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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Surgical cure for early rectal carcinomas (T1)显示文摘 | Günther Winde M.D. Hubert Nottberg M.D. Ralph Keller M.D. Kurt W. Schmid M.D. Hermann Bünte M.D | 1996 | Diseases of the Colon & Rectum1996，，9： | 2 |
| 3 | Comparison of the protective efficacy of recombinant pseudorabies viruses against pseudorabies and classical swine fever in pigs; influence of different promoters on gene expression and on protection显示文摘 | Hoott van Iddekinge B J L de Wind N Wensvoort G | 1996 | Vaccine1996，14，： | 1 |
| 4 | Rapid and automatic image registration algorithm with subpixel accuracy显示文摘 | Althof RJ Wind M G J Dobbins J T | 1997 | IEEE Transactions on Medical Imaging1997，16，3： | 1 |
| 5 | Contribution of single genes within the unique short region of Aujeszky's disease virus (suid herpesvirus type 1) to virulence, pathogenesis and immunogenicity显示文摘 | Kimman T G de Wind N Oei-Lie N | 1992 | J Gen Virol1992，73，2： | 1 |
| 6 | Comparison of the protective efficacy of recombinant pseudorabies viruses against pseudorabies and classical swine in pigs: influence of different promoters on gene expression and on protection显示文摘 | Iddekigene B J De Wind N Wensvoort G | 1996 | Vaccine1996，14，1： | 1 |
| 7 | Limitations of the Mini- Mental State Examination in diagnosing dementia in general prac- tice 显示文摘 | Wind AW Schellevis FG Van Staveren G | 1997 | Int J Geriatr Psychiatry1997，12，1： | 1 |
| 8 | Design and application of decision support systems for integrated water management:lessons to be learnt显示文摘 | de Kok J L Wind H G | 2003 | Physics and Chemistry of the Earth2003，28，： | 1 |
| 9 | A Rapid and Automatic Image Registration Algorithm with Subpixel Accuracy显示文摘 | Althof R J Wind M G J Dobbins J T | 1997 | IEEE Transactions on Medical Imaging1997，，16： | 1 |
| 10 | Overcoming environmental dose rate changes in luminescence dating of waterlain deposits 显示文摘 | Li B Li S H Winde A G | 2008 | Geochronometria2008，30，： | 1 |
| 11 | Complete reversion and prevention of rectal adenomas in colectomized patients with familial adenomatous polyposis by rectal low-dose sulindac maintenance treatment 显示文摘 | Winde G Schmid KW Schlegel W | 1995 | Dis Colon Rectum1995，38，： | 1 |
| 12 | Dcr DASH - Fragcbog- cn- Ein ncucs Instrumentzur显示文摘 | Cemann G Wind G Harth A | 1999 | Beurteilung von Be- hand- lungerge bniss an derobere Extremit Hand- chirmikroc hirplastchir1999，31，： | 1 |
| 13 | Inactivation of glycoprotein gE and Thymidine kinase or the US3-encodded protein kinase synergistically decreasea in vivo replication of pseudorabies virus and the induction of protective immunity显示文摘 | KIMMAN T G WIND N BRUIN T | 1994 | Virology1994，205，： | 1 |
| 14 | Surgical cure for early rectal carcinomas (T1)显示文摘 | Winde G Nottberg H Keller R | | 0，，09： | 1 |
| 15 | Contri- bution of single genes within the unique short region of Au- jeszky' s disease virus ( suid herpesvirus type 1 ) to viru- lence, pathogenesis and immunogenicity 显示文摘 | KIMMAN T G DE WIND N OEI-LIE N | 1992 | J Gen Virol1992，73，2： | 1 |
| 16 | The DASH (Disability of Arm- Shoul-der-Hand)Questionnairea new instrument for evaluating upper extremity treatment outcome 显示文摘 | German G Wind G Harth A | 1999 | Handchir Mikrochir Plast Chir1999，31，3： | 1 |
| 17 | Limitations of the mini-mental state examination in diagnosing dementia in general practice 显示文摘 | Wind AW Schellevis FG Van Staveren G | 1997 | Int J Geriatr Psychiatry1997，12，： | 1 |
| 18 | The DASH(Disability of Arm-Shoulder-Hand) Questionnaire-a new instrument for evaluating upper extremitytreatment outcome显示文摘 | Germann G Wind G Harth A | 1999 | Handchir Mikrochir Plast Chir1999，31，3： | 1 |
| 19 | Morgagni hernia:a rare form of diaphragmatic hernia显示文摘 | Blum M Pelster F er al | 1988 | Zentralbl Chir1988，113，12： | 1 |
| 20 | Contribution of single genes within the unique short region of Aujeszky's disease virus(suid herpesvirus type 1) to virulence,pathogenesis and immunogenicity显示文摘 | KIMMAN T G DE WIND N OEI-LIE N | 1992 | J Gen Virol1992，73，2： | 1 |
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