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| 1 | Toward point-of-care management of chronic respiratory conditions:Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide显示文摘We present a portable non-invasive approach for measuring indicators of inflammation and oxidative stress in the respiratory tract by quantifying a biomarker in exhaled breath condensate(EBC).We discuss the fabrication and characterization of a miniaturized electrochemical sensor for detecting nitrite content in EBC using reduced graphene oxide.The nitrite content in EBC has been demonstrated to be a promising biomarker of inflammation in the respiratory tract,particularly in asthma.We utilized the unique properties of reduced graphene oxide(rGO);specifically,the material is resilient to corrosion while exhibiting rapid electron transfer with electrolytes,thus allowing for highly sensitive electrochemical detection with minimal fouling.Our rGO sensor was housed in an electrochemical cell fabricated from polydimethyl siloxane(PDMS),which was necessary to analyze small EBC sample volumes.The sensor is capable of detecting nitrite at a low over-potential of 0.7 V with respect to an Ag/AgCl reference electrode.We characterized the performance of the sensors using standard nitrite/buffer solutions,nitrite spiked into EBC,and clinical EBC samples.The sensor demonstrated a sensitivity of 0.21μAμM^(−1) cm^(−2) in the range of 20–100μM and of 0.1μAμM^(−1) cm^(−2) in the range of 100–1000μM nitrite concentration and exhibited a low detection limit of 830 nM in the EBC matrix.To benchmark our platform,we tested our sensors using seven pre-characterized clinical EBC samples with concentrations ranging between 0.14 and 6.5μM.This enzyme-free and label-free method of detecting biomarkers in EBC can pave the way for the development of portable breath analyzers for diagnosing and managing changes in respiratory inflammation and disease. | Azam Gholizadeh Damien Voiry Clifford Weisel Andrew Gow Robert Laumbach Howard Kipen Manish Chhowalla Mehdi Javanmard | 2017 | Microsystems & Nanoengineering2017，3，1： | 5 |
| 2 | Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins显示文摘 | Tai-Wing Wu K.P. Fung Jun Wu Chih-Chin Yang Richard D. Weisel | 1996 | Biochemical Pharmacology1996，，6： | 2 |
| 3 | Autologous transplantation of bone marrow cells improves damaged heart function 显示文摘 | Li RK Weisel RD | 1999 | Circ1999，100，19： | 1 |
| 4 | Rhabdomyolysis and acute kidney injury显示文摘 | Heyne N Guthoff M Weisel KC | 2009 | N Engl J Med2009，361，14： | 1 |
| 5 | Cardiac re-modeling and failure : from molecules to man ( Part 1 ) 显示文摘 | Fedak 1' W Verma S Weisel R D | 2005 | Cardiovasc: Pathol2005，14，： | 1 |
| 6 | Risk factors for stroke following coronary bypass surgery显示文摘 | RAO V CHRISTAKIS G T WEISEL R D | 1995 | J Card Surg1995，10，4： | 1 |
| 7 | Autologous porcine heart cell transplantation improved heart funtion after a myocardial infraction 显示文摘 | LI RK Weisel RD Mickle DA | 2000 | J Thorac Cardiovasc Surg2000，119，1： | 1 |
| 8 | Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation 显示文摘 | Tomita S Mickle DA Weisel RD | 2002 | J Thorac Cardiovasc Surg2002，123，6： | 1 |
| 9 | Autologous porcine heart cell transplantation improved heart function after a myocardial infarction V显示文摘 | Li RK Weisel RD Mickle DA | 2000 | J Thorac Cardiovasc Surg2000，119，： | 1 |
| 10 | Autologous transplantation of bone marrow cells improves damaged heart function显示文摘 | Tomita S Li RK Weisel RD | 1999 | Circulation1999，100，19： | 1 |
| 11 | Venom of a parasitoid wasp induces prolonged grooming in the cockroach 显示文摘 | Weisel EA Haspel G Libersat F | 1999 | J Experimental Biol1999，202，8： | 1 |
| 12 | Advances in Protein Chemistry显示文摘 | Weisel J W | 2005 | 2005, 70: 2472005，70，： | 1 |
| 13 | Body mass index as an indicator of obesity显示文摘 | Weisell RC | 2002 | Asia Pac J Clin Nutr2002，11，8： | 1 |
| 14 | Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma(MM-003):a randomised,open-label,phase 3trial显示文摘 | San Miguel J Weisel K Moreau P | 2013 | Lancet Oncol2013，14，11： | 1 |
| 15 | Fundamentals of reperfusion injury for the clinical cardiologist显示文摘 | Verma S Fedak PW Weisel R | 2002 | Circulation2002，105，20： | 1 |
| 16 | Cardiac remodelingand failure:from molecules to man显示文摘 | Fedak PW Verma S Weisel RD | 2005 | Cardiovasc Pathol2005，14，： | 1 |
| 17 | Childhood asthma and environmental exposures at swimming pools: state of the science and research recommendations 显示文摘 | Weisel C P' Richardson S D Nemery B | 2009 | Environmental Health Per- spectives2009，117，4： | 1 |
| 18 | Autologous transplantation of bone marrow cells improves damaged heart function 显示文摘 | Li R - K Weisel RD | 1999 | Circulation1999，100，19： | 1 |
| 19 | Intraoperative myocardial protection:current trends and future perspectives显示文摘 | Cohen G Borger MA Weisel RD | 1999 | Ann Thorac Surg1999，68，5： | 1 |
| 20 | Heart cell transplantation in dialated cardiomyopathic hamsters 显示文摘 | Yoo KJ Li RK Weisel RD | 2000 | Circulation2000，102，： | 1 |
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