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| 1 | Grey matter volume abnormalities in patients with bipolar I depressive disorder and unipolar depressive disorder:a voxelbased morphometry study显示文摘Bipolar disorder and unipolar depressive disorder(UD) may be different in brain structure. In the present study,we performed voxel-based morphometry(VBM) to quantify the grey matter volumes in 23 patients with bipolar I depressive disorder(BP1) and 23 patients with UD,and 23 age-,gender-,and educationmatched healthy controls(HCs) using magnetic resonance imaging. We found that compared with the HC and UD groups,the BP1 group showed reduced grey matter volumes in the right inferior frontal gyrus and middle cingulate gyrus,while the UD group showed reduced volume in the right inferior frontal gyrus compared to HCs. In addition,correlation analyses revealed that the grey matter volumes of these regions were negatively correlated with the Hamilton depression rating scores. Taken together,the results of our study suggest that decreased grey matter volume of the right inferior frontal gyrus is a common abnormality in BP1 and UD,and decreasedgrey matter volume in the right middle cingulate gyrus may be specifi c to BP1. | Yi Cai Jun Liu Li Zhang Mei Liao Yan Zhang Lifeng Wang Hongjun Peng Zhong He Zexuan Li Weihui Li Shaojia Lu Yuqiang Ding Lingjiang Li | 2015 | Neuroscience Bulletin2015，31，1： | 11 |
| 2 | Is kinase activity essential for biological functions of BRI1?显示文摘Brassinosteroids (BR ) 是植物激素的一个主要的组调整植物生长和开发。BRI1,对质膜局部性的蛋白质,当 BR 受体和它被建议了,工作它的 kinase 活动在调整 BR 的植物生长和开发有一个必要角色。这里,我们报导隔离和 bri1 的新等位基因的分子的描述, bri1-301,哪个表演中等词法显型和减少的回答到在正常生长条件下面的 BR。顺序分析从 GG 识别了二底的改变到,导致到在 BRI1 kinase 领域的 989I 的 989G 的变换在。kinase 活动的试管内试金证明 bri1-301 不向 BRI1 底层 TTL 和 BAK1 举办可检测的 autophosphorylation 活动或磷酸化活动。而且,我们的结果建议甚至与极其损害的 kinase 活动, bri1-301 仍然在调整植物生长和开发保留部分功能,它提出 BRI1 kinase 活动是否在高等植物为调停 BR 的生长和开发是必要的问题。 | Weihui Xu Juan Huang Baohua Li Jiayang Li Yonghong Wang | 2008 | Cell Research2008，18，4： | 9 |
| 3 | A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis显示文摘To investigate the effect of basal hormone levels including follicle stimulating hormone(FSH) and estradiol(E2) and age on the pregnancy outcomes in women undergoing in vitro fertilization and embryo transfer(IVF-ET), we designed a retrospective cohort analysis and collected information of patients undergoing IVF between January 2014 and April 2017. We found that young women had much better pregnancy outcomes than older women regardless of the hormone levels. The pregnancy outcomes declined in young women with high basal E2, even though they had normal FSH. Older women with higher FSH had a worse outcome of pregnancy, especially with increased E2 level. The results suggest that a combination of FSH, E2 and age could effectively predict the pregnancy outcome for women undergoing IVF-ET, and we should encourage infertile women with diminished ovarian reserve, especially young infertile women, to try the assisted reproduction as early as possible. After 40-yearold, the cost-benefit ratio should be considered according to the ovarian function. | Ziru Jiang Li Jin Weihui Shi Ji Xi Yulian Hu Xinmei Liu Jianzhong Sheng Guolian Ding Hefeng Huang | 2019 | Science China(Life Sciences)2019，62，1： | 7 |
