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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 4 | Direct measurement of drainage curves in infiltration of SiC particle preforms显示文摘 | BAHRAINI M MOLINA J M WEBER L | 2008 | Materials Science and Engineering:A2008，495，12： | 1 |
| 5 | Shorebird diet and size selection of nereid polychaetes in South Carolina coastal diked wetlands 显示文摘 | WEBER L M HAIG S M | 1997 | Journal of Field Ornithology1997，68，3： | 1 |
| 6 | Interface formation in infiltrated AI (Si)/diamond composites 显示文摘 | BEFFORT O KHALID F A WEBER L | 2006 | Diamond and Related Materials2006，15，9： | 1 |
| 7 | Sublethal toxicity of two wastewater treatment polymers to lake trout fry (Salvelinus namaycush ) 显示文摘 | Liber K Weber L Levesque C | 2005 | Chemosphere2005，61，8： | 1 |
| 8 | Categorization of Scope 3 Emissions for Streamlined Enterprise Carbon Footprinting 显示文摘 | Huang Y A Weber C L Matthews H S | 2009 | Environmental Science & Technology2009，43，22： | 1 |
| 9 | Morphine induces mesangial cell proliferation and glomerulopathy via kappa-opioid receptors显示文摘 | WEBER M L FAROOQUI M NGUYEN J | 2008 | Am J PhysioI Renal Physiol2008，294，6： | 1 |
| 10 | Effect of the endothelin receptor antagonist bosentan on the pharmacokinetics and pharmacodynamics of wargarin显示文摘 | Weber C Banken L Birnboeck H | 1999 | J Clin Phannacol1999，39，： | 1 |
| 11 | Ocean Surface Currents Mapped by Radar显示文摘 | Barrick D E Evans M W Weber B L | 1977 | Science1977，198，： | 1 |
| 12 | Anobjective time-integration procedure for isotropic rate-independentand rate-dependent elastic-plastic constitutive equations 显示文摘 | WEBER G G LUSH A M ZAVALIANGOS-A ANAND L | 1990 | Int JPlasticity1990，6，： | 1 |
| 13 | Markets for water rights under environmental constraints 显示文摘 | Weber L | 2001 | Journal of Environmental Economics and Management2001，42，1： | 1 |
| 14 | Embodied environment emissions in U S international trade: 1997-2004 显示文摘 | Weber C L Matthews H S | 2007 | Environmental Science and Technology2007，41，14： | 1 |
| 15 | Neutrophil gra-nule proteins tune monocytic cell function 显示文摘 | Soehnlein 0 Weber C Lindbom L | 2009 | TrendsImmunol2009，30，11： | 1 |
| 16 | A Directional Slacks-based Measure of Technical Inefficiency 显示文摘 | Fukuyama H Weber W L | 2009 | Socio-Economic Planning Sciences2009，43，4： | 1 |
| 17 | Embodied environmental emissions in US international trade, 1997-2004 显示文摘 | Weber C L Matthews H S | 2007 | Environmental Science & Technology2007，41，14： | 1 |
| 18 | Advances in imaging secondary ion mass spectrometry for biological samples显示文摘 | Boxer S G Kraft M L Weber P K | | 0，，： | 1 |
| 19 | Reanalysis of a ran- domized trial of 3 techniques of anterior eolporrhaphy using clinically relevant definitions of success 显示文摘 | Chnfielewski L Waiters MD Weber AM | 2011 | Am J Obstet Gynecol2011，205，1： | 1 |
| 20 | New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents wogonin,baicalein and baicalin 显示文摘 | Weber M L | 2009 | Canc- er Treat Rev2009，35，1： | 1 |
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