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| 1 | Is nasopharyngeal cancer really a “Cantonese cancer”?显示文摘Nasopharyngeal cancer(NPC) is endemic in Southern China,with Guandong province and Hong Kong reporting some of the highest incidences in the world.The journal Science has called it a 'Cantonese cancer'.We propose that in fact NPC is a cancer that originated in the Bai-Yue('proto-Tai-Kadai' or 'proto-Austronesian' or 'proto-Zhuang') peoples and was transmitted to the Han Chinese in southern China through intermarriage.However,the work by John Ho raised the profile of NPC,and because of the high incidence of NPC in Hong Kong and Guangzhou,NPC became known as a Cantonese cancer.We searched historical articles,articles cited in PubMed,Google,monographs,books and Internet articles relating to genetics of the peoples with high populations of NPC.The migration history of these various peoples was extensively researched,and where possible,their genetic fingerprint identified to corroborate with historical accounts.Genetic and anthropological evidence suggest there are a lot of similarities between the Bai-Yue and the aboriginal peoples of Borneo and Northeast India;between Inuit of Greenland,Austronesian Mayalo-Polynesians of Southeast Asia and Polynesians of Oceania,suggesting some common ancestry.Genetic studies also suggest the present Cantonese,Minnans and Hakkas are probably an admixture of northern Han and southern Bai-Yue.All these populations have a high incidence of NPC.Very early contact between southern Chinese and peoples of East Africa and Arabia can also account for the intermediate incidence of NPC in these regions. | Joseph Tien Seng Wee Tam Cam Ha Susan Li Er Loong Chao-Nan Qian | 2010 | Chinese Journal of Cancer2010，29，5： | 37 |
| 2 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 3 | 黄海及周边地区α中尺度对流系统发生的环境条件显示文摘使用日本GMS - 5静止卫星红外云图普查了 1993年 7、8月份黄海及周边地区α中尺度对流系统 (MαCS)的发生情况 ,并用合成和客观分析诊断的方法考察MαCS两个活跃期和两个静寂期的大尺度环境场的热力和动力条件。结果表明 ,MαCS活跃期和静寂期的合成诊断场有显著的不同 ,从而揭示了黄海地区发生MαCS的环境条件主要为 :①低层为高相当位温的暖湿空气 ;②中低层的条件性不稳定的大气层结及暖平流 ;③强而稳定的西南低空急流 ;④低层的辐合及中层不太强的上升运动 ;⑤副热带西风急流出口区右侧的高层辐散。 | 郑永光 陶祖钰 王洪庆 Lee Dong-Kyou Wee Tae-Kwon OH Jae-Ho | 2002 | 气象学报2002，60，5： | 27 |
| 4 | 我国临终关怀准入标准界定的质性研究显示文摘目的了解临终关怀实施者、管理者及研究者对临终关怀准入的看法,界定我国临终关怀准入标准。方法采用焦点小组访谈法进行访谈,采用主题分析法整理分析资料。结果提炼出的主题有以预后为基础的准入为主,结合考虑以需求为基础的准入;增加限定条件“对临床根治治疗不获益”;可以考虑缩短准入患者预计生存期的时间;临终关怀准入应先从肿瘤患者入手;可将准入标准的评价指标细化;专业临终关怀机构可作为其他服务的中转站。结论应参考以预后为基础的准入,制定我国临终关怀准入标准。今后随着临终关怀机构的发展扩大,此标准可进一步修订。 | 周玲君 崔静 Bee Wee 赵继军 | 2010 | 中华现代护理杂志2010，16，11： | 15 |
| 5 | Associations of lifestyle and diet with the risk of nasopharyngeal carcinoma in Singapore:a case–control study显示文摘Background: Nasopharyngeal carcinoma(NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of this study was to examine associations between modifiable lifestyle factors and the risk of NPC in the Singaporean population.Methods: We conducted a case–control study in Singapore with 300 patients and 310 controls who were recruited between 2008 and 2012. Each control was selected and individually matched to each patient based on sex, ethnicity, and age(±5 years). A total of 290 pairs of cases and controls were matched successfully. We examined lifestyle factors such as tobacco smoking, alcohol drinking, various salted and preserved food consumption, and weaning practices.Results: After adjusting