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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Prestressed fiber-reinforced polymer laminates for strengthening structures 显示文摘 | EI-Hacha R Wight R G Green M F | 2001 | Prog Struct Engng Master2001，，3： | 1 |
| 3 | Prestressed FRP sheets for poststrengthening reinforced concrete beams 显示文摘 | Wight R G Green M F Erki M A | 2001 | Journal of Composites for Construction2001，5，4： | 1 |
| 4 | Prestressed FRP sheets for poststrengthening reinforced concrete beams 显示文摘 | Wight R G Green M F Erki M A | 2001 | Journal of Composites for Construction2001，5，4： | 1 |
| 5 | Prestressed and nonprestressed CFRP sheet strengthening: damaged continu- ous reinforced concrete beams 显示文摘 | Wight R G El-Hacha R Erki M A | 2003 | International Journal of Materials and Product Technology2003，19，12： | 1 |
| 6 | Prestressed FRP Sheets for Post Strengthening Reinforced Concrete Beams显示文摘 | Wight R G Green M F Erki M A | 2001 | Journal of Composites for Construction2001，5，4： | 1 |
| 7 | Prestressed FRP Sheets for Poststrengthening Reinforced Concrete Beams 显示文摘 | WIGHT R G GREEN M F | 2001 | Journal of Composites for Construction2001，，： | 1 |
| 8 | Prestressed FRP Sheets for Poststrengthening Reinforced Concrete Beams显示文摘 | Wight R G Green M F Erki M A | 2001 | Journal of Composites for Construction2001，5，4： | 1 |
| 9 | Prestressed and non-prestressed CFRP sheet strengthening:damaged continuous reinforced concrete beams显示文摘 | Wight R G El-Hacha R Erki M A | 2003 | International Journal of Materials & Product Technology2003，19，12： | 1 |
| 10 | The Groningen valve voice prosthesis in Sheffield: a 4-year review 显示文摘 | Parker A J O'Leary I K Wight R G | 1992 | J Lar- yngol Otol1992，，： | 1 |
| 11 | Thermal decomposition of solid RDX begins with nitrogen-nitrogen bond scission显示文摘 | Wight C A Botcher T R | | 0，，21： | 1 |
| 12 | Prestressed CFRP sheets for strengthening concrete slabs in fatigue 显示文摘 | Wight R G Erki M A | 2003 | Advances in Structural Engineering2003，6，3： | 1 |
| 13 | Wide beam - column connections under earthquake - type loading显示文摘 | Wight J K | 1994 | Earthquake Spectra1994，10，4： | 1 |
| 14 | Transient thin film laser pyrolysis of RDX显示文摘 | Botcher T R Wight C A | | 0，，36： | 1 |
| 15 | Prestressed FRP Sheets for Post-strengthening Reinforced Concrete Beams 显示文摘 | WIGHT R G GREEN M F ERKI M A | 2001 | Journal of Composites for Construction2001，5，4： | 1 |
| 16 | Prestressed carbon fiber reinforced polymer sheets for strengthening concrete beams at room and low temperatures 显示文摘 | E1-Hacha R Wight R G Green M F | 2004 | Journal of Com- posites for Construction2004，8，1： | 1 |
| 17 | Innovative system for prestressing fiber-reinforced polymer sheets显示文摘 | Raafat EI-Hacha R Gordon Wight and Mark F Green | 2003 | ACI Structural Journal2003，100，3： | 1 |
| 18 | An Office - based Instru- ment for Exercise Counseling and Prescription in Primary Care - The Step Test Exercise Prescription (STEP) 显示文摘 | PET B_ELLA R J WIGHT D | 2000 | Archives Family Med2000，9，4： | 1 |
| 19 | Prestressed FRP Sheets for Post Strengthening Reinforced Concrete Beams 显示文摘 | Wight R G Green M F | 2001 | Journal of Composites for Construction2001，，11： | 1 |
| 20 | Effect of transverse beams and slab on behavior of reinforced concrete beam-to-column connections 显示文摘 | Ehsani M R Wight J K | 1985 | ACI Journal1985，，： | 1 |
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