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| 1 | MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside显示文摘MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs. | Kenneth KW To Christy WS Tong Mingxia Wu William CS Cho | 2018 | World Journal of Gastroenterology2018，24，27： | 29 |
| 2 | 蛋白质组学与转化医学:用以癌症诊断、预后和疗效预测的分子生物标记物显示文摘“生物医学研究的最新技术进展使鉴定多种分子生物标记物变得更加容易,有助于促进癌症筛查和检测……通过允许医生为患者制定个体化治疗来提高癌症治疗的有效性和安全性。” | William CS CHO 南娟(翻译) 曹志成(校对) | 2011 | 中国肺癌杂志2011，14，8： | 9 |
| 3 | 癌症相关遗传变异的新进展及其在诊断研发中的意义显示文摘"了解更多癌症相关的遗传变异可能有助于癌症的预防和早期诊断,以及为癌症个体化诊断和治疗方案开辟新途径。" | 南娟(翻译) 曹志成(校对) William CS CHO | 2011 | 中国肺癌杂志2011，14，1： | 5 |
| 4 | Screw dislocation structure and mobility in body centered cubic Fe predicted by a Gaussian Approximation Potential显示文摘The plastic flow behavior of bcc transition metals up to moderate temperatures is dominated by the thermally activated glide of screw dislocations,which in turn is determined by the atomic-scale screw dislocation core structure and the associated kink-pair nucleation mechanism for glide.Modeling complex plasticity phenomena requires the simulation of many atoms and interacting dislocations and defects.These sizes are beyond the scope of first-principles methods and thus require empirical interatomic potentials.Especially for the technological important case of bcc Fe,existing empirical interatomic potentials yield spurious behavior.Here,the structure and motion of the screw dislocations in Fe are studied using a new Gaussian Approximation Potential(GAP)for bcc Fe,which has been shown to reproduce the potential energy surface predicted by density-functional theory(DFT)and many associated properties.The Fe GAP predicts a compact,non-degenerate core structure,a single-hump Peierls potential,and glide on{110},consistent with DFT results.The thermally activated motion at finite temperatures occurs by the expected kink-pair nucleation and propagation mechanism.The stress-dependent enthalpy barrier for screw motion,computed using the nudgedelastic-band method,follows closely a form predicted by standard theories with a zero-stress barrier of~1 eV,close to the experimental value of 0.84 eV,and a Peierls stress of~2 GPa consistent with DFT predictions of the Peierls potential. | Francesco Maresca Daniele Dragoni Gábor Csányi Nicola Marzari William A.Curtin | 2018 | npj Computational Materials2018，，1： | 5 |
| 5 | A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension显示文摘 | King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary Tse | 2017 | Journal of Geriatric Cardiology2017，14，12： | 5 |
| 6 | Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling显示文摘AIM: To develop a prognostic gene set that can predict patient overall survival status based on the whole genome expression analysis. METHODS: Using Illumina HumanWG-6 BeadChip followed by semi-supervised analysis, we analyzed the expression of 47 296 transcripts in two batches of gastric cancer patients who underwent surgical resection. Thirty-nine samples in the first batch were used as the training set to discover candidate markers correlated to overall survival, and thirty-three samples in the second batch were used for validation. RESULTS: A panel of ten genes were identified as prognostic marker in the first batch samples and classified patients into a lowand a high-risk group with significantly different survival times (P = 0.000047). This prognostic marker was then verified in an