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| 1 | Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks显示文摘AIM: To study the predictive value of the vegetative- depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon α-2b of chronic hepatitis C (CHC) patients. METHODS: The predictive value of vegetative- depressive symptoms at 4 wk of treatment for the occurrence of a subsequent diagnosis of major depressive disorder (MDD) was studied in CHC patients infected after substance use in a prospective, multi- center treatment trial in Belgium. The presence of vegetative-depressive symptoms was assessed using the Zung Scale before and 4 wk after the start of antiviral treatment. RESULTS: Out of 49 eligible patients, 19 (39%) developed MDD. The area under the ROC curve of the vegetative Zung subscale was 0.73, P = 0.004. The sensitivity at a cut-point of > 15/35 was 95% (95% CI: 74-100). The positive predictive value equalled 44% (95% CI: 29-60). CONCLUSION: In this group of Belgian CHC patients infected after substance use, antiviral treatment caused a considerable risk of depression. Seven vegetativedepressive symptoms of the Zung scale at wk 4 of treatment predicted 95% of all emerging depressions, at a price of 56% false positive test results. | Geert Robaeys Jozef De Bie Marieke C Wichers Liesbeth Bruckers Frederik Nevens Peter Michielsen Marc Van Ranst Frank Buntinx | 2007 | World Journal of Gastroenterology2007，13，43： | 4 |
| 2 | Behavior of a moored ship in unsteady current, wind, and waves显示文摘 | Kat J O Wichers J E W | 1991 | Marine Technology1991，，5： | 2 |
| 3 | Detection of Treponema pallidum in early syphilis by DNA amplification 显示文摘 | Wicher K Noordhoek GT Abbruscato F | 1992 | J Clin Microbiol1992，30，2： | 1 |
| 4 | The role of indoleamine 2,3-dioxygenase (IDO) in the Pathophysiology of interferon-alpha-induced depression显示文摘 | Wichers M C Maes M | 2004 | J Psychiatry Neurosci2004，29，1： | 1 |
| 5 | Identification of persistent infection in experimental syphilis by PCR 显示文摘 | Wicher K Abbmscato F Wicher V | 1998 | Infect Immun1998，66，6： | 1 |
| 6 | Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels显示文摘 | Wicher D Schfer R Bauernfeind R | 2008 | Nature2008，452，7190： | 1 |
| 7 | Cytokine gene expression in skin of suscepibie guinea pig infected with Treponema pallidum显示文摘 | Wicher V Scarozza A M Ramsingh A I | 1998 | Immunology1998，95，2： | 1 |
| 8 | Enteric infection with an obligate intracellular parasite, Encephalitozoon cunicull,in an experimental model显示文摘 | Wicher V Baughn R E Fuentealba I C | 1991 | Infect Immun1991，59，2： | 1 |
| 9 | Diagnosis of schisto- somiasis by reagent strip test for detection of circulating cathodic antigen 显示文摘 | Van Dam GJ Wichers JH Ferreira TM | 2004 | J Clin Mierobiol2004，42，12： | 1 |
| 10 | Cytokines and major depression显示文摘 | Schiepers OJ Wichers MC Maes M | 2005 | Prog Neuropsychopharmacol Biol Psychiatry2005，29，2： | 1 |
| 11 | On the slowly motion of tankers moored to single-point mooring systems显示文摘 | Wichers J E W | 1978 | Journal of Petroleum technology1978，，： | 1 |
| 12 | Cytokines and major depression 显示文摘 | Schiepers O J Wichers M C Maes M | 2005 | Prog Neuropsychopharmacol Biol Psychiatry2005，29，2： | 1 |
| 13 | Unique accumulation of neuropeptides in an insect: FMRFamide-related peptides in the cockroach, Periplaneta americana显示文摘 | Predel R Neupert S Wicher D | 2004 | Eur J Neurosci2004，20，6： | 1 |
| 14 | Agaricus bisporus browning:a review显示文摘 | JOLIVET S ARPIN N WICHERS HJ | 1998 | Mycol Res1998，102，： | 1 |
| 15 | Detection of Treponema pallidum in early syphilis by DNA amplification显示文摘 | Wicher K Noordhoek GT Abbruscato F | 1992 | J Clin Microbiol1992，30，： | 1 |
| 16 | Behavior of a moored ship in unsteady current, wind, and waves显示文摘 | Kat J O Wichers J E W | 1991 | Marine Technology1991，，5： | 1 |
| 17 | Four-and-one-half years' experience in monitoring of reproducibility of an MR spectroscopy system-application of in vitro results to interpretation of in vivo data显示文摘 | Skorupa A Wicher M Banasik T | 2014 | Appl Clin Med Phys2014，15，： | 1 |
| 18 | Novel peptides with tyrosinase inhibitory activity显示文摘 | Schurink Marloes Berkel Willem J H van Wichers Harry J | 2007 | Peptides2007，28，： | 1 |
| 19 | Structure-function relationship of bifunctional scorpion toxin BmBKTxl显示文摘作为在两条大传导力 Ca 2+-activated K + 隧道(放射性元素) 和 duc t 上的小 c 上活跃的首先识别的蝎子毒素 n c e Ca 2+-activated K + 隧道(SK ) , BmBKTx1 被建议了为二个目标有二张分开的功能的脸。调查这个假设,二两倍异种, K21A-Y30A 和 R9A-K11A,和野类型的毒素在 Escherichia 关口 i 被表示。recombinant 毒素为功能的试金在蟑螂放射性元素和老鼠 SK2 隧道上被测试。变异的 K21A-Y30A 在放射性元素上有功能的戏剧的损失,但是在 SK 上保留了它的功能。变异的 R9A-K11A 没在放射性元素或 SK 上失去功能。这些数据支持二个功能脸的假设并且显示 BK 脸在 C 终端 β-sheet 上。 | Suming Wang Lijun Huang Dieter Wicher Chengwu Chi Chenqi Xu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 1 |
| 20 | Evidence for production and functional activity of nitric oxide in seminiferous tubules and blood vessels of the human testis显示文摘 | Muller D Wichers S | 1997 | J Clin Endocrinol Metab1997，82，12： | 1 |
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