for covariates, multivariate analysis showed that those participants who were current smokers and had ever smoked tobacco had a higher risk of NPC than participants who had never smoked, with odds ratios(ORs) of 4.50(95% confidence interval [CI] 2.58–7.86; P < 0.001) and 2.52(95% CI 1.54–4.12; P < 0.001), respectively. Those who consumed salted vegetables at least once a week also showed a significantly increased risk of NPC than those who never or rarely consumed salted vegetables, with an OR of 4.18(95% CI 1.69–10.38; P = 0.002).Conclusion: Smoking(currently and ever-smoked) and consuming salted vegetables once a week or more were lifestyle risk factors for NPC, and changes of these factors for the better may reduce the risk of NPC. | Sook Kwin Yong Tam Cam Ha Ming Chert Richard Yeo Valerie Gaborieau James D.McKay Joseph Wee | 2017 | Chinese Journal of Cancer2017，36，2： | 12 |
| 6 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 7 | Towards Kinetic Modeling of Global Metabolic Networks: Methylobacterium extorquens AM1 Growth as Validation显示文摘Here we report a systematic method for constructing a large scale kinetic metabolic model and its initial application to the modeling of central metabolism of Methylobacterium extorquens AM1, a methylotrophic and environmental important bacterium. Its central metabolic network includes formaldehyde metabolism, serine cycle, citric acid cycle, pentose phosphate pathway, gluconeogensis, PHB synthesis and acetyl-CoA conversion pathway, respiration and energy metabolism. Through a systematic and consistent procedure of finding a set of parameters in the physiological range we overcome an outstanding difficulty in large scale kinetic modeling: the requirement for a massive number of enzymatic reaction parameters. We are able to construct the kinetic model based on general biological considerations and incomplete experimental kinetic parameters. Our method consists of the following major steps: 1) using a generic enzymatic rate equation to reduce the number of enzymatic parameters to a minimum set while still preserving their characteristics; 2) using a set of steady state fluxes and metabolite concentrations in the physiological range as the expected output steady state fluxes and metabolite concentrations for the kinetic model to restrict the parametric space of enzymatic reactions; 3) choosing enzyme constants K's and K'eqs optimized for reactions under physiological concentrations, if their experimental values are unknown; 4) for models which do not cover the entire metabolic network of the organisms, designing a dynamical exchange for the coupling between the metabolism represented in the model and the rest not included. | Ping Ao Lik Wee Lee Mary E. Lidstrom Lan Yin Xiaomei Zhu | 2008 | 生物工程学报2008，24，6： | 10 |
| 8 | 种源地对两种红树叶片结构和功能的影响:对温度的适应性遗传显示文摘植物叶片具有根据不同环境状况调整表型特征的能力,叶片性状对环境的适应能力直接影响植物在气候变化背景下的生存、分布和迁移。受全球气候变暖的影响,红树林正向高纬度地区扩张,然而关于红树植物叶片性状对不同生长地点温度变异的适应性遗传仍缺乏了解。该研究采用同质园法以来自6个不同纬度种群的木榄(Bruguiera gymnorhiza)和5个不同纬度种群的秋茄树(Kandelia obovata)幼苗为研究对象,测定了其叶片解剖结构和生理功能参数,分析红树幼苗叶片的解剖结构特征与生理功能之间的关系及对种源地温度的适应性遗传。结果发现:木榄幼苗的叶片厚度、栅栏组织和表皮厚度与种源地年平均气温均呈显著负相关关系,角质层厚度随年平均气温的升高呈下降的趋势;与木榄幼苗相比,秋茄树幼苗叶片具有较厚的表皮和角质层,较小的气孔密度和叶脉密度,叶片解剖结构未与种源地年平均气温表现出相关性。两种红树不同种源地幼苗的数据合在一起,叶片栅栏组织和海绵组织厚度均与光合速率呈正相关关系,与海绵组织厚度的相关性更强,说明叶肉组织厚度变化对红树光合作用有影响;叶脉密度与气孔密度、最大气孔导度也均呈显著正相关关系,说明两种红树在遗传适应上能够维持叶片水平的水分供需平衡。综上所述,两种红树叶片解剖结构存在差异,对种源地温度的适应性遗传有显著区别,木榄对长期生长环境形成适应性遗传;秋茄树通过建成性的叶片结构特征遗传适应种源地温度;叶片结构的差异引起了红树光合作用、最大气孔导度等生理功能发生相应的变化,从而有利于红树在气候变化的背景下得以生存和繁衍。 | 张小燕 WEE Kim Shan Alison KAJITA Tadashi 曹坤芳 | 2021 | 植物生态学报2021，45，11： | 10 |
