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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation显示文摘The scarcity of liver grafts in Asia leads to a significant dropout of patients from liver transplant waiting lists, particularly patients with hepatocellular carcinoma and a low model for end-stage liver disease score. In order to reduce dropping out, different bridging therapies are employed. We report the use of high-intensity focused ultrasound ablation as a bridging therapy for a patient with hepatocellular carcinoma of stage two and an extremely low platelet count (20×10 9 /L). The ablation was successful. Blood tests showed that his liver function was similar before and after the treatment. No adhesion was encountered in the liver transplantation performed six months later. | Tan To Cheung Kenneth SH Chok Regina CL Lo William W Sharr See Ching Chan Ronnie TP Poon Sheung Tat Fan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 3 |
| 3 | The role of ocular pigmentation in protecting against retinal light damage 显示文摘 | Rapp LM Williams TP | 1980 | Vision Res1980，20，： | 1 |
| 4 | Importance of identifying the inconspicuous penis: prevention of circumcision complications显示文摘 | Williams CP Richardson BG Bukowski TP | 2000 | Urology2000，56，1： | 1 |
| 5 | Hypeiparathyroidism in pregnancy :options for localization and surgical therapy显示文摘 | McMullen TP Learoyd DL Williams DC | 2010 | World J Surg2010，34，8： | 1 |
| 6 | Tuberculosis,AIDS,and death among substance abusers on welfare in NewYork City显示文摘 | Friedman LN Williams MT Singh TP | 1996 | N Engl J Med1996，334，13： | 1 |
| 7 | The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration显示文摘 | Wenzel A Reme CE Williams TP | 2001 | J Neurosci2001，21，： | 1 |
| 8 | Locomotor step training with body weight support improves respiratory mo- tor function in individuals with chronic spinal cord injury 显示文摘 | Daniela TP William M Sevda A | 2013 | Respir Physiol Neurobiol2013，189，3： | 1 |
| 9 | Evidence of extrahepatic sites of replication of the hepatitis E virus in a swine model显示文摘 | Williams TP Kasorndorkbua C Halbur PG | | 0，，： | 1 |
| 10 | Management of ameloblastoma:a changing perspective显示文摘 | | 1993 | J Oral Maxillofac Surg1993，51，： | 1 |
| 11 | Mechanisms of immunotherapy in allergic rhinitis显示文摘 | Jayasekera NP Toma TP Williams A | 2007 | Biomed Pharmacother2007，61，1： | 1 |
| 12 | Depressive symptoms and adverse outcomes from hospitalization in older adults: secondary outcomes of a trial of falls prevention education 显示文摘 | Haines TP Williams CM Hill AM | 2014 | Archives of Gerontology and Geriatrics2014，60，1： | 1 |
| 13 | Nature reserve requirements for landscape-dependent ungulates:the case of endangered takin(Budorcas taxicolor)in Southwestern China显示文摘 | Guan TP Wang F William J M | 2015 | Biological Conservation2015，，182： | 1 |
| 14 | Ethanol fixation of sputum sediments for DNA-based detection of Mycobacterium tuberoulosis显示文摘 | Williams DL Gillis TP Dupree WG etal | 1995 | J Clin Microbiol1995，33，6： | 1 |
| 15 | The role of ocular pigmentation in protec- ting against retinal light damage 显示文摘 | Rapp LM Williams TP | 1980 | Vision Res1980，20，12： | 1 |
| 16 | CCR5 genotype and human immunodeficiency virus (HIV)-specific mucosal anti- body in seronegative women at high risk for HIV infection显示文摘 | Williams SB Flanigan TP Artenstein AW | 1999 | J In- fect Dis1999，179，： | 1 |
| 17 | Peritoneal closure or non-closure at cesarean section显示文摘 | Marcello P Michael TP William F | 1991 | Obstet Gynecol1991，77，1： | 1 |
| 18 | Molecular detection of drug resistance in Mycobacterium leprae 显示文摘 | Williams DL Gillis TP | 2004 | Lepr Rev2004，75，2： | 1 |
| 19 | Photoreceptor autophagy: effects of light history on num- ber and opsin content of degradative vacuoles 显示文摘 | REME CE WOLFRUM U IMSAND C HAFEZI F WILLIAMS TP | 1999 | Invest Ophthalmol Vis Sei1999，40，0： | 1 |
| 20 | Evidence of extrahepatic sites of replication of the hepatitis E virus in a swine model显示文摘 | Williams TP Kasomdorkbua C Halbur PG | 2001 | J Clin Microbiol2001，39，9： | 1 |
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