotic ischemic injury显示文摘 | Haupt C Witte OW Frahm C | 2007 | Mol Cell Neurosci2007，35，1： | 1 |
| 12 | Pharmacological Reduction of Electrophysiological Diaschisis after Photothrombotic Ischemia in Rat Neocortex显示文摘 | BUCHKREMER-RATZMANN I WITTE OW | 1997 | Eur J Pharmacol(S0014 - 2999)1997，320，23： | 1 |
| 13 | Widespread up-regulation of NMDA receptors after focal photothrombotic lesion in rat brain显示文摘 | Que M Schiene K Witte OW | 1999 | Neurosci lett1999，273，2： | 1 |
| 14 | Directed spatial potassium redistribution in rat neocortex显示文摘 | Holthoff K Witte OW | 2000 | Glia2000，29，： | 1 |
| 15 | Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion 显示文摘 | McGuire RE Schroeter M Jander S Witte OW Stoll G | 1994 | J Neuroimmunol1994，55，2： | 1 |
| 16 | GABA neurons survive focal ischemic injury显示文摘 | Haupt C Witte OW | 2004 | Neuroscience2004，127，： | 1 |
| 17 | Photothrombotic infarct impairs experience-dependent plasticity in neighboring cortex 显示文摘 | Jablonka JA Witte OW Kossut M | 2007 | Neuroreport2007，18，2： | 1 |
| 18 | Directed spatial potassium redistribution in rat neocortex 显示文摘 | Witte OW | 2000 | Glia2000，29，3： | 1 |
| 19 | Long-term anticonvulsant therapy leads to low bone mineral densityevidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells显示文摘 | Feldkamp J Becker A Witte OW | 2000 | Exp Clin Endocrinol Diabetes2000，108，1： | 1 |
| 20 | Lesion-induced network plasticity in remote brain areas显示文摘 | Witte OW Buchkremer-Ratzmann I Schiene K | 1997 | Trends Neurosci1997，20，： | 1 |
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