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| 1 | Transcriptional Regulation of the Ambient Temperature Response by H2A.Z Nucleosomes and HSF1 Transcription Factors in Arabidopsis显示文摘 | Sandra Cortijo Varodom Charoensawan Anna Brestovitsky Ruth Buning Charles Ravarani Daniela Rhodes John van Noort Katja E. Jaeger Philip A. Wigge | 2017 | Molecular Plant2017，10，10： | 15 |
| 2 | 鞘内注射巴氯芬治疗卒中后痉挛性肌张力增高的专家共识指南显示文摘卒中后痉挛性肌张力增高可导致畸形、不适和运动功能缺损加重,鞘内注射巴氯芬(ITB)已经被越来越多地用于这种并发症的处理。由于它在卒中中的应用不像其他适应证一样得到肯定,因此ITB治疗尚未经过严格的研究。指导临床医生在这类患者中进行ITB治疗的证据非常有限。本文旨在对有关这一主题的现有科学文献和一些专家观点进行评价,同时阐述这些专家针对可能影响卒中人群的常见临床问题治疗决策的推荐意见。 | Gerard E. Francisco Smart A. Yablon Mya C. Schiess Laura Wiggs Steven Cavalier Samuel Grissom 李振光(译) 孙新虎(译) 迟相林(译) 蒋东晓(译) 丛艳斌(译) | 2008 | 国际脑血管病杂志2008，16，3： | 4 |
| 3 | Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease显示文摘The search for biomarkers that characterize specific aspects of inflammatory bowel disease(IBD), has received substantial interest in the past years and is moving forward rapidly with the help of modern technologies. Nevertheless, there is a direct demand to identify adequate biomarkers for predicting and evaluating therapeutic response to different therapies. In this subset, pharmacogenetics deserves more attention as part of the endeavor to provide personalized medicine. The ultimate goal in this area is the adjustment of medication for a patient's specific genetic background and thereby to improve drug efficacy and safety rates. The aim of the following review is to utilize the latest knowledge on immunopathogenesis of IBD and update the findings on the field of Immunology and Genetics, to evaluate the response to the different therapies. In the present article, more than 400 publications were reviewed but finally 287 included based on design, reproducibility(or expectancy to be reproducible and translationable into humans) or already measured in humans. A few testshave shown clinical applicability. Other, i.e., genetic associations for the different therapies in IBD have not yet shown consistent or robust results. In the close future it is anticipated that this, cellular and genetic material, as well as the determination of biomarkers will be implemented in an integrated molecular diagnostic and prognostic approach to manage IBD patients. | Emilio G Quetglas Zlatan Mujagic Simone Wigge Daniel Keszthelyi Sebastian Wachten Ad Masclee Walter Reinisch | 2015 | World Journal of Gastroenterology2015，21，44： | 3 |
| 4 | Envionmental exposure to lead and childrens intelligence at the age of seven years:The port Pirie Cohort Study显示文摘 | Baghurst PA Mcmichael AJ Wigg NR | 1992 | Nengl J Med1992，275，： | 3 |
| 5 | The role of streamline curvature in sand dune dynamics: evidence from field and wind tunnel measurements显示文摘 | Giles F.S. Wiggs Ian Livingstone Andrew Warren | 1996 | Geomorphology1996，，1： | 2 |
| 6 | Numerical modelling of flow structures over idealized transverse aeolian dunes of varying geometry显示文摘 | Daniel R. Parsons Ian J. Walker Giles F.S. Wiggs | 2003 | Geomorphology2003，，1： | 2 |
| 7 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 8 | Optimisation of hepatocellular carcinoma surveillance in patients with viral hepatitis: a quality improvement study显示文摘 | N. A. Kennedy A. Rodgers R. Altus R. McCormick R. Wundke A. J. Wigg | 2013 | Intern Med J2013，，7： | 1 |
| 9 | Across towns and across times: library service to young people in rural libraries显示文摘 | Wigg R | 1995 | Illonis1995，，： | 1 |
| 10 | The distinction between ju-venile and adult-onset primary open-angle glaucoma显示文摘 | Wiggs JL Damji KF Haines JL | 1996 | Am JHum Genet1996，58，1： | 1 |
| 11 | Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C显示文摘 | Barr CL Wigg K Zai G | 2001 | Mol Psychiatry2001，6，3： | 1 |
| 12 | Dietary supplementation and respiratory muscle performance in patients with COPD 显示文摘 | Knowles JB Fauban M Wiggs B J | 1988 | Chest1988，93，5： | 1 |
| 13 | G72/G30 (DAOA) and juvenile- onset mood disorders显示文摘 | Gomez L Wigg K Feng Y | 2009 | Am J Med Genet B Neuropsychiatr Genet2009，150，7： | 1 |
| 14 | Identification of DNA variants in the SNAP25 gene and linkage study of these polymorphisms and attention deficit hyperactivity disorder显示文摘 | Barr C Feng Y Wigg K | 2000 | Mol Psychiatry2000，5，4： | 1 |
| 15 | The role of small intestinal bacterial overgrowth,intestinal permeability,endotoxaemia,and tumour necrosis factor in the pathogenesis of non-alcoholic steatohepatitis显示文摘 | Wigg AJ Roberts-Thomson IC Dymock RB | 2001 | Gut2001，48，20： | 1 |
| 16 | Small intestinal bacterial overgrowth,intestinal permeability,and non-alcoholic steatohepatitis:Auther's reply显示文摘 | Wigg AJ Cummins AG | 2002 | Gut2002，50，1： | 1 |
| 17 | The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alopha in the pathogenesis of non-alcoholic steatohepatitis 显示文摘 | Wigg AJ Roberts Thomson IC Dymock RB | 2001 | Gut2001，48，2： | 1 |
| 18 | Serotonin 1A receptors,depression, and memory in temporal lobe epilepsy 显示文摘 | Theodore WH Wiggs EA Martinez AR | 2012 | Epilepsia2012，53，1： | 1 |
| 19 | Further evidence from haplotype analysis for linkage of the the dopamine D4 receptor gene and attention-deficit hyperactivity disorder显示文摘 | Barr CL Wigg KG Bloom S | 2000 | Am J Med Genet2000，96，3： | 1 |
| 20 | Desert dune dynamics and evaluation ofshear velocity: an integrated approach显示文摘 | Wiggs G F S | 1993 | GeologicalSociety1993，72，1： | 1 |
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