| 9 | 心脏再同步治疗对心肌复极的影响及其潜在致心律失常作用显示文摘目的以双心室起搏为核心技术的心脏再同步治疗技术(CRT)用于治疗慢性心力衰竭(CHF)时可能引起心肌复极异常而具有潜在的致心律失常危险性。本研究以接受CRT的CHF患者为对象,观察反映心肌复极特性的心电图指标在不同部位起搏时的变化及差异,并结合患者转归探讨其意义。方法21例接受CRT和/或CRT-D治疗的CHF患者入选。在植入术过程中或者复查时,将CRT装置分别程控为右心室心内膜起搏(RV-Endo)、左心室心外膜起搏(LV-Epi)和双心室起搏(Biv),同步记录12导联心电图,测量心电图上反映复极时间和复极差异的指标QT间期、JT间期和Tp-e间期,并在不同起搏部位间比较这些参数的差异。结果准确反映心肌复极时间的JT间期和公认代表心肌跨室壁复极离散的Tp-e间期均在LV-Epi起搏时最长[(341.78±61.69)ms,(199.70±62.44)ms],Biv起搏时次之[(325.86±59.19)ms,(184.89±74.08)ms],RV-Endo起搏时最短[(286.14±38.68)ms,(146.41±31.16)ms],三者比较差异有统计学意义(P<0.0001)。QT间期的变化有类似趋势但差异无统计学意义。在(29.18±18.38)个月的随访期中,共发生4例死亡,其中1例猝死,1例发生“心律失常风暴”并最终死于无休止性室性心动过速。结论在CHF患者已有器质性心肌病变的基础上,左心室心外膜起搏和目前CRT采用的双心室起搏延长心肌复极时间并增大跨室壁心肌复极离散,从而为促进恶性心律失常的发生提供了“基质”。 | 吕家高 林立 白融 Wee Siong Teo Ruth Kam 王琳 | 2006 | 中华心律失常学杂志2006，10，2： | 10 |
| 10 | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway显示文摘 | Youjun Li Hao Zhou Fengzhi Li Siew Wee Chan Zhijie Lin Zhiyi Wei Zhou Yang Fusheng Guo Chun Jye Lim Wancai Xing Yuequan Shen Wanjin Hong Jiafu Long Mingjie Zhang | 2015 | Cell Research2015，25，7： | 9 |
| 11 | Buttress plate fixation of coronoid process fractures via a medial approach显示文摘Purpose:To assess the clinical and radiographic outcomes of coronoid process fractures surgically managed with buttress plate fixation via a medial approach.Methods:A retrospective review of all coronoid fractures surgically fixed in our institution using a buttress plate technique via a medial approach between June 2012 and April 2015 by the senior author was performed.These fractures were all sizeable fractures contributing to persistent elbow instability in terrible triad or varus posteromedial rotatory instability injury patterns.A prospective telephone questionnaire was conducted to assess patient outcomes using the disabilities of the arm,shoulder and hand(DASH)score and Mayo hlbow performance score(MEPS).Results:Twelve patients were included in the study,comprising 10 males and 2 females with an average age of 39 years(range,19-72 years).Mean follow-up was 16 months(range.4-18 months).The average time to radiographic union was 4 months(range.3-7 months).Range of motion measurements at final follow-up were obtained in 11 out of 12 patients,with one patient defaulting follow-up.All 11 patients displayed a functional elbow range of motion of at least 30°-130°.with an average arc of motion of 130°(range.110°-140°).mean elbow flexion of 134°(range.110°-140°)and mean flexion contracture of 3°(range.0°-20°).The mean DASH score was 16(range.2.5-43.8)and the mean MEPS was 75(range.65-100).Complications observed included one patient with a superfic ial wound infection which resolved with a course of oral antibiotics and one patient with radiographic evidence of heterotopic ossification which was conservatively managed.No residual elbow instability was observed and no reoperations were performed.Conclusion:Buttress plate fixation via a medial approach of coronoid process fractures that contribute to persistent elbow instability represents a reliable method of treatment that produces satisfactory and predictable outcomes. | Kelvin Kah Ho Lor Dong Hao Toon Andy Teck Huat Wee | 2019 | Chinese Journal of Traumatology2019，22，5： | 9 |
