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| 1 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | Zoogeography of the imported fire ants显示文摘 | Buren W F Allen G E Whitcomb W H | 1974 | New York Entomol Soc1974，82，： | 1 |
| 4 | 显示文摘 | WHITCOMBE M J RODRIGUEZ M E VILLAR P | 1995 | J Am Chem Soc1995，117，27： | 1 |
| 5 | Comparative experiments with a new adaptive controller for robot arms显示文摘 | Whitcomb L L Rizzi A Koditschek D E | 1993 | IEEE Tranactions on Robotics and Automation1993，9，1： | 1 |
| 6 | Prodicting the selectivity of imprinted polymers显示文摘 | Whitcombe M J Martin L vulfson E N | 1998 | Chromatography1998，47，： | 1 |
| 7 | 查看详情显示文摘 | Whitcombe M J Vulfson E N | | 0，，： | 1 |
| 8 | Surface imprinting of cholesterol on submicrometer core-shell emulsion particles 显示文摘 | Perez N Whitcombe M J Vulfson E N | 2001 | Macromolecules2001，34，4： | 1 |
| 9 | lAP Guidelines for the Surgical Management of Acute Pancreatitis显示文摘 | Uhl W Warshaw A Imrie C Bassi C McKay C J Lankisch PG Carter R Di Magno E Banks PA Whitcomb DC | 2002 | Panereatology2002，2，6： | 1 |
| 10 | A new method for the introduction of recognition site functionality into polymers prepared by molecular imprinting: Synthesis and characterization of polymeric receptors for cholesterol 显示文摘 | Whitcombe M J Rodriguez M E Villar P | 1995 | J Am Chem Soc1995，117，27： | 1 |
| 11 | 显示文摘 | WHITCOMBE M J MARTIN L VULFSON E N | 1998 | Chromatographia1998，47，78： | 1 |
| 12 | Molecularly im- printed nanoparticles prepared by core-shell emulsion polymeriza- tion显示文摘 | PEREZ N WHITCOMBE M J VULFSON E N | 2000 | J Appl Polym Sci2000，77，： | 1 |
| 13 | Adv Mater显示文摘 | Whitcombe B M J Vulfson E N | 2001 | 13(7):467-4882001，13，7： | 1 |
| 14 | Molecular Imprinting for the Selective Adsorption of Organosulphur Compounds Present in Fuels显示文摘 | Castro B Whitcombe M J Vulfson E N | 2001 | Anal Chim Acta2001，435，： | 1 |
| 15 | Predicting the selectivity of imprinted polymers显示文摘 | WHITCOMBE M J MARTIN L VULFSO E N | 1998 | Chromatographia1998，47，78： | 1 |
| 16 | Human pancreatic diges- tive enzymes显示文摘 | Whitcomb D C Lowe M E | 2007 | Dig Dis Sci2007，52，1： | 1 |
| 17 | A new method for the introduction of recognition site functionality into polymers prepared by molecular imprinting: synthesis and characterization of polymeric receptors for cholesterol显示文摘 | WHITCOMBE M J RODRIBUEZ M E VILLAR P | 1995 | J Am Chem Soc1995，117，： | 1 |
| 18 | Enzy-matic synthesis of dimeric and trimeric sugar-fatty acid esters显示文摘 | GAO Chun-li WHITCOMBE M J VULFSON E N | 1999 | Enzyme and Microbial Technology1999，25，3： | 1 |
| 19 | Weight loss:a novel and effective treatment for urinary incontinence显示文摘 | Subak L L Whitcomb E Shen H | | 0，，01： | 1 |
| 20 | Surface imprinting of cholesterol on submicrometer core-shell emulsion particles显示文摘 | Perez N Whitcombe M J Vulfson E N | 2001 | Macromolecules2001，34，4： | 1 |
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