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| 1 | 2型糖尿病患者采用血管紧张素转换酶抑制剂治疗后血清肌酐急性升高及其继续治疗对主要临床结局的影响显示文摘血管紧张素转换酶抑制剂开始治疗后血清肌酐急性升高≥30%时推荐停药。但血清肌酐升高后继续服药或停药对主要临床结局的长期影响仍不明确。在ADVANCE(糖尿病与血管疾病行动:培哚普利-吲达帕胺与达美康缓释片对照评估)试验中,11 140例糖尿病患者在6周活性导入期后随机采用培哚普利-吲达帕胺或安慰剂治疗。 | Ohkuma T Jun M Rodgers A Cooper ME Glasziou P Hamet P Harrap S Mancia G Marre M Neal B Perkovic V Poulter N Williams B Zoungas S Chalmers J Woodward M 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，1： | 6 |
| 2 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 3 | Clinical significance of skin reaction to mito extracts in children with asthma显示文摘 | Simth JM Disney ME William JD | 1996 | BMJ1996，1，： | 2 |
| 4 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 5 | CD8+- T- cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventionl CD4+ T cells显示文摘 | Casciotti L Ely K Williams ME | 2002 | Infect Immune2002，70，2： | 1 |
| 6 | Renal failure resulting from infiltration by inflammatory myofibroblastic tumor responsive to corticosteroid therapy 显示文摘 | Williams ME Longmaid HE Trey G | 1998 | Am J Kidney Dis1998，31，6： | 1 |
| 7 | Experiences of caregivers ofpeople with Parkinson,s disease in Singapore: A qualitative anal-ysis显示文摘 | Tan SB Williams AF Morris ME | 2012 | Journal of Clinical Nursing2012，，21： | 1 |
| 8 | Genetic engineering for pollination control显示文摘 | Williams ME | 1995 | Trends Biotechnol1995，13，： | 1 |
| 9 | Sequence and expression of mRNAs encoding the alphal and alpha2 subunits of a DHP-sensitive calcium channel显示文摘 | ELLIS SB WILLIAMS ME WAYS NR | 1988 | Science1988，21，4873： | 1 |
| 10 | Elevated expression of the interleukin-8 receptors CXCR1 and CXCR2 in peripheral blood cells in obstructive coronary artery disease显示文摘 | Leonard DA Merhige ME Williams BA | 2011 | Coron Artery Dis2011，22，7： | 1 |
| 11 | Diabetic nephropathy:the proteinuria hypothesis显示文摘 | Williams ME | 2005 | Am J Nephrol2005，25，2： | 1 |
| 12 | Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy显示文摘 | Boltonw K Cattran DC Williams ME | 2004 | Am J Nephrol2004，24，1： | 1 |
| 13 | Studies of serumcreactive protein in systemic lupus erythematosus 显示文摘 | Williams RCJR Harmon ME Burligame R | 2005 | J Rheumatol2005，32，3： | 1 |
| 14 | New potential agents in treating diabetic kidney disease:the fourth act显示文摘 | Williams ME | 2006 | Drugs2006，66，18： | 1 |
| 15 | Myositis caused by Pleistophora in a patient with AIDS显示文摘 | Grau A Valls ME Williams JE | 1996 | Med Clin1996，107，20： | 1 |
| 16 | The angiogenic and lymphangiogenic factor VEGF-D exhibits a paracrine mode of action in cancer显示文摘 | Achen MG Williams RA Baldwin ME | 2002 | Growth factors2002，20，2： | 1 |
| 17 | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics显示文摘 | Stacker SA Caesar C Baldwin ME Thornton GE Williams RA Prevo R | 2001 | Nat Med2001，7，2： | 1 |
| 18 | Effects of pyridoxamine in combined phase 2 studies of patients with type I and type 2 diabetes and overt nephropathy显示文摘 | Williams ME Bolton WK Khalifah RG | 2007 | Am J Nephrol2007，27，： | 1 |
| 19 | New potential agents in treating diabetic kidney disease: the fourth act显示文摘 | Williams ME | 2006 | Drugs2006，66，18： | 1 |
| 20 | Predictions of response to pain management treatment:The role of family environment and changes in cognitive processes显示文摘 | Tota-Faucette ME Gill KM Williams FJ | | 0，，： | 1 |
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