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| 1 | Safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in hepatitis C virus/human immunodeficiency virus co-infected patients显示文摘AIM To evaluate the safety and efficacy of ledipasvir/sofosbuvir on hepatitis C eradication in patients with hepatitis C virus(HCV)/human immunodeficiency virus(HIV) co-infection in an urban HIV clinic.METHODS A retrospective cohort study of 40 subjects co-infected with HIV-1 and HCV treated with the fixed-dose combination of ledipasvir and sofosbuvir for 12 wk from 2014 to 2016.All patients included were receiving antiretroviral therapy(ART) with HIV RNA values of 100 copies/m L or fewer regardless of baseline HCV RNA level.The primary end point was a sustained virologic response of HCV at 12 wk(SVR12) after the end of therapy.RESULTS Of the 40 patients enrolled,55% were black,22.5% had been previously treated for HCV,and 25% hadcirrhosis.The patients were on a wide range of ART.Overall,39 patients(97.5%) had a SVR 12 after the end of therapy,including rates of 97.1% in patients with HCV genotype 1 a and 100% in those with HCV genotype 1 b.One patient with HCV genotype 3 a was included and achieved SVR12.Rates of SVR12 were similar regardless of previous treatment or the presence of compensated cirrhosis.Only 1 patient experienced relapse at week 12 following treatment and deep sequencing didn't reveal any resistance associated mutation in the NS5A or NS5B region.Interestingly,7(17.5%) patients who were adherent to ART experienced HIV viral breakthrough which resolved after continuing the same ART regimen.Two(5%) patients experienced HIV-1 virologic rebound due to noncompliance with HIV therapy,which resolved after resuming the same ART regimen.No severe adverse events were observed and no patient discontinued treatment because of adverse events.The most common adverse events included headache(12.5%),fatigue(10%),and diarrhea(2.5%).CONCLUSION This retrospective study demonstrated the high rates of SVR12 of ledipasvir/sofosbuvir on HCV eradication in patients co-infected with HCV and HIV,regardless of HCV baseline levels,HCV treatment history or cirrhosis condition.The oral combination of ledipasvir/sofosbuvir represents a safe and well tolerated HCV treatment option that does not require modification for many of the common HIV ART.Occasional HIV virologic rebound occurred but later resolved without the need to change ART. | Xiaoping He Lynne Hopkins George Everett Willie M Carter Cynthia SchroppDyce Khalid Abusaada Vincent Hsu | 2017 | World Journal of Hepatology2017，9，30： | 2 |
| 2 | Diversity of yO T-cell antigens显示文摘 | Willi K Born M Kemal Aydintug Rebecca L O'Brien | 2013 | Cellular & Molecular Immunology2013，10，1： | 2 |
| 3 | HPV E6/E7 mRNA原位杂交诊断宫颈低级别鳞状上皮内病变显示文摘宫颈低级别鳞状上皮内病变(LSIL)[亦称宫颈上皮内瘤变,1级(CIN1)]可带来相当大的诊断挑战,并且与观察者之间重复性较差和过诊断有关。此外,一些辅助性检测项目,如p16免疫组化检查在解析LSIL与正常/反应性鳞状上皮病变的差异作用不大。人类乳头状瘤病毒(HPV)RNA原位杂交(ISH)检测在LSIL的诊断中可能是一种较好的辅助诊断方法,但目前这方面尚没有较大宗病例的研究。 | 解建军 张仁亚 Mills A M Coppock J D Willis B C | 2018 | 临床与实验病理学杂志2018，34，11： | 2 |
| 4 | Human enamel thickness and ENAM polymorphism显示文摘The tooth enamel development gene, enamelin(ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism(SNP) C14625T(rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency. Digital radiographs and DNA samples from 244 teeth in 133 subjects were analysed, and enamel thickness was assessed in relation to SNP status,controlling for age, sex, tooth number and crown length. Crown length was found to increase with molar number, and females were found to have thicker enamel. Teeth with larger crowns also had thicker enamel, and older subjects had thinner enamel.Linear regression and generalized estimating