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| 1 | Physical activity, obesity and gastroesophageal reflux disease in the general population显示文摘AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) 'high' (several times/week); (2) 'intermediate' (approximately once weekly); and (3) 'low' (1-3 times/mo or less). Analyses were stratified for participants with 'normal weight' (BMI < 25 kg/m 2 ), 'overweight' (BMI 25 to ≤ 30 kg/m 2 ) and 'obese' (BMI > 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low frequency of physical activity. However, after adjustment for potential confounding factors, neither intermediate (OR: 1.30, 95% CI: 0.75-2.26) nor high (OR: 0.99, 95% CI: 0.62-1.60) frequency of physical activity was followed by decreased risk of GERD. Sleeping problems and high comorbidity were identified as potential confounders. Among the 1859 overweight participants, crude point estimates indicated no increased or decreased risk of GERD among individuals with intermediate or high frequency of physical activity, compared to low frequency. After adjustment for confounding, neither intermediate (OR: 0.75, 95% CI: 0.46-1.22) nor high frequency of physical activity were followed by increased or decreased risk of GERD compared to low frequency among nonobese participants. Sleeping problems and high comorbidity were identified as potential confounders for overweight participants. In obese individuals, crude ORs were similar to the adjusted ORs and no particular confounding factors were identified. Intermediate frequency of physical activity was associated with a decreased occurrence of GERD compared to low frequency of physical activity (adjusted OR: 0.41, 95% CI: 0.22-0.77). CONCLUSION: Intermediate frequency of physical activity might decrease the risk of GERD among obese individuals, while no influence of physical activity on GERD was found in non-obese people. | Therese Djrv Anna Wikman Helena Nordenstedt Asif Johar Jesper Lagergren Pernilla Lagergren | 2012 | World Journal of Gastroenterology2012，18，28： | 8 |
| 2 | Allelic imbalances in human bladder cancer genome-wide detection with high-density single-nucleitide polymorphism arrays 显示文摘 | Primdala H Wikman FP von der Maase H | 2002 | J Natl Cancer Inst2002，94，3： | 1 |
| 3 | Achieving directed immunostimulating complexes incorporation 显示文摘 | Wikman M Friedman M Pinitkiatisakul S | 2006 | Expert Rev Vaccines2006，5，： | 1 |
| 4 | Metabolism of bilirubin by human cytochrome P450 2A6 显示文摘 | Abu-Bakar A Arthur DM Wikman AS | 2012 | Toxicol Appl Pharmacol2012，261，1： | 1 |
| 5 | Allelic imbalances in human bladder cancer: genome-wide detection with highdensity single-nueleotide polymorphism arrays 显示文摘 | Primdahl H Wikman FP vonder Maase H | 2002 | J Natl Cancer Inst2002，94，3： | 1 |
| 6 | Fetal hemolytic anemia and intrauterine death caused by anti-M immunization显示文摘 | Wikman A Edner A Gryfelt G | 2007 | Transfusion2007，47，5： | 1 |
| 7 | PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis显示文摘 | Wikman H Pantel K Haigis MC | 2014 | Nature cell biology2014，16，10： | 1 |
| 8 | In vitro exposure of human lymphocytes to triehothecenes: individual variation in sensitivity and effects of combined exposure on lymphocyte function 显示文摘 | Thuvander A Wikman C Gadhasson I | 1999 | Food and Chemical Toxicology1999，37，6： | 1 |
| 9 | Selection and characterization of HER2/neu-binding affibody ligands显示文摘 | Wikman M Steffen A C Gunneriusson E | 2004 | Protein Eng Des Sel2004，17，5： | 1 |
| 10 | Increased expression of interleukin 1 alpha and MHC class Ⅰ in muscle tissue of patients with chronic,inactive polymyositis and dermatomyositis显示文摘 | Nyberg P Wikman AL Nennesmo I | | 0，，04： | 1 |
| 11 | Glutathione-S-transfer ase M1, M3, TI and P1 polymorphisms and susceptibility to non-small-cell lung cancer subtypes and hamartomas显示文摘 | Risch A Wikman H Thiel S | 2001 | Phar- macogenetics2001，11，9： | 1 |
| 12 | Rosenmot ( Rhudiola rosea) : traditional use, chemical composition, pharmacology and clinical efficacy显示文摘 | Panossian A Wikman G Sarris J | 2010 | Phytomedieine2010，17，7： | 1 |
| 13 | Modulation of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1, GSTT1, NAT1 and NAT2 显示文摘 | Godschalk RW Dallinga JW Wikman H | 2001 | Pharmacogenetics2001，11，5： | 1 |
| 14 | Caveolins as tumor markers in lung cancer detected by combined use of cDNA and tissue microarrays显示文摘 | Wikman H Seppanen J K Sarhadi V K | 2004 | J Pathol2004，203，1： | 1 |
| 15 | Increased expression of interleukin 1 alpha and MHC class Ⅰ in muscle tissue of patients with chronic,inactive polymyosiris and dermatomyositis显示文摘 | Nyberg P Wikman AL Nennesmo I | 2000 | J Rheumatol2000，27，4： | 1 |
| 16 | A double- blind, placebo-controlled pilot study of the stimulating and adaptogenic effeet of hodiola rosea SHR-5 extract on the fa- tigue of students caused by stress duriug an examination period with a repeated lnw-dose regimen显示文摘 | Spasov AA Wikman G Mandrikov VB | 2000 | Phytomcdicine2000，7，2： | 1 |
| 17 | Rosenroot(Rhodioia rosea):traditional use,chemical composition,pharmacology and clinicalefficacy显示文摘 | Panossian A Wikman G Sarris J | 2010 | Phytomedicine2010，17，7： | 1 |
| 18 | Type-D personality, self-effi- cacy, and medication adherence following an acute coronary syndrome 显示文摘 | Molloy GJ Randall G Wikman A | 2012 | Psychosom Med2012，74，1： | 1 |
| 19 | Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy显示文摘 | PANOSSIAN A WIKMAN G SARRIS J | 2010 | Phytomedicine2010，17，： | 1 |
| 20 | In creased expression of high mobility group A pro teins in lung cancer 显示文摘 | Sarhadi VK Wikman H Salmenkivi K | 2006 | J Pathol2006，209，2： | 1 |
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