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| 1 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 2 | MR imaging and spectroscopy in clinical and experimental cerebral ischaemia:a review显示文摘 | Brant-Zawadzki M Weinstein P Bartkowski H | 1987 | AJNR1987，148，3： | 1 |
| 3 | A study of rituximab and ifosfamide,carboplatin,and etoposide chemotherapy in children with recurrent/refractory B-cell (CD20 +) non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia:a report from the Children's Oncology Group显示文摘 | Griffin TC Weitzman S Weinstein H | 2009 | Pediatr Blood Cancer2009，52，： | 1 |
| 4 | Brain imaging in patients with diabetes: a systematic review显示文摘 | Van Harten B De Leeuw F E Weinstein H C | 2006 | Diabetes Care2006，29，11： | 1 |
| 5 | Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta显示文摘 | Weinstein S L Finn A J Dave S H | 2000 | J Leukoc Biol2000，67，： | 1 |
| 6 | Mapping pathophysiological features of breast tumors by MRI at high spatial resolution显示文摘 | Degani H Gusis V Weinstein D | 1997 | Nat Meal1997，3，7： | 1 |
| 7 | Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells 显示文摘 | Li H Weinstein IB | 2006 | Cancer Res2006，66，11： | 1 |
| 8 | Uptake of fluoride and aluminum by plants grown in contaminated soils显示文摘 | BRAEN S N WEINSTEIN L H | 1985 | Water Air Soil Pollut1985，24，： | 1 |
| 9 | A review of breast ultrasound显示文摘 | Sehgal C M Weinstein S P Arger P H | 2006 | J Mammary Gland Biol Neoplasia2006，11，2： | 1 |
| 10 | Spine fellowship education and its association with the part-II oral certification examination显示文摘 | Herkowitz H N Weinstein J N Callaghan J J | 2006 | J Bone Joint Surg Am2006，88，3： | 1 |
| 11 | Induction of autoimmunity by pristane and other naturally-occurring hydrocarbons显示文摘 | Reeves W H Lee P Y Weinstein J S | 2009 | Trends Immunol2009，30，9： | 1 |
| 12 | Neuropsyehology of cognitive ageing,minimal cognitive impairment,Alzhdmer's disease, and vascular cognitive ira-pairmeut 显示文摘 | Lindeboom J Weinstein H | 2004 | Eur J Pharmacol2004，490，13： | 1 |
| 13 | Central administration of methotrexate reduces mechanical allodyma in an animal model of radieulopathy/sentical 显示文摘 | Hashizume H Rutkowski MD Weinstein JN | 2000 | Pain2000，87，2： | 1 |
| 14 | Overexpression of p53 tumor suppressor gene in pterygia 显示文摘 | Weinstein O Rostenthal G Zirkin H | 2002 | E ye2002，16，5： | 1 |
| 15 | A Study of Rituximab and ifosfamide,carboplatin,and etoposide chemotherapy in children with recurrent/refractory B - cell ( CD20 + ) non - Hodgkin lymphoma and mature B- cell acute lymphoblastic leukemia:A report from the Chil- dren's Oncology Group 显示文摘 | Griffin TC Weitzman S Weinstein H | 2009 | Pediatr Blood Cancer2009，52，2： | 1 |
| 16 | Antibiotic from Micromonospora显示文摘 | WAGMAN G H WEINSTEIN M J | 1980 | Annu Rev Microbiol1980，34，： | 1 |
| 17 | Biomechanics of transpedicle spinal fixation显示文摘 | Krag M H Wiesel S W Weinstein J N | 1990 | Spine1990，16，6： | 1 |
| 18 | Direct Two-phase Titration Method for Analyzing Anionic Nonsoap Surfactants in Fresh and Saline Waters显示文摘 | WEINSTEIN H POLITZER P SREBRENIK S | 1975 | Theor Chim Acta1975，38，： | 1 |
| 19 | Integrated methods for the con struction of three-dimensional models and computational pro bing of structure-function relations in G prolein coupled re ceptors显示文摘 | Ballesteros J Weinstein H | 1995 | Methods Neurosci1995，25，： | 1 |
| 20 | Overexpression of p55 tumor suppressor gene in pterygia 显示文摘 | Weinstein O Rosenthal G Zirkin H | 2002 | Eye2002，16，5： | 1 |
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