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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014，20，7： | 5 |
| 3 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 4 | Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya显示文摘 | Wendy P O'Meara Phillip Bejon Tabitha W Mwangi Emelda A Okiro Norbert Peshu Robert W Snow Charles RJC Newton Kevin Marsh | 2008 | The Lancet2008，，9649： | 2 |
| 5 | Seed size,number,and habitat of a fleshy-fruited plant:consequences for seedling establishment显示文摘 | WENDY P | 2002 | Ecology2002，83，3： | 1 |
| 6 | Wavelet entropy for subband segmentation of EEG during in- jury and recover显示文摘 | Hasan A A Joseph S P Wendy C Z | 2003 | Annals of Biomedical Engineer- ing2003，31，6： | 1 |
| 7 | High-throughput sequencing for biology and medicine显示文摘 | Wendy Weijia Soon Manoj Hariharan Michael P Snyder | 2013 | Molecular Systems Biology2013，22，1： | 1 |
| 8 | Managemnent strategy impacts on ammonia volatilization from swine manure 显示文摘 | Daine M P Wendy J P Jeffery C L | 2005 | J Environ Qual2005，34，： | 1 |
| 9 | Conformity to sex-typed norms, affect, and the self-concept显示文摘 | WENDY W P NIELS C MICHELLE R H | 1997 | Journal of Prsonality and Social Psychology1997，73，3： | 1 |
| 10 | An application-specific protocol architecture for wireless microsensor networks显示文摘 | Wendi B Heinzelman Anantha P Chandrakasan Hari Balakrishnan | 2002 | IEEE Transactions on Wireless Communications2002，4，1： | 1 |
| 11 | The Risk of Catheter-related Bloodstream Infection with Femoral Venous Catheters asCompared to Subclavian and Internal Jugular Venous Catheters: A Systematic Review of the Literature and Meta- analysis显示文摘 | Marik P E Mark F Wendy H | 2012 | Critical Care Medicine2012，40，8： | 1 |
| 12 | Innovation diffusion model in patch environment显示文摘 | Wang Wendi Fergola P | 2003 | Applied Mathematics and Computation2003，134，： | 1 |
| 13 | Electrochemical efficiency in muhiplc discharge cycling of supercapacitors in hybrid EV applications 显示文摘 | WENDY G P BRIAN E C WILLIAN A | 1999 | J Power Sources1999，80，1： | 1 |
| 14 | Innovation diffusion model in patch Environment 显示文摘 | Fergola P | 2003 | Applied Mathematics and Computation2003，134，： | 1 |
| 15 | Peculiarities and requirements of asymmetric capacitor devices based on combination of capacitor and battery-type electrodes显示文摘 | WENDY P BRIAN E C | 2004 | J Power sources2004，136，： | 1 |
| 16 | Seed size,number,and habitat of a fleshy-fruited plant: consequences for seedling establishment显示文摘 | Wendy P | 2002 | Ecology2002，83，3： | 1 |
| 17 | An application-specific protocol architecture for wireless microsensor networks显示文摘 | Anantha P Chandrakasan Hari Balakrishnan | 2002 | IEEE Trans on Wireless Comm2002，1，4： | 1 |
| 18 | An integrated inventorytransportation system with modified periodic policy for multiple products显示文摘 | Wendy W Q Bookbinder J H Iyogun P | 1999 | European Journal of Operational Research1999，11，5： | 1 |
| 19 | The Interaction of Particle and Material BehaviourinErosionProcesses显示文摘 | Tiny G P Sage Wendy | | Wear0，16，6： | 1 |
| 20 | An application-specific protocol architecture for wirelessmicrosensor networks显示文摘 | WENDI B HEINZELMAN CHANDRAKASAN A P | 2002 | IEEE2002，，1： | 1 |
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