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| 1 | Emodin ameliorates cisplatin-induced apoptosis of rat renal tubular cells in vitro by activating autophagy显示文摘目的: 一份以前的报告显示出从中国植物大黄和巨大的 knotweed 根茎提取的那 emodin 能改善 anticancer 药 HEK293 房间的导致 cisplatin 的损害。在这研究,我们调查了是否并且 emodin 怎么能在 vitro.Methods 保护肾的管状的上皮的房间免于导致 cisplatin 的 nephrotoxicity : 正常老鼠的生存能力和 apoptosis 肾的管状的上皮的房间(NRK-52E ) 被检测分别地使用 formazan 试金和流动 cytometry 分析。表明小径相关的蛋白质的劈开的 caspase-3, autophagy 制造者 LC3 I/II,和 AMPK/mTOR 的表示层次与西方的污点分析被测量。形态学和 RFP-LC3 荧光的变化在 microscopy.Results 下面被观察: Cisplatin (10-50 μ mol/L ) , dose-dependently 在 NRK-52E 房间导致了房间损坏和 apoptosis emodin (10 和 100 μ mol/L ) 显著地改善的导致 cisplatin 的房间损坏, apoptosis 和 caspase-3 劈开。Emodin dose-dependently 增加了 LC3-II 层次并且导致了 RFP-LC3-containing 在 NRK-52E 房间的有小斑点的结构。而且, emodin 的保护的效果被 bafilomycin A1 (10 nmol/L ) 废除,并且由 rapamycin (100 nmol/L ) 模仿了。而且, emodin 增加了 AMPK 的 phosphorylation 并且压制了 mTOR 的 phosphorylation。AMPK 禁止者混合物 C (10 μ mol/L ) 不仅废除导致 emodin 的 autophagy 激活,而且导致 emodin 的 anti-apoptotic effects.Conclusion : Emodin 改善老鼠的导致 cisplatin 的 apoptosis 在通过 modulating 的 vitro 的肾的管状的房间表明小径并且激活 autophagy 的 AMPK/mTOR。Emodin 可以为导致 cisplatin 的 nephrotoxicity 的预防有治疗学的潜力。 | Hong LIU Liu-bao GU Yue TU Hao HU Yan-ru HUANG WeiSUN | 2016 | Acta Pharmacologica Sinica2016，37，2： | 12 |
| 2 | Studies on the Interaction of BeryllonⅢwith Proteins by Voltammetric Technique and its Application显示文摘A new quantitative determination method of proteins using beryllon Ш by voltammetric technique was developed in this paper. In pH 3.5 Britton-Robinson (B-R) buffer solution, beryllon Ш can bind with human serum albumin (HSA) to form an electro-inactive supermolecular complex. Beryllon Ш has a well-defined voltammetric reduction peak at -0.38 V (vs. SCE) and the addition of protein in this solution can cause the decrease of the reductive peak current. Based on the decrease of the reduction peak current, a new electrochemical method for the determination of HSA was established with linear range of 1.0~40.0 mg/L and the detection limit of 1.0 mg/L. This method is further applied to the determination of real sample of healthy human serum. | WeiSUN KuiJIAO XueLiangWANG LuDeLU | 2003 | Chinese Chemical Letters2003，14，12： | 5 |
| 3 | Displacement of surrounding rock in a deep circular hole considering double moduli and strength-stiffness degradation显示文摘The problem of cavity stability widely exists in deep underground engineering and energy exploitation.First,the stress field of the surrounding rock under the uniform stress field is deduced based on a post-peak strength drop model considering the rock’s characteristics of constant modulus and double moduli.Then,the orthogonal non-associative flow rule is used to establish the displacement of the surrounding rock under constant modulus and double moduli,respectively,considering the stiffness degradation and dilatancy effects in the plastic region and assuming that the elastic strain in the plastic region satisfies the elastic constitutive relationship.Finally,the evolution of the displacement in the surrounding rock is analyzed under the effects of the double modulus characteristics,the strength drop,the stiffness degradation,and the dilatancy.The results show that the displacement solutions of the surrounding rock under constant modulus and double moduli have a unified expression.The coefficients of the expression are related to the stress field of the original rock,the elastic constant of the surrounding rock,the strength parameters,and the dilatancy angle.The strength drop,the stiffness degradation,and the dilatancy effects all have effects on the displacement.The effects can be characterized by quantitative relationships. | Zenghui ZHAO WeiSUN Shaojie CHEN Yuanhui FENG Weiming WANG | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，12： | 2 |
| 4 | The test and analysis of a 3-stage reconnection coilgun显示文摘 | SHUN Shougao CHENG Weisun | | 0，，01： | 1 |
| 5 | Focusing on the major function‐oriented zone: A new spatial planning approach and practice in China and its 12th Five‐Year Plan 关注主体功能区——中国“十二五规划”新的空间规划探索与实践显示文摘 | JieFan 樊杰 WeiSun 孙威 ZhenshanYang 杨振山 PengFan 凡芃 DongChen 陈东 | 2012 | Asia Pacific Viewpoint2012，，1： | 1 |
| 6 | A note on Fuzzy information measures显示文摘 | Shang Xiugang Jiang Weisun | 1997 | Pattern Recgnition Letters1997，184，： | 1 |
| 7 | A novel stochastic optimization algorithm 显示文摘 | Bing Li Weisun Jiang | 2000 | IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS - PART B: CYBERNETICS2000，30，1： | 1 |
