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| 1 | 第一极体形态学与人类卵细胞非整倍体相关关系的研究显示文摘目的 :探讨第一极体的形态学和卵细胞染色体非整倍体异常间的相关性 ,为使用第一极体作为移植胚胎的筛选指标提供理论依据。方法 :采用多色荧光原位杂交法分析卵细胞中 1 3 ,1 6,1 8,2 1和 2 2号染色体的核型 ,并结合第一极体的形态学进行相关分析。结果 :72 .3 %的卵细胞核型正常 ,2 7.7%的卵细胞为非整倍体 ;在 4组具有不同形态第一极体的卵细胞中 ,非整倍体的发生率分别为 1 4.7% ,1 7.4% ,2 9.7%和 61 .1 %。第 1组卵细胞非整倍体的发生率与第 4组相比 ,差异有高度显著性 (P <0 .0 0 1 )。结论 :第一极体的形态学和卵细胞的染色体非整倍体异常之间存在一定的相关性。由于其非整倍体的发生率高 ,由具有异常大小第一极体的卵细胞发育而来的胚胎不适用于移植。 | 陈雯 Schmutzler A Weimer J Mettler L | 2003 | 现代妇产科进展2003，12，5： | 3 |
| 2 | 多色荧光原位杂交检测人卵细胞染色体非整倍体方法的建立显示文摘目的 建立多色荧光原位杂交技术检测人卵细胞染色体非整倍体的方法。方法 取试管婴儿助孕技术后未能受精成功的卵细胞 ,于取卵后 1~ 3d固定 ,采用多色荧光原位杂交方法检测卵细胞 13,16 ,18,2 1和 2 2号染色体的情况。结果 正常未受精卵细胞中期染色体显示一个成对的杂交信号 ,每条染色单体显示一个单个信号 ;分裂相中多出或缺少一个成对杂交信号表明多余或缺少一条染色体 ;分裂相中多出或缺少一个单个信号表明多余或缺少一条染色单体 ;两个单个信号分离表明两条姐妹染色单体分离。结论 采用多色荧光原位杂交方法可以有效检测人卵细胞染色体非整倍体异常。 | 陈雯 Schmutzler A Weimer J | 2003 | 中国优生与遗传杂志2003，11，4： | 2 |
| 3 | Analysis of novel nonviral gene transfer systems for gene delivery to cells of the musculoskeletal sys- tem显示文摘 | Orth P Weimer A Kaul G | 2008 | Mol Biotechno12008，38，2： | 1 |
| 4 | Aggregation behavior of nanoparticles in fluidized beds 显示文摘 | HAKIM L PORTMAN J CSAPER M WEIMER A | 2005 | Powder Technol2005，160，3： | 1 |
| 5 | Coinfection withHaemophilus influenzae promotes pneumococcal biofilm formationduring experimental otitis media and impedes the progression ofpneumococcal disease显示文摘 | Weimer K E Armbruster C E Juneau R A | 2010 | J Infect Dis2010，202，7： | 1 |
| 6 | Genetic diversity of a Brazilian Creole cattle based on fourteen microsatellite loci显示文摘 | Steigleder C S Almeida E A Weimer T A | 2004 | Arch Zootec2004，53，： | 1 |
| 7 | Risk - based siting consid- erations for LNG terminals - comparative perspectives of United States & Europe 显示文摘 | LICARI F A WEIMER C D | 2011 | Journal of Loss Prevention in the Process Industries2011，24，： | 1 |
| 8 | Effects of chemical treatments and heating on the crystallinity of cellulose and their implications for evaluating the effect of crystallinity on cellulose biodegradation显示文摘 | WEIMER P J HACKNEY J M FRENCH A D | 1995 | Biotechnology and Bioengineering1995，48，： | 1 |
| 9 | Restoration of the extracel ular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9显示文摘 | Cucchiarini M Thurn T Weimer A | | 0，，： | 1 |
| 10 | Plasma diagnostics of a DC arc jet chemical vapor deposition diamond reactor显示文摘 | REEVE S W WEIMER W A | 1993 | Thin Solid Films1993，236，： | 1 |
| 11 | Rapid process for manufacturing aluminum nitride powder显示文摘 | Weimer A W Cochran G A Eisman G A | 1994 | Journal of the American Ceramic Society1994，77，1： | 1 |
| 12 | Model predietive control of a solar-thennal reactor显示文摘 | SAADE E CLOUGH D E WEIMER A W | 2014 | Solar Energy2014，102，： | 1 |
| 13 | DNA Maeroarray profiling of Lactococcus lactis subsp, lactis IL1403 gene expression during environmental stresses 显示文摘 | Xie Y Chou L S Cutler A Weimer B | 2004 | Appl Environ Microbiol2004，70，： | 1 |
| 14 | Effects of threeimmunosuppressive regimens on CD4helper function,B cellmonocyte and cytokine responses in renal transplantrecipients:4-month follow-up of a prospective randomizedstudy显示文摘 | Weimer R Streller S Staak A | 2002 | Transplant Proc2002，34，4： | 1 |
| 15 | Post-transplant sCD30 and neopterin as predictors of chronic allograftnephropathy:impact of different immunosuppressive regimens显示文摘 | Weimer R Süsal C Yildiz S Staak A Pelzl S Renner F | 2006 | Am J Transplant2006，6，： | 1 |
| 16 | Noncovalent engineering of carbon nanotube surfaces by rigid, functional conjugated polymers 显示文摘 | Chen Jian Liu Hui Weimer W A | 2002 | J Am Chem Soc2002，124，31： | 1 |
| 17 | 显示文摘 | Chen J Liu H Y Weimer W A | 2002 | J Am Chem Soc2002，124，31： | 1 |
| 18 | Effects of chemical treatments and heating on the crystallinity of celluloses and their implications for evaluating the effect of crystallinity on cellulose biodegradation显示文摘 | Weimer P J Hackney J M French A D | 1995 | Biotechnology and Bioengineer- ing1995，，48： | 1 |
| 19 | Noncovalent Engineering of Carbon Nanotube Surfaces by Rigid, Functional Conjugated Polymers显示文摘 | Chen J Liu H Weimer W A | 2002 | Journal of the American Chemical Society2002，124，31： | 1 |
| 20 | Effects of chemical treatments and heating on the crystallinity of celluloses and their implications for evaluating the effect of crystallinity on cellulose biodegradation显示文摘 | Weimer P J Hackney J M French A D | 1995 | Biotechnology and Bioengineer-ing1995，，48： | 1 |
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