| 4 | Atomistic Surface Passivation of CH_(3)NH_(3)PbI_(3) Perovskite Single Crystals for Highly Sensitive Coplanar-Structure X-Ray Detectors显示文摘Organic-inorganic halide perovskites(OIHPs)are recognized as the promising next-generation X-ray detection materials.However,the device performance is largely limited by the ion migration issue of OIHPs.Here,we reported a simple atomistic surface passivation strategy with methylammonium iodide(MAI)to remarkably increase the ion migration activation energy of CH_(3)NH_(3)PbI_(3)single crystals.The amount of MAI deposited on the crystal surface is finely regulated by a self-assemble process to effectively suppress the metallic lead defects,while not introducing extra mobile ions,which results in significantly improved dark current stability of the coplanar-structure devices under a large electric field of 100Vmm^(-1).The X-ray detectors hence exhibit a record-high sensitivity above 700,000μC Gy^(-1)_(air) cm^(-2)under continuum X-ray irradiation with energy up to 50 keV,which enables an ultralow X-ray detection limit down to 1.5 nGy_(air)s^(-1).Our findings will allow for the dramatically reduced X-ray exposure of human bodies in medical imaging applications. | Yilong Song Liqi Li Weihui Bi Mingwei Hao Yifei Kang Anran Wang Zisheng Wang Hanming Li Xiaohui Li Yanjun Fang Deren Yang Qingfeng Dong | 2020 | Research2020，，1： | 5 |
| 5 | miR-155 aggravates impaired autophagy of pancreatic acinar cells through targeting Rictor显示文摘The aim of this study was to investigate the role and mechanism of miR-155 in regulating autophagy in a caerulein-induced acute pancreatitis(AP)cellular model.GFP-LC3 immunofluo-rescence assay was performed to detect autophagy vesicle formation in pancreatic acinar cell line AR42J.AR42J cells were transfected with miR-155 mimic,inhibitor,and corresponding controls to explore the effect of miR-155 on autophagy.The protein levels of LC3-I,LC3-11,Beclin-1,and p62 were analyzed by western blot analysis.Dual-luciferase reporter assay was performed to verify the interaction between miR-155 and Rictor(RPTOR independent companion of MTOR complex 2).The results showed that caerulein treatment induced impaired autophagy as evi-denced by an increase in the accumulation of p62 together with LC3-11 in AR42J cells,accompanied by miR-155 upregulation.Furthermore,miR-155 overexpression aggravated,whereas miR-155 silencing reduced the caerulein-induced impairment of autophagy.Mechanistically,Rictor was confirmed to be a direct target of miR-155,which could rescue the miR-155 overexpression-mediated aggravation of im paired autophagy.Collectively,these findings indicate that miR-155 aggravates impaired autophagy in caerulein-treated pancreatic acinar cells by targeting Rictor. | Xueming Zhang Jiangtao Chu Haijun Sun Dali Zhao Biao Ma Dongbo Xue Weihui Zhang Zhituo Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 4 |
| 6 | Defining a critical period in calvarial development for Hedgehog pathway antagonist-induced frontal bone dysplasia in mice显示文摘The Hedgehog(Hh) signalling pathway is essential for cellular proliferation and differentiation during embryonic development.Gain and loss of function of Hh signalling are known to result in an array of craniofacial malformations. To determine the critical period for Hh pathway antagonist-induced frontal bone hypoplasia, we examined patterns of dysmorphology caused by Hh signalling inhibition. Pregnant mice received a single oral administration of Hh signalling inhibitor GDC-0449 at 100 or 150 mg·kg^(-1) body weight at preselected time points between embryonic days(E)8.5 and 12.5. The optimal teratogenic concentration of GDC-0449 was determined to be 150 mg·kg^(-1). Exposure between E9.5 and E10.5 induced frontal bone dysplasia, micrognathia and limb defects, with administration at E10.5 producing the most pronounced effects. This model showed decreased ossification of the frontal bone with downregulation of Hh signalling. The osteoid thickness of the frontal bone was significantly reduced. The amount of neural crest-derived frontal bone primordium was reduced after GDC-0449 exposure owing to a decreased rate of cell proliferation and increased cell death. | Yuanjing Jiang Shixian Zhang Chuanqing Mao Yongzhen Lai Di Wu Hu Zhao Caiyu Liao Weihui Chen | 2019 | International Journal of Oral Science2019，11，1： | 2 |
