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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | Tackling the Wicked Problem of Measuring What Matters:Framing the Questions显示文摘Purpose:Making policy makers,researcher,education leaders,and assessment developers aware that what matters in education assessment is a wicked problem that cannot be easily solved following traditional approaches.Design/Approach/Methods:Starting from the questions that what matters in education assessment,this article presented such questions as a wicked problem because there is no consensus,not right or wrong answer,and certain solutions may lead to side effects on students and society.Therefore,a new approach of ecology should be involved,and different education outcomes or intended qualities of learners are presented in complex relationships.Findings:Deciding what matters in education assessment is a wicked question.It is not a tame or technology problem and can be resolved by any conventional approaches.What is pivotal now is to decipher what matters in education and then what should be measured and ultimately how to measure.The ecology and collaborate approach deliberated in this article could expedite such a process.Originality/Value:This article advocates paradigm change in understanding and resolving one of the most urgent problems in education.It provides an ecology explanation of the relationships that exist among the different education outcomes and students’qualities.By guiding through the dissecting of the problem step by step,this article has demonstrated a unique angle of understanding the wicked problem. | Yong Zhao Michael Wehmeyer James Basham David Hansen | 2019 | ECNU Review of Education2019，2，3： | 3 |
| 3 | The application of multiplexed microemulsion electrokinetic chromatography for the rapid determination of log Pow values for neutral and basic compounds显示文摘 | WEHMEYER KR TU JA JIN YK | 2003 | LC-GC North America2003，21，11： | 1 |
| 4 | Competitive heterogeneous enzyme immunoassay for digoxin with electrochemical detection 显示文摘 | Hasall H B Heineaman W R | 1986 | Anal Chem1986，58，： | 1 |
| 5 | Heterogeneous EIA with Electrochemical Detection 显示文摘 | Halsall H B Heineaman W R | 1986 | Clin Chem1986，31，9： | 1 |
| 6 | Isolation, molecular charac- terization, and mapping of four rose MLO Orthologs显示文摘 | Kaufmann H Qiu X Wehmeyer J | 2012 | Frontiers in Plant Science2012，3，： | 1 |
| 7 | Energy aware compilation for DSPs with SIMD instructions显示文摘 | M Lorenz L Wehmeyer T Drger | 2002 | ACM SIGPLAN Notices2002，37，7： | 1 |
| 8 | The impact of personal characteristics of people with intellectual and developmental disability on self-determination and autonomous functioning显示文摘 | Wehmeyer ML Garner NW | | 0，，04： | 1 |
| 9 | “Saying What We do,and Doing What We Say:Implementing a Customer Service Plan”显示文摘 | Susan Wehmeyer Dorothy Auchter and Arnold Hirshon | 1996 | Journal of Academic Librarianship1996，，5： | 1 |
| 10 | The expression of small heat shock proteins in seeds responds to discrete developmental signals and suggests a general protective role in desiccation tolerance 显示文摘 | Wehmeyer N Vierling E | 2000 | Plant Physiol2000，122，： | 1 |
| 11 | Impaired os- teoclastic bone resorption leads to osteopetrosis in ca- thepsin-K-deficient mice显示文摘 | Saftig P Hunziker E Wehmeyer O | 1998 | Proc Natl Acad Sci USA1998，95，13： | 1 |
| 12 | 用于成型技术的智能夹具显示文摘技术的快速发展推动了对数字化解决方案的需求,在夹紧技术领域也是如此。那么,针对成型机的智能夹持技术蕴藏着怎样的潜力呢?由于市场对各产品种类和制造模型的需求,企业越来越关注其流程的个性化。在这一发展过程中,智能夹持技术做出了重要贡献。由于靠近工具和工件的暴露位置,夹持系统需要监控与过程相关的参数并生成重要数据。与数据分析和可视化相结合的连续状态监控能够实现更稳定、更好的可规划和可控生产。在最好的情况下,最终可以优化生产过程的效率,同时确保工件始终如一的高质量,并最大限度地缩短停机时间。 | Hendrik Bönisch Robin Kurth Klaus Wehmeyer | 2022 | 现代制造2022，，3： | 1 |
| 13 | Visualizing preference of G protein-coupled receptor kinase 3 for the process of κ-opioid receptor sequestratio显示文摘 | Wehmeyer A Schulz K | 2002 | Mol Pharmacol2002，61，： | 1 |
| 14 | Unlimited - volume electrokinetic stacking injection in sweeping capillary electrophoresis using a cationic surfactant显示文摘 | Gong M J Wehmeyer K R Limbach P A | 2006 | Anal Chem2006，978，17： | 1 |
| 15 | Human systemic exposure to [ 14 C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment显示文摘 | Gerhard J. Nohynek Julie A. Skare Wim J.A. Meuling Kenneth R. Wehmeyer Albertus Th H.J. de Bie Wouter H.J. Vaes Eric K. Dufour Rolf Fautz Winfried Steiling Mario Bramante Herve Toutain | 2015 | Food and Chemical Toxicology2015，，： | 1 |
| 16 | Dynamic adsorption of albumin on nanostructured TiO2 thin films显示文摘 | Wehmeyer JL Synowicki R Bizios R | 2010 | Mater Sci Eng C Mater Biol Appl2010，30，2： | 1 |
| 17 | Strategic channel alignment: An analysis of the confignration of physical and virtual marketing channels 显示文摘 | Muller - Lankenau C Wehmeyer K Klein S | | Information System E0，4，2： | 1 |
| 18 | Synthesis of small heat-shock protein is part of the developmental program of late seed maturation 显示文摘 | Wehmeyer N Hernandez L D Finkelstein R R | 1996 | Plant Physiology1996，112，： | 1 |
| 19 | Energy aware compilation for DSPs with SIMD instructions显示文摘 | LORENZ M WEHMEYER L DRAGER T | 2002 | ACM SIGPLAN Notices2002，37，7： | 1 |
| 20 | Self-determination and positive adult outcomes:A follow-up study of youth with mental retardation of learning disabilities显示文摘 | Schwartz M | 1997 | Exceptional Children1997，，63： | 1 |
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