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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Do early quadriceps exercis- es affect the outcome of ACL reconstruction? A randomized con- trolled trial显示文摘 | Shaw T Williams MT Chipchase LS | 2005 | Aust J Physiother2005，51，1： | 1 |
| 3 | REMM: the ri- parian ecosystem management model显示文摘 | Lowrance R Airier LS Williams RG | 2000 | Journal of Soil and Water Conservation2000，55，1： | 1 |
| 4 | Performance of the PHQ-9 as a Screening Tool for Depression After Stroke 显示文摘 | Williams LS Brizendine EJ Plue L | 2005 | Stroke2005，36，： | 1 |
| 5 | Regulation of multiple angiogenic pathways by DLIA and Notch in human umbilical vein endothelial cells显示文摘 | Harrington LS Sainson RC Williams CK | 2008 | Microvasc Res2008，75，2： | 1 |
| 6 | Development of a stroke-specific quality of life scale 显示文摘 | Williams LS Weinberger M Harris LE | 1999 | Stroke1999，30，7： | 1 |
| 7 | Ichthyosis, deafness, and Hirschsprung's disease 显示文摘 | Mallory SB Haynie LS Williams ML | 1989 | Pediatr Dermatol1989，6，1： | 1 |
| 8 | Effects of edmission hyperglyce- nian on mortality and costs in acute ischermic stroke显示文摘 | Williams LS Retich J | 2002 | Netrology2002，59，1： | 1 |
| 9 | Effect of atropine and/or physostigmine on cerebral acetylcholine in rats poisoned with Soman显示文摘 | Larrel WH William CH David LS | 1978 | Life Sci1978，22，10： | 1 |
| 10 | Depression and other mental heath diagnoses increase mortality risk after isehemic stroke 显示文摘 | Williams LS chose SS Swindle RW | 2004 | AM J Psychiatry2004，61，6： | 1 |
| 11 | Controlled local delivery of tetracycline with polymer strips in the treatment of periodontitis显示文摘 | Friesen LR Williams KB Krause LS | 2002 | J Periodontol2002，73，1： | 1 |
| 12 | Development of a stroke-specific quality of life scale 显示文摘 | Williams LS | 1999 | Stroke1999，，： | 1 |
| 13 | Depression and other mental health diagnosis increase mortality risk after ischemia stroke显示文摘 | Williams LS Ghose SS Swindle RW | 2004 | Am J Psychiatry2004，161，6： | 1 |
| 14 | Depression and other mental health diagnoses increase mortality risk after ischemic stroke显示文摘 | Williams LS Ghose SS Swindle RW | 2004 | Am J Psychiatry2004，161，6： | 1 |
| 15 | Depression and othermental health diagnoses increase mortality risk after ischemicstroke 显示文摘 | Williams LS Ghose SS Swindle RW | 2004 | Am J Psychiatry2004，161，6： | 1 |
| 16 | Derivation and validation of a clinical system for predicting pneumonia in acute stroke显示文摘 | Chumbler NR Williams LS Wells CK | 2010 | Neuroepidemio2010，34，3： | 1 |
| 17 | Metabolomics of colorectal cancer :past and current analytical platforms 显示文摘 | Williams MD Reeves R Resar LS | 2013 | Anal Bioanal Chem2013，405，15： | 1 |
| 18 | Pediatric Evaluation of the Bispectral Index (BIS) Monitor and Correlation of BIS with End-tidal Sevoflurane Concentration in Infants and Children 显示文摘 | William TD Emily LS David R | 2000 | Anesth Analg2000，90，4： | 1 |
| 19 | Subtypes of ischemic stroke in children and young adults显示文摘 | Garg BP Cohen M | 1997 | Neurology1997，49，6： | 1 |
| 20 | Stroke patients knowledge of stroke:Influence on time to presentation显示文摘 | Bruno A Rouch D | 1997 | Stroke1997，28，： | 1 |
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