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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Thrombocytopenia in patients in the medical intensive care unit:bleeding prevalence,transfusion requirements,and outcome显示文摘 | Strauss R Wehler M Mehler K | 2002 | Crit Care Med2002，30，： | 1 |
| 3 | Bioavailability and half-life of decabromodiphenyl ether (BDE-209) in rat 显示文摘 | Sandholm A Emanuelsson B M Wehler E K | 2003 | Xenobiotica2003，33，： | 1 |
| 4 | Thrombocytopenia in pa- tients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome 显示文摘 | Strauss R Wehler M Mehler K | 2002 | Crit Care Med2002，30，8： | 1 |
| 5 | Thrombocytpenia in patients in the medical intensive care unit:bleeding prevalence,transfusion requirements,and outcome显示文摘 | Strauss R Wehler M Mehler K | 2002 | Crit Care Med2002，30，8： | 1 |
| 6 | High incidence ofcataract formation after implantation of a silicone poste-rior chamber lens in phakic,highly myopic eyes 显示文摘 | Brauwriler P H Wehler T Busin M | 1999 | Ophthalmology1999，106，9： | 1 |
| 7 | Targeting the activation-in- duced antigen CD137 can selectively deplete alloreactive T ceils from antileukemic and antitumor donor T-cell lines 显示文摘 | Wehler TC Noun M Brandt B | 2007 | Blood2007，109，1： | 1 |
| 8 | Thrombocy- topenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome显示文摘 | Strauss R Wehler M Mehler K | 2002 | Crit Care Med2002，30，： | 1 |
| 9 | Thrombocytopenia in pa- tients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome 显示文摘 | Strauss R Wehler M Mehler K | 2002 | Crit Care Med2002，30，8： | 1 |
| 10 | Thrombocytopenia in patients in the medical intensive care unit:bleeding prevalence,transfusion requirements,and outcome显示文摘 | STRAUSS R WEHLER M MEHLER K | 2002 | Crit Care Med2002，30，： | 1 |
| 11 | Bioavailability and half-life of decabromodiphenyl ether (BDE-209) in rat显示文摘 | SANDHOLM A EMANUELSSON B M WEHLER E K | 2003 | Xenobiotica2003，33，11： | 1 |
| 12 | Thrombocytopenia in patientsin the medical intensive care unit: bleeding prevalence, transfusionrequirements, and outcome显示文摘 | Strauss R Wehler M Mehler K | 2002 | Crit Care Med2002，30，8： | 1 |
| 13 | Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome显示文摘 | STRAUSS R WEHLER M MEHLER K | 2002 | Crit Care Med2002，30，8： | 1 |
| 14 | Thrombocytopenia in patients in the medical intensive care unit:bleeding prevalence, transfusion requirements,and outcome 显示文摘 | Strauss R Wehler M Mehler K | 2002 | Crit Care Med2002，30，8： | 1 |
| 15 | Interventional endoscopic therapy in chronic pancreatitis including temporary stenting : a definitive treatment 显示文摘 | FARNBACHER M J MNHLDORFER S WEHLER M | 2006 | Scand J Gastroenterol2006，41，1： | 1 |
| 16 | Thrombocytopenia in patients in the medical intensive care unit: bleeding preva lence, transfusion requirements, and outcome显示文摘 | Strauss R Wehler M Mehler K | 2002 | Crit Care Med2002，30，8： | 1 |
| 17 | Thrombocytopenia in patients in the medical intensive care unit: Bleeding prevalence, transfusion requirements, and outcome 显示文摘 | Strauss R Wehler M Mehler K | 2002 | Crit Care Med2002，30，： | 1 |
| 18 | Targeting the activation- induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T- cell lines显示文摘 | Wehler TC Nonn M Brandt B | 2007 | Blood2007，109，1： | 1 |
| 19 | Genetic polymorphisms of manganese-superoxide dismutase and glutathione-S-transferase in chronic alcoholic pancreatitis 显示文摘 | OSTERREICHER C H SCHULTHEISS J WEHLER M | 2007 | Mutagenesis2007，22，5： | 1 |
| 20 | 显示文摘 | Brauweiler PH Wehler T Busin M | 1999 | Ophthalmology1999，106，9： | 1 |
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