independent validation sample batch (P = 0.0009). By comparing with the traditional Tumor-node-metastasis (TNM) staging system, this ten-gene prognostic marker showed consistent prognosis results. It was the only independent prognostic value by multivariate Cox regression analysis (P = 0.007). Interestingly, six of these ten genes are ribosomal proteins, suggesting a possible association between the deregulation of ribosome related gene expression and the poor prognosis. CONCLUSION: A ten-gene marker correlated with overall prognosis, including 6 ribosomal proteins, was identified and verified, which may complement the predictive value of TNM staging system. | Yue-Zheng Zhang Lian-Hai Zhang Yang Gao Chao-Hua Li Shu-Qinjia Ni Liu Feng Cheng De-Yun Niu William CS Cho Jia-Fu Ji Chang-Qing Zeng | 2011 | World Journal of Gastroenterology2011，17，13： | 5 |
| 7 | miRNAs在肺癌中的作用显示文摘"这些miRNAs在血清中的高表达是非小细胞肺癌的血液生物标记物……"
肺癌居全球癌症死亡原因的首位,但迄今尚无有效针对这一致命疾患的诊断和预测性生物标记物。新证据表明,miRNAs具有以细胞周期依赖性方式调节转录及翻译的潜能,这为我们在分子水平深入理解癌症开拓了新视野。 | William CS CHO 南娟(翻译) 丁燕(翻译) 曹志成(校对) | 2009 | 中国肺癌杂志2009，12，12： | 4 |
| 8 | 癌症研究进展:第100届AACR年会见闻显示文摘本文将综述2009年美国癌症研究学会(AACR)第100届年会的主要报告,并讨论各项科研成果,以及它们对临床实践和在研临床试验的影响。在这些报告中,靶向治疗的预测性生物标记物的相关报道让适当患者选择合适药物变得可行。通过对体细胞基因拷贝数改变、基因组重排及序列突变进行分析,癌基因组的研究结果在深入揭示多种癌症的发病机制中显示了重要作用。有报告再次证实癌干细胞在治疗性抵抗、促血管生成和转移中起重要作用。有报告从不同角度对各种癌症类型中癌干细胞生物学的认识作了介绍。有报告对小分子RNA(microRNA)改变的最新研究成果进行了概述。除癌细胞研究外,研究人员已开始观察肿瘤细胞与其周围环境的信息交流。有报告介绍了肿瘤微环境与炎症方面的最新成果。有报告陈述了纳米技术和生物标记物发现的最新进展。此外,大会上有些临床试验结果支持应用新的靶向治疗方法,而有些研究者则致力于采用现有药物和方法进行癌症预防。本文将对2009年AACR年会的上述及其它重要报告进行讨论,旨在为读者提供全球最重要癌症研究会议上的癌症研究最新进展。 | William CS Cho 南娟(翻译) 丁燕(翻译) 曹志成(校对) | 2009 | 中国肺癌杂志2009，12，11： | 4 |
| 9 | MiRNA作为肺癌分子诊断工具的前景与挑战显示文摘“在过去的十年里,miRNA已成为调节基因表达的关键分子之一。它几乎涉及肺癌癌变的每一个进程,包括肿瘤进展、血管新生、侵袭和转移。” | William CS CHO 丁燕(翻译) 南娟(翻译) 曹志成(校对) | 2012 | 中国肺癌杂志2012，15，2： | 3 |
| 10 | Host cyclooxygenase-2 modulates carcinoma growth显示文摘 | Williams CS Tsujii M Reese J | | 0，，： | 2 |
| 11 | Host cyclooxygenase-2 modulates carcinoma growth显示文摘 | Tsujii M Reese J | 2000 | J Clin Invest2000，105，： | 1 |
| 12 | A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro显示文摘 | Inoue I Nakajima T Williams CS | 1997 | J Clin Invest1997，99，： | 1 |
| 13 | Failure to replicate a genetic association may provide important clues about genetic architecture显示文摘 | Greene CS Penrod NM Williams SM | 2009 | PLoS One2009，4，： | 1 |
| 14 | Prostaglandin endoperoxide synthase: why two isoforms? 显示文摘 | Williams Cs Dubois RN | 1996 | Am J Physiol1996，270，31： | 1 |
| 15 | Elevated cyclooxygenase-2 levels in Min mouse adenomas显示文摘 | Williams CS Luongo C Radhika A | 1996 | Gastroenterology1996，111，： | 1 |
| 16 | Risk factors forheart failure in the elderly : a prospective community-basedstudy显示文摘 | Chen YT Vaccarino V Williams CS | 1999 | Am J Med1999，106，6： | 1 |
| 17 | Treatment of myelopathyin Sjogren syndrome with a combination of prednisone andcyclophosphamide显示文摘 | Williams CS Butler E Roman GC | 2001 | Arch Neurol2001，58，5： | 1 |
| 18 | Aspirin use and potential mechanisms for colorectal cancer prevention显示文摘 | Williams CS Smalley W DuBois RN | 1997 | J Clin Invest1997，100，6： | 1 |
| 19 | Host cyclooxygenase-2 modulates carcinoma growth显示文摘 | Williams CS Tsujii M Reese J | 2000 | J Clin Invest2000，105，11： | 1 |
| 20 | Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway 显示文摘 | Sheng H Williams CS Shao J | 1998 | J Biol Chem1998，273，22： | 1 |
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