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| 1 | Genome and metabolic engineering in non-conventional yeasts:Current advances and applications显示文摘Microbial production of chemicals and proteins from biomass-derived andwaste sugar streams is a rapidly growing area of research and development.While the model yeast Saccharomyces cerevisiae is an excellent host for the conversion of glucose to ethanol,production of other chemicals from alternative substrates often requires extensive strain engineering.To avoid complex and intensive engineering of S.cerevisiae,other yeasts are often selected as hosts for bioprocessing based on their natural capacity to produce a desired product:for example,the efficient production and secretion of proteins,lipids,and primary metabolites that have value as commodity chemicals.Even when using yeasts with beneficial native phenotypes,metabolic engineering to increase yield,titer,and production rate is essential.The non-conventional yeasts Kluyveromyces lactis,K.marxianus,Scheffersomyces stipitis,Yarrowia lipolytica,Hansenula polymorpha and Pichia pastoris have been developed as eukaryotic hosts because of their desirable phenotypes,including thermotolerance,assimilation of diverse carbon sources,and high protein secretion.However,advanced metabolic engineering in these yeasts has been limited.This review outlines the challenges of using non-conventional yeasts for strain and pathway engineering,and discusses the developed solutions to these problems and the resulting applications in industrial biotechnology. | Ann-Kathrin Lobs Cory Schwartz Ian Wheeldon | 2017 | Synthetic and Systems Biotechnology2017，2，3： | 3 |
| 2 | Microalbuminuria Reduction With Valsartan in Patients With Type 2 Diabetes Mellitus: A Blood Pressure–Independent Effect显示文摘 | Giancarlo Viberti Nigel M. Wheeldon | 2002 | Circulation: Journal of the American Heart Association2002，，6： | 2 |
| 3 | Haemodynamic and endocrine effects of type 1 angiotensin Ⅱ receptor blockade in patients with hypoxaemic cor pulmonale 显示文摘 | Cargill RI Wheeldon NM | 1997 | Cardiovasc Res1997，33，1： | 1 |
| 4 | Microalbuminuria re- duction with valsartan in patients with type 2 diabetes mellitus:a blood pressure independent effect显示文摘 | VIBERTI G WHEELDON NM Microalbuminuria Reduction with Valsartan (MARVAL) Study Investigators | 2002 | Circulation2002，106，6： | 1 |
| 5 | Role of local and systemic angiotensin in diabetic renal disease显示文摘 | Anderson S NM Wheeldon J Segura | | 0，，63： | 1 |
| 6 | Transforming the unacceptable donor:outcomes from the adoption of a standardized donor management technique显示文摘 | Wheeldon DR Potter CD Oduro A | 1995 | J Heart Lung Transplant1995，14，4： | 1 |
| 7 | Calorie restriction in obesity: prevention o{ kidney disease in rodents 显示文摘 | Stern JS Gades MD Wheeldon CM | 2001 | J Nutr2001，131，3： | 1 |
| 8 | Finite element model of human cervical spinal column 显示文摘 | Wheeldon J Khouphongsy P Kumaresan S etal | 2000 | Biomed Sci Instrum2000，36，： | 1 |
| 9 | Validation of a finite element model of the young normal lower cervical spine 显示文摘 | Wheeldon JA Stemper BD Yoganandan N | 2008 | Ann Biomed Eng2008，36，： | 1 |
| 10 | Thoracic organ preservation显示文摘 | | 1991 | Perfusion1991，6，3： | 1 |
| 11 | Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale显示文摘 | Kiely DG Cargill RI Wheeldon NM | 1997 | Cardiovasc Res1997，33，1： | 1 |
| 12 | Brain natriuretic peptide: effect on left ventricular filling patterns in healthy subjects显示文摘 | Wheeldon NM Macleod C | 1995 | Clin Sci1995，88，2： | 1 |
| 13 | Oxygen-reducing enzyme cathodes produced from SLAC,a small laccase from Streptomyces coelicolor显示文摘 | Gallaway J Wheeldon I Rincon R | 2008 | Biosens Bioelectron2008，23，8： | 1 |
| 14 | Microalbuminuria reduction wivalsartan in patients with type 2 diabetes mellitus: a bloopressure-independent effect 显示文摘 | Viberti G Wheeldon N M | 2010 | Circulation2010，10，6： | 1 |
| 15 | Intratrachealaerosolization of endotoxin in the rat: a model of the adult respiratory distress syndrome (ARDS)显示文摘 | Wheeldon EB Walker ME Murphy DJ | 1992 | Lab Anim1992，26，1： | 1 |
| 16 | Long term blood pumping:an overview显示文摘 | Wheeldon D | 1995 | Perfusion1995，10，： | 1 |
| 17 | Thalidomide treatment for chronic graft - versus - host disease 显示文摘 | Norfolk DR Wheeldon J | 1991 | Br J Haematol1991，78，2： | 1 |
| 18 | The potential role of spinal cord cyclooxygenase-2 in the development of Freund's complete adjuvant -induced change in hyperalgesia and allodynia显示文摘 | Hay CH Trevethick MA Wheeldon A | 1997 | Neuroscience1997，，78： | 1 |
| 19 | Ex- perimental flexion/extension data corridors for validation of finite element models of the young, normal cervical spine 显示文摘 | WHEELDON J A PINTAR F A KNOWLES S | 2006 | J Biomech2006，39，2： | 1 |
| 20 | Presumed late diffuse lamellar keratitis progressing to interface fluid syndrome 显示文摘 | Wheeldon CE Hadden OB Niederer RL | 2008 | J Cataract Refract Surg2008，34，2： | 1 |
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