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| 1 | Bisphenol A exposure alters release of immune and developmental modulators and expression of estrogen receptors in human fetal lung fibroblasts显示文摘Bisphenol A(BPA) has been shown to exert biological effects through estrogen receptor(ER)-dependent and ER-independent mechanisms. Recent studies suggest that prenatal exposure to BPA may increase the risk of childhood asthma. To investigate the underlying mechanisms in the actions of BPA, human fetal lung fibroblasts(h FLFs) were exposed to varying doses of BPA in culture for 24 hr. Effects of BPA on localization and uptake of BPA,cell viability, release of immune and developmental modulators, cellular localization and expression of ERα, ERβ and G-protein coupled estrogen receptor 30(GPR30), and effects of ERs antagonists on BPA-induced changes in endothelin-1(ET-1) release were examined.BPA at 0.01–100 μmol/L caused no changes in cell viability after 24 hr of exposure. h FLFs expresses all three ERs. BPA had no effects on either cellular distribution or protein expression of ERα, however, at 100 μmol/L(or 23 μmol/L intracellular BPA) increased ERβprotein levels in the cytoplasmic fractions and GPR 30 protein levels in the nuclear fractions.These paralleled with increased release of growth differentiation factor-15, decreased phosphorylation of nuclear factor kappa B p65 at serine 536, and decreased release of ET-1,interleukin-6, and interferon gamma-induced protein 10. ERs antagonists had no effects on BPA-induced decrease in ET-1 release. These data suggest that BPA at 100 μmol/L altered the release of immune and developmental modulators in h FLFs, which may negatively influence fetal lung development, maturation, and susceptibility to environmental stressors, although the role of BPA in childhood asthma remains to be confirmed in in vivo studies. | Laziyan Mahemuti Qixuan Chen Melanie C. Coughlan Min Zhang Maria Florian Ryan J Mailloux Xu-Liang Cao Kylie A. Scoggan William G. Willmore Xiaolei Jin | 2016 | Journal of Environmental Sciences2016，28，10： | 3 |
| 2 | A comparison of magnetoencephalography, MRI, and V-EEG in patients evaluated for epilepsy surgery显示文摘 | Wheless JW Willmore LJ Breier JI | 1999 | Epilepsia1999，40，7： | 2 |
| 3 | The gut:a central organ after surgical stress显示文摘 | Smith RJ Wyer ST | 2000 | Surgery2000，104，5： | 1 |
| 4 | A comparison of magnetoencephalography,MRI,and V-EEG in patients evaluated for epilepsy surgery 显示文摘 | Wheless JW Willmore LJ Breier JI | 1999 | Epilepsia1999，40，： | 1 |
| 5 | Post2 traumaticseizures 显示文摘 | Willmore LJ | 1993 | NeurolClin1993，11，4： | 1 |
| 6 | Regulation of iron pathways in response to hypoxia 显示文摘 | Chepelev N Willmore WG | 2011 | Free Radical Biology & Medicine2011，50，6： | 1 |
| 7 | Recurrent seizures induced by cortical iron injection:a model of posttraumatic epilepsy显示文摘 | Willmore LJ George W Sypert GW | | 0，，04： | 1 |
| 8 | Management of epilepsy in the elderly显示文摘 | WILLMORE LJ | 1996 | Epilepsia1996，37，6： | 1 |
| 9 | Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study显示文摘 | McLean MJ Morrell MJ Willmore LJ | 1999 | Epilepsia1999，40，7： | 1 |
| 10 | Steady-state kinetics of Valproic acid in epileptic patients 显示文摘 | BRUNI J WILDER B J WILLMORE L J | 1978 | Clin Pharmacol Ther1978，24，： | 1 |
| 11 | Safety and tolerability ofgabapentin as adjunctive therapy in a large,multicenter study显示文摘 | McLean RE Morrell MJ Willmore LJ | 1999 | Epilepsia1999，40，7： | 1 |
| 12 | NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699 显示文摘 | Hunter J E Willmore E Irving J A | 2012 | Oncogene2012，31，2： | 1 |
| 13 | Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis显示文摘 | Ueda Y Willmore L J | 2000 | Exp Brain Res2000，133，3： | 1 |
| 14 | Posttraumatic epilepsy:hemorrhage,free radicals and the molecular regulation of glutamate显示文摘 | Willmore LJ Ueda Y | | 0，，04： | 1 |
| 15 | Post-traumatic seizures显示文摘 | Willmore LJ | 1993 | Neurol Clin1993，11，4： | 1 |
| 16 | Molecular regulation of glutamate and GABA transporter proteins by clobazam during epileptogenesis in Fe (+ + +) -induced epileptic rats显示文摘 | Doi T Ueda Y Tokamaru J Willmore LJ | 2005 | Brain Res Mol Brain Res2005，142，2： | 1 |
| 17 | Posttraumatic Epilepsy: What's contusion gotto do with it显示文摘 | Willmore LJ | 2012 | Epilepsy Curr2012，12，3： | 1 |
| 18 | Vigabatrin : 2008 update 显示文摘 | Willmore L J Abelson M B Ben-Menachem E | 2009 | Epilepsia2009，50，2： | 1 |
| 19 | The gut:a central organ after surgical stress显示文摘 | Willmore DW Smith RJ Wyer ST | 2000 | Surgery2000，104，5： | 1 |
| 20 | The novel poly (ADP-Ribose) polymerase inhibitor,AG14361,sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks显示文摘 | Smith LM Willmore E Austin CA | 2005 | Clin Cancer Res2005，11，23： | 1 |
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