| 8 | Connexin 43 Reverses Malignant Phenotypes of Glioma Stem Cells by Modulating E‐Cadherin显示文摘 | Shi‐CangYu Hua‐LiangXiao Xue‐FengJiang Qing‐LiangWang YanLi Xiao‐JunYang Yi‐FangPing Jiang JieDuan Jian‐YongJiang Xian‐ZongYe Sen‐LinXu Yang‐HongXin Xiao‐HongYao Jian‐HongChen Wei‐HuaChu WeiSun BingWang Ji MingWang XiaZhang Xiu‐WuBian | 2012 | STEM CELLS2012，，2： | 1 |
| 9 | Identification of proteins differentially expressed between capillary endothelial cells of hepatocellular carcinoma and normal liver in an orthotopic rat tumor model using 2‐D DIGE显示文摘 | JinghuiJia JingyuWang MingTeh WeiSun JianhuaZhang IreneKee Pierce K.‐H.Chow Rosa Cynthia M.‐Y.Liang Maxey C. M.Chung RuowenGe | 2010 | Proteomics2010，，2： | 1 |
| 10 | The Haar wavelets operational matrix of integration显示文摘 | Guf Jinsheng Jiang Weisun | | 0，，07： | 1 |
| 11 | Two methods of muhiple models control for nonlinear process显示文摘 | Zhou Chaojun Jiang Weisun | 1994 | Signal and Control (China)1994，23，6： | 1 |
| 12 | Optimizing complex functions by chaos search显示文摘 | Li Bin Jiang Weisun | 1998 | Cybernetics and Systems1998，29，4： | 1 |
| 13 | Identification of proteins differentially expressed between capillary endothelial cells of hepatocellular carcinoma and normal liver in an orthotopic rat tumor model using 2‐D DIGE显示文摘 | JinghuiJia JingyuWang MingTeh WeiSun JianhuaZhang IreneKee Pierce K.‐H.Chow Rosa Cynthia M.‐Y.Liang Maxey C. M.Chung RuowenGe | 2010 | Proteomics2010，，2： | 1 |
| 14 | The Haar wavelets operational matrix of integration 显示文摘 | GU Jinsheng JIANG Weisun | 1996 | Int J of Systems Science1996，27，7： | 1 |
| 15 | A Mild and Efficient Oxidation of Alcohols in Water显示文摘A mild and efficient oxidation of alcohols to the corresponding carbonyl compounds using the PhI(OAc)2 (1.1 eq.) with n-Bu4NBr (8 mol %) in water at room temperature is described. This new procedure is very simple and affords the desired carbonyl compounds in high yields. | ChuanZhiXU LinCHEN ZhenLI WeiSUN ChunGuXIA | 2004 | Chinese Chemical Letters2004，15，10： | 1 |
| 16 | Optimizing complex func-tion by chaos search显示文摘 | Li Bing Jiang Weisun | 1998 | Cybernetics and Systems1998，29，4： | 1 |
| 17 | Optimizing complex functions by chaos search显示文摘 | Bing Li Weisun Jiang | 1998 | International Journal of Cybernetics and System1998，29，： | 1 |
| 18 | The Haar wavelets operational matrix of integration显示文摘 | JIANG Weisun | 1996 | Int J of Systems Sci1996，27，7： | 1 |
| 19 | Electrochemical Studies of the Recognition Interaction of Rhodamine B with DNA显示文摘The recognition interaction of rhodamine B (RB) with DNA was studied in pH 7.5 Britton-Robinson (B-R) buffer solution by electrochemical techniques. An irreversible oxidation peak at glassy carbon electrode was obtained at +0.92V (vs. SCE). After the addition of DNA into the RB solution, the peak current of RB decreased apparently without the shift of peak potential. The electrochemical parameters such as the charge transfer coefficient a and the electrode reaction standard rate constant ks of RB in the absence and presence of DNA were determined, which did not change, indicating that a non-electroactive complex was formed, so the concentration of RB in the solution decreased and the peak current decreased correspondingly. | KuiJIAO QingJunLI WeiSUN ZhenYongWANG | 2005 | Chinese Chemical Letters2005，16，3： | 1 |
| 20 | Synthesis of a New Cobalt(Ⅱ)Complex and its Interaction with DNA显示文摘A new complex of bis(N-benzyl benzotriazole-N3) dichloro Co(II) (Co(II)L2Cl2) was synthesized and its crystal was characterized. The interaction of this new complex with fs-DNA was studied by electrochemical and UV spectrophotometric method. In 0.01 mol/L pH 4.2 Tris-HCl buffer solution Co(II)L2Cl2 has two reductive peaks with peak potentials at 0.38 V and 0.27 V, respectively, and an oxidative peak at 1.05 V. After the addition of DNA, the peak currents decrease and the peak potential at 0.27 V shifts negatively. The UV spectrophotometric experiment indicates that the maximum absorbance of Co(II)L2Cl2 at 204 nm decreases and exhibits bathochromic shift after the addition of DNA. All the results reveal that Co(II)L2Cl2 binds with DNA by intercalation as well as electrostatic interaction. | KuiJIAO QingXiangWANG WeiSUN FangFangJIAN | 2005 | Chinese Chemical Letters2005，16，4： | 0 |
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