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| 1 | O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),emerged in late 2019 and has since caused a pandemic.Although there have been extensive studies worldwide,our understanding of this newly emerged pathogen is far from sufficient.The pathogenesis of the SARS-CoV-2 infection is not fully understood,although a“two-stage”hypothesis was proposed in our previous study. | Wenmin Tian Delin Li Nan Zhang Guijie Bai Kai Yuan Haixia Xiao Feng Gao Yang Chen Catherine C.L.Wong George Fu Gao | 2021 | Cell Research2021，31，10： | 9 |
| 2 | Recent satellite-derived sea ice volume flux through the Fram Strait: 2011–2015显示文摘The Fram Strait(FS) is the primary region of sea ice export from the Arctic Ocean and thus plays an important role in regulating the amount of sea ice and fresh water entering the North Atlantic seas. A 5 a(2011–2015) sea ice thickness record retrieved from Cryo Sat-2 observations is used to derive a sea ice volume flux via the FS. Over this period, a mean winter accumulative volume flux(WAVF) based on sea ice drift data derived from passivemicrowave measurements, which are provided by the National Snow and Ice Data Center(NSIDC) and the Institut Francais de Recherche pour d'Exploitation de la Mer(IFREMER), amounts to 1 029 km^3(NSIDC) and1 463 km^3(IFREMER), respectively. For this period, a mean monthly volume flux(area flux) difference between the estimates derived from the NSIDC and IFREMER drift data is –62 km^3 per month(–18×10~6 km^2 per month).Analysis reveals that this negative bias is mainly attributable to faster IFREMER drift speeds in comparison with slower NSIDC drift data. NSIDC-based sea ice volume flux estimates are compared with the results from the University of Bremen(UB), and the two products agree relatively well with a mean monthly bias of(5.7±45.9) km^3 per month for the period from January 2011 to August 2013. IFREMER-based volume flux is also in good agreement with previous results of the 1990 s. Compared with P1(1990/1991–1993/1994) and P2(2003/2004–2007/2008), the WAVF estimates indicate a decline of more than 600 km^3 in P3(2011/2012–2014/2015). Over the three periods, the variability and the decline in the sea ice volume flux are mainly attributable to sea ice motion changes, and second to sea ice thickness changes, and the least to sea ice concentration variations. | BI Haibo WANG Yunhe ZHANG Wenfeng ZHANG Zehua LIANG Yu ZHANG Yi HU Wenmin FU Min HUANG Haijun | 2018 | Acta Oceanologica Sinica2018，37，9： | 2 |
| 3 | Termination of Transcription of LAT Increases the Amounts of ICP0 mRNA but Does Not Alter the Course of HSV-1 Infection in Latently Infected Murine Ganglia显示文摘On entering sensory ganglia,herpes simplex viruses 1(HSV-1)establishes a latent infection with the synthesis of a latency associated transcript(LAT)or initiates productive infection with expression of a set of immediate early viral proteins.The precise mechanisms how expression of a genes is suppressed during the latency are unknown.One mechanism that has been proposed is illustrated in the case of ICP0,a key immediate early viral regulatory protein.Specifically,the 2 kb LAT intron is complementary to the 30 terminal portion of ICP0 m RNA.To test the hypothesis that accumulation of LAT negatively affects the accumulation of ICP0 m RNA,we inserted a DNA fragment encoding two poly(A)sequences into LAT to early terminate LAT transcript without interrupting the complementary sequence of ICP0 transcript(named as SR1603).Comparisons of the parent(SR1601)and mutant(SR1603)HSV-1 viruses showed the following:Neurons harboring latent SR1603 virus accumulated equivalent amounts of viral DNA but higher amounts of ICP0 m RNA and lower amounts of LAT,when compared to neurons harboring the SR1601 virus.One notable difference between the two viruses is that viral RNA accumulation in explanted ganglia harboring SR1603 virus initiated significantly sooner than that in neurons harboring SR1601 virus,suggesting that ICP0 may act as an activator of viral gene expression in permissive cells.Collectively,these data suggest that increased ICP0 m RNA by suppressed LAT did not affect the establishment of latency in latently infected murine ganglia. | Haifang Jiang Jiaming Wu Xianjie Liu Ruitao Lu Manling Zhou Meiling Chen Yonghong Liu Grace Guoying Zhou Wenmin Fu | 2021 | Virologica Sinica2021，36，2： | 2 |
| 4 | Nitrogen-rich azoles as trifunctional electrolyte additives for high-performance lithium-sulfur battery显示文摘Rechargeable lithium-sulfur(Li-S)batteries are considered one of the most promising energy storage techniques owing to the high theoretical energy density.However,challenges still remain such as the shuttle effect of lithium polysulfides(LPSs)and the instability of lithium metal anode.Herein,we propose to use nitrogen-rich azoles,i.e.,triazole(Ta)and tetrazole(Tta),as trifunctional electrolyte additives for Li-S batteries.The azoles afford strong lithiophilicity for the chemisorption of LPSs.The density functional theory and experimental analysis verify the presence of Li bonds between the azoles and LPSs.The azoles can also interact with lithium salt in the electrolyte,leading to increase ionic conductivity and lithiumion transference number.Moreover,the azoles render particle-like lithium deposition on the lithium metal anode,leading to superlong cycling of a Li symmetric cell.The Li-S batteries with Ta and Tta exhibit the initial discharge capacity of 1425.5 and 1322.2 m Ah g^(-1),respectively,at 0.2 C rate,and promising cycling stability.They also enable enhanced cycling performance of a Li-organosulfide battery. | Dan-Yang Wang Wenmin Wang Fengli Li Xin Li Wei Guo Yongzhu Fu | 2022 | Journal of Energy Chemistry2022，31，8： | 1 |
| 5 | Determination of China's black list of pollutants subject to priority control in water 显示文摘 | Zhou Wenmin Fu Deqian Sun Zongguang | 1991 | Environmental Science Study1991，4，6： | 1 |
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