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| 1 | Arterial ketone index in assessing liver function and its detoxicative capability after isehemia-reperfusion injury显示文摘 | Caban A Wiaderkiewicz R Kaminski M | 2000 | Acta Biochimpol2000，47，： | 1 |
| 2 | Tobacco smoke-dependent changes in cytochrome P450 1A1,1A2,and 2E1 protein expressions in fetuses,newborns,pregnant rats,and human placenta显示文摘 | Czekaj P Wiaderkiewicz A Florek E Wiaderkiewicz R | 2005 | Arch Toxicol2005，79，1： | 1 |
| 3 | Evaluation of apoptosis in the liver preserved by simple hypothermia using histidine-tryptophan-ketoglutarate and prolactin-modified histidine-tryptophan-ketoglutarate solution显示文摘 | Budzinski G Wiaderkiewicz R Caban A | 2011 | Transplant Proc2011，43，8： | 1 |
| 4 | lnterleukin 17 and RANTES levels in induced sputum of patients with allergic rhinitis after a single nasal allergen challenge 显示文摘 | Semik-Orzech A Barczyk A Wiaderkiewicz | 2009 | Ann Allergy Asthma Immunol2009，103，5： | 1 |
| 5 | Evaluation ofapoptosis in the liver preserved by simple hypothermia using his-tidine-tryptophan-ketoglutarate and prolactin-modified histidine-tryptophan-ketoglutarate solution 显示文摘 | Budzifiski G Wiaderkiewicz R Caban A | 2011 | Transplant Proc2011，43，8： | 1 |
| 6 | Eotaxin,but not IL-8,is increased in upper and lower airways of allergic rhinitis subject after nasal allergen challenge显示文摘 | Semik-Orzech A Barczyk A Wiaderkiewicz R | 2011 | Allergy Asthma Proc2011，32，3： | 1 |
| 7 | Hypo- thalarnic subependymal niche: a novel site of the adult neuro- genesis 显示文摘 | Rojczyk-Golebiewska E Palasz A Wiaderkiewicz R | 2014 | Cell Mol Neurobiol2014，34，5： | 1 |
| 8 | Arterial ketone index in assessing liver function and its detoxicative capability after ischemia-reperfusion injury 显示文摘 | Caban A Wiaderkiewicz R Kaminski M | 2000 | Acta Biochim Pol2000，47，4： | 1 |
| 9 | In- terleukin 17 and RANTES levels in induced sputum of pa- tients with allergic rhinitis after a single nasal allergen challenge显示文摘 | Semik-Orzech A Barczyk A Wiaderkiewicz R | 2009 | Ann Allergy Asthma Immunol2009，103，5： | 1 |
| 10 | Arterial ketone index in assessing liver function and its detoxicative capability after ischemia-reperfusion injury显示文摘 | Caban A Wiaderkiewicz R Kaminski M | 2000 | Acta Biochim Pol2000，47，： | 1 |
| 11 | Interleukin 17 and RANTES levels in induced sputum of patients with allergic rhinitis after a single nasal allergen challenge显示文摘 | Semik-Orzech A Barczyk A Wiaderkiewicz R | 2009 | Ann Allergy Asthma Immunol2009，103，5： | 1 |
| 12 | Arterial ketone index in assessing liver function and its detoxicative capability after ischemia- reperfusion injury显示文摘 | Caban A Wiaderkiewicz R Kamifiski M | 2000 | Acta Biochim Pol2000，47，4： | 1 |
| 13 | Interleukin 17 and RANTES levels in induced sputum of patients with aller- gic rhinitis after a single nasal allergen challenge显示文摘 | Semik-Orzech A Barczyk A Wiaderkiewicz R | 2009 | Ann Allergy Asthma Immunol2009，103，5： | 1 |
| 14 | Mismatch and blunt to protruding end joining by DNA ligases显示文摘 | Ruiz- Carillo A | 1987 | Nucleic Acids Res1987，15，： | 1 |
| 15 | Profiles of interferon-gamma and interleukin-2 in patients after allogeneic hematopoietic stem cell transplantation显示文摘BACKGROUND Allogeneic hematopoietic stem cell transplantation(allo-HSCT)may be related to the occurrence of complications,including graft-versus-host disease(GvHD)and infections.The pathogenesis of acute GvHD is connected with T lymphocytes,which identify alloantigens on host's antigen-presenting cells,activate production of interferon-gamma(IFN-gamma)and interleukin-2(IL-2),and act on the immune effector cells and damage tissues and organs.AIM The aim of the study was to investigate and distinguish serum concentration profiles of IFN-gamma and IL-2 within a 30-d period after allo-HSCT.METHODS We enrolled 62 patients,i.e.,30(48%)male and 32(52%)female subjects[median age 49.5(19-68)years],after allo-HSCT from siblings(n=12)or unrelated donors(n=50)due to acute myeloid leukemia with myeloablative conditioning(n=26;42%)and with non-myeloablative conditioning(n=36;58%).All patients were given standard immunosuppressive therapy with cyclosporin-A and methotrexate and pre-transplant antithymocyte globulin in the unrelated setting.Blood samples were collected pre-transplant before and after(on day-1)the conditioning therapy and on days+2,+4,+6,+10,+20,and+30 after allo-HSCT.Serum levels of IL-2 and IFNgamma were determined using ELISA.RESULTS Patients were divided into four groups depending on the presence of acute GvHD and clinical manifestations of infection.Group I included patients with neither acute GvHD nor infections[n=15(24%)],group II consisted of patients with infections without acute GvHD[n=17(27%)],group III was comprised of patients with acute GvHD without infections[n=9(15%)],and group IV included patients with both acute GvHD and infections[n=21(34%)].IFN-gamma concentrations were higher in Group II than in other groups on days+20(P=0.014)and+30(P=0.008).Post-hoc tests showed lower concentrations of IFN-gamma on day+30 in groups I(P=0.039)and IV(P=0.017)compared to group II.The levels of IL-2 were mostly undetectable.CONCLUSION Serum levels of IFN-gamma following allo-HSCT progressively escalate.High serum levels of IFN-gamma are related to infectious complications rather than acute GvHD.Serum concentrations of IL-2 in most patients are undetectable. | Malwina Rybicka-Ramos Mirosław Markiewicz Aleksandra Suszka-Świtek Ryszard Wiaderkiewicz Sylwia Mizia Monika Dzierżak-Mietła Krzysztof Białas | 2022 | World Journal of Biological Chemistry2022，13，4： | 0 |
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