| 7 | Effects of leukemia inhibitory factor and basic fibroblast growth factor on free radicals and endogenous stem cell proliferation in a mouse model of cerebral infarction显示文摘The present study established a mouse model of cerebral infarction by middle cerebral artery occlusion,and monitored the effect of 25 μg/kg leukemia inhibitory factor and(or) basic fibroblast growth factor administration 2 hours after model establishment.Results showed that following administration,the number of endogenous neural stem cells in the infarct area significantly increased,malondialdehyde content in brain tissue homogenates significantly decreased,nitric oxide content,glutathione peroxidase and superoxide dismutase activity significantly elevated,and mouse motor function significantly improved as confirmed by the rotarod and bar grab tests.In particular,the effect of leukemia inhibitory factor in combination with basic fibroblast growth factor was the most significant.Results indicate that leukemia inhibitory factor and basic fibroblast growth factor can improve the microenvironment after cerebral infarction by altering free radical levels,improving the quantity of endogenous neural stem cells,and promoting neurological function of mice with cerebral infarction. | Weihui Huang Yadan Li Yufeng Lin Xue Ye Dawei Zang | 2012 | Neural Regeneration Research2012，7，19： | 2 |
| 8 | Roll motion of a roroship in ir- regular following waves 显示文摘 | HUA Jianbo WANG Weihui | 2001 | Journal of marine science and technology2001，9，1： | 1 |
| 9 | Website browsing aid: A navigation graph-based recommenda- tion system 显示文摘 | WANG Youwei DAI Weihui YUAN Yufei | 2008 | Decision Support Systems2008，45，3： | 1 |
| 10 | Prediction of pitting corrosion behavior for stainless SUS 630 based on grey system theory 显示文摘 | MA Fongyuan WANG Weihui | 2007 | Materials Letters2007，61，45： | 1 |
| 11 | Diagnosis and control of machine induced noise and vibration in steel construction显示文摘 | Lu Weiyu Wang Weihui | 2008 | Journal of Mechanical Science and Technology2008，22，： | 1 |
| 12 | A novel red phosphor NaLa 4 (SiO 4 ) 3 F: Eu 3+显示文摘 | Guo Feng Weihui Jiang Yibin Chen Renjie Zeng | 2010 | Materials Letters2010，，1： | 1 |
| 13 | Risk assessment for transformer loading显示文摘 | Fu Weihui McCalley J D Vittal V | 2001 | IEEE Transactions on Power Systems2001，16，3： | 1 |
| 14 | Direct manufacturing of Cu-based alloy parts by selective laser melting显示文摘 | Wu Weihui Yang Yongqiang Huang Yanlu | 2007 | Chinese Optics Letters2007，43，4： | 1 |
| 15 | An improved ant colony optimization cluster algorithm based on swarm intelligence显示文摘 | Weihui Dai Shouji Liu Shuyi Liang | 2009 | Journal of Software2009，4，4： | 1 |
| 16 | Direct manufacture of Cu-based alloy parts by selective laser melting显示文摘 | Wu Weihui Yang Yongqiang Huang Yanlu | 2007 | Chin Opt Lett2007，5，1： | 1 |
| 17 | Abdominal paracentesis drainage ahead of percutaneous catheter drainage benefits patients at- tacked by acute pancreatitis with fluid collections: a retrospective clinical cohort study显示文摘 | LIU Weihui REN Lina CHEN Tao | 2015 | Critical Care Medicine2015，43，1： | 1 |
| 18 | Roll motion of a roro-ship in irregular following waves显示文摘 | HUA Jianbo WANG Weihui | 2001 | Journal of Marine Science and Technology2001，9，1： | 1 |
| 19 | A study of the hydrodynamic characteristics of a vertical water wall in a 2953 t/h ultra- supercritical pressure boiler显示文摘 | Zhu Xiaojing Wang Weishu Xu Weihui | 2015 | In- ternational Journal of Heat and Mass Transfer2015，86，： | 1 |
| 20 | A novel red phosphor NaLa4 ( SiO4 ) 3 F: Eu^3+ 显示文摘 | Guo F Weihui J Yibin C | 2011 | Materials Letters2011，65，1： | 1 |
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