| 12 | Preparation of High Performance Foamed Concrete from Cement,Sand and Mineral Admixtures显示文摘The titled high performance foamed concrete was developed from Portland cement,ultra fine granulated blast-furnace slag,pulverized fly ash and condensed silica fume by means of pre-foaming process.The resultant foamed concrete presents its thermal conductivity of about 0.16-0.75 W/(m ℃)and 28 d compressive strength of about 1.1-23.7 MPa when its mix proportion varies in the range of cement content 280 kg-650 kg/m3,fly ash 42-97 kg/m3,slag 64-146 kg/m3,silica fume 34-78 kg/m3,and sand 0-920 kg/m3. The compressive strength of the foamed concrete with oven dried bulk density of 1500 kg/m3 in appropriate mix proportion and with small amount of superplasticizer reached as high as 44.1 MPa.Meanwhile,the fresh foamed concrete behaves like an excellent flow-ability,therefore,is especially suitable for the application in case of massive foamed concrete casting in situ and in the case of filling casting into large volume underground irregular voids,except for pre-casting of building components like blocks,bricks,and wall panels. | 潘志华 Fujiwara Hiromi Wee Tionghuan | 2007 | Journal of Wuhan University of Technology(Materials Science)2007，22，2： | 8 |
| 13 | 自行车通勤方式文献综述显示文摘无论对通勤者个人还是整个社会,自行车通勤方式要优于其他出行方式。尽管如此,很大一部分通勤者还是放弃了自行车方式。为巩固自行车通勤激励政策的理论基础,研究了影响人们选择自行车通勤方式的决定因素;由于许多自行车通勤者并不是每天都骑车上下班,所以也考虑了其日常出行方式选择情况,以使用频率表示。为明确上述决定因素对自行车通勤的影响,对现有文献进行了广泛研究,发现现有文献对许多决定因素的阐述,并未遵循出行方式选择的传统研究方法及模型,这表明对自行车使用的影响与预测还应以其他知识为基础,而不仅仅是现有的机动车交通模型。 | Eva Heinen Bert van Wee Kees Maat 高海欣 马祥禄 | 2011 | 城市交通2011，9，2： | 8 |
| 14 | R507A,R404A与R22在低温冷冻工况下的性能比较显示文摘对R507A,R404A及R22在低温冷冻应用中进行理论性能分析。R22是纯工质制冷剂,泄漏-充注次数对机组性能没有影响。而R507A与R404A为混合工质,在5次泄漏-充注后,R507A的容积制冷量基本不变,而R404A的容积制冷量降低1.6%左右。在相同压缩机及相同运行工况下,R507A机组的制冷量比R22机组大7%~13%,R404A机组的制冷量比R22机组大4%~10%左右。在环境温度较高时,R22机组的效率略高于R507A与R404A;环境温度较低时,R507A与R404A机组的效率比R22略高。 | 卢智利 Chin Soon wee 孙蔼军 李梦玲 曹霞 徐巍 莫浩成 胡炎钧 | 2008 | 制冷与空调2008，8，B06： | 8 |
| 15 | P2P信息检索及其优化策略显示文摘本文研究对等计算(P2P)环境中语义丰富的信息检索及其优化策略,提出了P2P信息检索系统(PIRS),实现了P2P环境中语义丰富的信息检索,定义了一套评价PIRS效率的指标体系;明确了决定PIRS效率的关键因素并提出相应的解决策略,包括:基于向量空间模型的节点数据分类管理策略、基于节点聚类的系统数据管理策略以及自适应查询路由策略,并用实验结果验证了这些策略的有效性。 | 凌波 吕永成 周水庚 周傲英 Ng Wee Siong | 2006 | 计算机科学2006，33，8： | 8 |
| 16 | Whole-genome sequencing to detect mutations associated with resistance to insecticides and Bt proteins in Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a major pest native to the Americas that has recently invaded the Old World.Point mutations in the target-site proteins acetylcholinesterase-1(ace-1),voltage-gated sodium channel(VGSC)and ryanodine receptor(RyR)have been identified in S.frugiperda as major resistance mechanisms to organophosphate,pyrethroid and diamide insecticides respectively.Mutations in the adenosine triphosphate-binding cassette transporter C2 gene(ABCC2)have also been identified to confer resistance to Cry IF protein.In this study,we applied a whole-genome sequencing(WGS)approach to identify point mutations in the target-site genes in 150 FAW individuals collected from China,Malawi,Uganda and Brazil.This approach revealed three amino acid substitutions(A201S,G227A and F290V)of S.frugiperda ace-1,which are known to be associated with organophosphate resistance.The Brazilian population had all three ace-1 point mutations