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7篇 您的检索式：作者名="Wilbert P"

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		题名	作者	年代	出处	被引量
	1	Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas显示文摘AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds.METHODS:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal cancer.Biopsies were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)reasons.After storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as substrates.RESULTS:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by histopathology.Enzyme activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the UGT.Analysis of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer patients.The means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for carcinomas.CONCLUSION:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range.	Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters	2013	World Journal of Gastroenterology2013，19，36：	3
	2	Monte Carlo calculation of electron transport through hop and flu spacers in HOPFED 显示文摘	Zhong X Wilbert P Engelsen D	2004	J Soc Inf Display2004，12，：	1
	3	Genetic improvement of tree species for remediation of hazardous wastes显示文摘	Stomp A M Han K H Wilbert S Gordon M P		0，，：	1
	4	Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC 显示文摘	Ebert O Wilbert D Buttgereit P	2004	Genet Vaccines Ther2004，2，：	1
	5	Quantification of jasmonic acid, methyl jasmonate, and salicylic acid in plants by capillary liquid chromatography electrospray tandem mass spectrometry显示文摘	Sibylle M Wilbert Lowell H Ericsson Milton P Gordon	1998	Analytical Biochemistry1998，257，2：	1
	6	Effect of oltipraz, atocopherol, β-carotene and phenethylisothiocyanate on rat oesophageal, gastric, colonic and hepatic glutathione, glutathione S-transferase and peroxidase显示文摘	STHER M M WILBERT H M P JAN B M	1996	Carcinogenesis1996，17，7：	1
	7	Double contrast-enhanced ultrasonography evaluation of preoperative Lauren classification of advanced gastric显示文摘	Huang P Li S Wilbert S	2011	Arch Med Sci2011，7，2：	1

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