equations were used to investigate the relationship between enamel thickness of the mandibular molars and ENAM SNP status; enamel in subjects with the derived allele was significantly thinner(P = 0.040)when the results were controlled for sex, age, tooth number and crown length. The derived allele demonstrated a recessive effect on the phenotype. The data indicate that thinner dental enamel is associated with the derived ENAM genotype. This is the first direct evidence of a dental gene implicated in human adaptive evolution as having a phenotypic effect on an oral structure. | Diane M Daubert Joanna L Kelley Yuriy G Udod Carolina Habor Chris G Kleist Ilona K Furman Igor N Tikonov Willie J Swanson Frank A Roberts | 2016 | International Journal of Oral Science2016，8，2： | 2 |
| 5 | Determination of total mercury in biological samples using flow injection CVAAS following tissue solubilization in formic acid显示文摘 | Kan M Willie S N Scriver C | 2006 | Talanta2006，68，4： | 1 |
| 6 | Muscle ring finger 1, but not mus- cle ring finger 2, regulates cardiac hypertrophy in vivo显示文摘 | Willis M S Ike C Li L | 2007 | Circ Res2007，100，4： | 1 |
| 7 | Phase Size/Composition Dependence in Irmni~ible Blends: Experimental and Theoretical Considerations显示文摘 | Favis B D Willis J M | 1990 | J Pol~n Sci Part B: Polym Phys1990，28，： | 1 |
| 8 | Induction of epithelial- mesenchymal transition in alveolar epithelial cells by transforming growth factor -β1, potential role in idiopathic pulmonary fibrosis显示文摘 | WILLIS B C LIEBLER J M LUBY- PHELPS K | 2005 | Am J Pathol2005，166，5： | 1 |
| 9 | Deletion of pe38 attenuates AcMNPV genome replication, budded virus production, and virulence in Heliothis virescens显示文摘 | Milks M L Washburn J O Willis L G | 2003 | Virology2003，310，2： | 1 |
| 10 | N02 detection at roomtemperature with copper phthalocyanine thin film devices 显示文摘 | NEWTON M STARKE T WILLIS M | 2000 | SensActuat B: Chem2000，67，3： | 1 |
| 11 | Spatial load forecasting显示文摘 | Willis H L Engel M V Buri M J | 1995 | IEEE Computer Applications in Power1995，8，2： | 1 |
| 12 | Hysteretic characteristics of atrazine adsorption-desorption by a sharkey soil显示文摘 | Ma L Southwick L M Willis G H | 1993 | Weed Science1993，41，4： | 1 |
| 13 | Design and development of a direct injected, glow plug ignition-assisted, natural gas engine 显示文摘 | Willi M L Richards B G | 1995 | Eng Gas Turbines Power1995，117，： | 1 |
| 14 | Measurement and parameterization of albedo variations at Haut Glacier d'Arolla, Switzerland显示文摘 | Brock B W Willis I C Sharp M J | 2000 | 46(155) : 675-6882000，46，155： | 1 |
| 15 | Current approaches to the revegetafion and reclamation of metalliferous mine wastes显示文摘 | Ton:loft G M Baker A J M Willis A J | 2000 | Chem- osphere2000，41，： | 1 |
| 16 | Seasonal changes in the morphology of the subglacial drainage system, Haut Glacier d 'Arolla, Switzerland显示文摘 | Nienow P Sharp M Willis I | 1998 | Earth Surface Processes and LandJbrms1998，23，9： | 1 |
| 17 | Characteristics of mitochondrial isolated from type I and type II b skeletal muscle 显示文摘 | Jackman M R Willis W T | 1996 | Am J Physiol1996，270，： | 1 |
| 18 | Regulation of Tabtoxin Production by the lemA Gene in Pseudomonas syringae显示文摘 | BARTA T M Kinscherf T G Willis D K | 1992 | J Bacteriol1992，174，9： | 1 |
| 19 | Chondroitin sulfate B exerts its inhibitory effect on secondary lymphoid tissue chemokine(SLC)by binding to the C-terminus of SLC显示文摘 | Hirose J Kawashima H Swope Willis M | 2002 | Biochim Biophys Acta2002，1571，3： | 1 |
| 20 | Everyday problem solving in older adults:observational assessment and Cognitive Correlates 显示文摘 | Diehl M Willis S Schaie K | 1995 | Psychol Aging1995，10，： | 1 |
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