and the 227A allele(mean frequency=0.54)was the most common.Populations from China,Malawi and Uganda harbored two of the three ace-1 point mutations(A201S and F290V)with the 290V allele(0.47-0.58)as the dominant allele.Point mutations in VGSC(T929I,L932F and L1014F)and RyR(I4790M and G4946E)were not detected in any of the 150 individuals.A novel 12-bp insertion mutation in exon 15 of the ABCC2 gene was identified in some of the Brazilian individuals but absent in the invasive populations.Our results not only demonstrate robustness of the WGS-based genomic approach for detection of resistance mutations,but also provide insights for improvement of resistance management tactics in S.frugiperda. | Fang Guan Jianpeng Zhang Huiwen Shen Xingliang Wang Amanda Padovan Tom K.Walsh Wee Tek Tay Karl H.J.Gordon William James Cecilia Czepak Michael Hilary Otim Donald Kachigamba Yidong Wu | 2021 | Insect Science2021，28，3： | 6 |
| 17 | Comparison of two Nd:YAG laser posterior capsulotomy: cruciate pattern vs circular pattern with vitreous strand cutting显示文摘AIM: To investigate the effects and safety of neodymium: yttrium-aluminium-garnet(Nd:YAG) laser posterior capsulotomy with vitreous strand cuttingMETHODS: A total of 40 eyes of 37 patients with symptomatic posterior capsular opacity(PCO) were included in this prospective randomized study and were randomly subjected to either cruciate pattern or round pattern Nd:YAG posterior capsulotomy with vitreous strand cutting(modified round pattern). The best corrected visual acuity(BCVA), intraocular pressure(IOP), refractive error, endothelial cell count(ECC), anterior segment parameters, including anterior chamber depth(ACD) and anterior chamber angle(ACA) were measured before and 1 mo after the laser posterior capsulotomy. RESULTS: In both groups, the BCVA improved significantly(P<0.001 for the modified round pattern group, P=0.001 for the cruciate pattern group); the IOP and ECC did not significantly change. The ACD significantly decreased(P<0.001 for both) and the ACA significantly increased(P=0.001 for the modified round pattern group and P=0.034 for the cruciate group). The extent of changes in these parameters was not significantly different between the groups.CONCLUSION: Modified round pattern Nd:YAG laser posterior capsulotomy is an effective and safe method for the treatment of PCO. This method significantly changes the ACD and ACA, but the change in refraction is not significant. Modified round pattern Nd:YAG laser posterior capsulotomy can be considered a good alternative procedure in patients with symptomatic PCO. | Jin-Soo Kim Jung Yeol Choi Ji-Won Kwon Won Ryang Wee Young Keun Han | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 6 |
| 18 | 两种红树植物不同种源幼苗对模拟高温热浪的光合生理响应差异显示文摘以来自中国广西(较低纬度)和日本冲绳(较高纬度)两个地理种群的耐冷秋茄(Kandelia obovata Sheue,H.Y.Liu&J.Yong)和耐热木榄(Bruguiera gymnorrhiza(L.)Savigny)为材料,测定其光系统Ⅰ(PSⅠ)和光系统Ⅱ(PSⅡ)活性参数、叶黄素循环组分和叶绿素a、b的含量,并分析他们经高温处理后光合生理响应的差异。结果显示:高温处理使植物PSⅡ最大光化学潜能(F v/F m)显著降低,降低幅度为较低纬度种群<较高纬度种群、木榄幼苗<秋茄幼苗;P700氧化还原状态(P m)降低,降低幅度为较低纬度种群<较高纬度种群;叶片非光化学猝灭(NPQ)升高,表现为较低纬度种群>较高纬度种群、木榄幼苗>秋茄幼苗。高温处理引起叶黄素库容量(V+A+Z)和脱环氧化状态(A+Z)/(V+A+Z)升高,表现为较低纬度种群>较高纬度种群;(A+Z)/(V+A+Z)与F v/F m负相关,而与NPQ正相关。常温恢复第2 d,高纬度种源秋茄幼苗F v/F m仍为0.69,表明其PSⅡ受到不可逆的损伤,而其余种源幼苗的F v/F m均恢复到正常水平,且所有种源幼苗仍保持较高的NPQ以及叶黄素脱环氧化比率,起光保护作用。与萨瓦纳和地中海型生境相比,红树林有最大的叶黄素库。研究结果表明,低纬度种群对高温胁迫具有较高的适应性,部分原因是叶黄素循环具有较强的光保护作用,物种及种源间存在耐冷和耐热性的权衡。 | 张小燕 Alison Kim Shan Wee Tadashi Kajita 朱俊杰 曹坤芳 | 2021 | 植物科学学报2021，39，4： | 6 |
| 19 | Focus on the gut-brain axis: multiple sclerosis, the intestinal barrier and the microbiome显示文摘The brain-gut axis serves as the bidirectional connection between the gut microbiome, the intestinal barrier and the immune system that might be relevant for the pathophysiology of inflammatory demyelinating diseases. People with multiple sclerosis have been shown to have an altered microbiome, increased intestinal permeability and changes in bile acid metabolism. Experimental evidence suggests that these changes can lead to profound alterations of peripheral and central nervous system immune regulation. Besides being of pathophysiological interest, the brain-gut axis could also open new avenues of therapeutic targets. Modification of the microbiome, the use of probiotics, fecal microbiota transplantation, supplementation with bile acids and intestinal barrier enhancers are all promising candidates. Hopefully, pre-clinical studies and clinical trials will soon yield significant results. | Carlos R Camara-Lemarroy Luanne M Metz V Wee Yong | 2018 | World Journal of Gastroenterology2018，24，37： | 6 |
| 20 | Is there an association between Helicobacter pylori infection and irritable bowel syndrome? A meta-analysis显示文摘BACKGROUND Irritable bowel syndrome(IBS)is a prevalent and debilitating gastrointestinal condition.Research has reported persistent,low-grade mucosal inflammation and significant overlaps between patients with IBS and those with dyspepsia,suggesting a possible pathogenic role of Helicobacter pylori(H.pylori)in IBS.This study therefore aimed to provide the first systematic review and meta-analysis on the association between H.pylori infection and IBS.AIM To investigate the association between H.pylori infection and IBS.METHODS Using the keywords“H.pylori OR Helicobacter OR Helicobacter pylori OR infection”AND“irritable bowel syndrome OR IBS”,a preliminary search of PubMed,Medline,Embase,Cochrane Database of Systematic Reviews,Web of Science,Google Scholar and WanFang databases yielded 2924 papers published in English between 1 January 1960 and 1 June 2018.Attempts were also made to search grey literature.RESULTS A total of 13 clinical studies were systematically reviewed and nine studies were included in the final meta-analysis.Random-effects meta-analysis found a slight increased likelihood of H.pylori infection in patients with IBS,albeit this was not statistically significant(pooled odds ratio 1.47,95%confidence interval:0.90-2.40,P=0.123).It must also be acknowledged that all of the available studies reported only crude odd ratios.H.pylori eradication therapy also does not appear to improve IBS symptoms.Although publication bias was not observed in the funnel plot,there was a high degree of heterogeneity amongst the studies included in the meta-analysis(I2=87.38%).CONCLUSION Overall,current evidence does not support an association between IBS and H.pylori infection.Further rigorous and detailed studies with larger sample sizes and after H.pylori eradication therapy are warranted. | Qin Xiang Ng Nadine Xinhui Foo Wayren Loke Yun Qing Koh Vanessa Jing Min Seah Alex Yu Sen Soh Wee Song Yeo | 2019 | World Journal of Gastroenterology2019，25，37： | 5 |
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