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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016，8，10： | 5 |
| 3 | Clostridium difficile Enteritis after Colectomy显示文摘 | Causey M Wayne Spencer Michael P Steele Scott R | 2009 | The American Surgeon2009，，12： | 2 |
| 4 | Colometer:A real-time quality feedback system for screening colonoscopy显示文摘AIM:To investigate the performance of a new software-based colonoscopy quality assessment system.METHODS:The software-based system employs a novel image processing algorithm which detects the levels of image clarity,withdrawal velocity,and level of the bowel preparation in a real-time fashion from live video signal.Threshold levels of image blurriness and the withdrawal velocity below which the visualization could be considered adequate have initially been determined arbitrarily by review of sample colonoscopy videos by two experienced endoscopists.Subsequently,an overall colonoscopy quality rating was computed based on the percentage of the withdrawal time with adequate visualization(scored 1-5;1,when the percentage was 1%-20%;2,when the percentage was 21%-40%,etc.).In order to test the proposed velocity and blurriness thresholds,screening colonoscopy withdrawal videos from a specialized ambulatory colon cancer screening center were collected,automatically processed and rated.Quality ratings on the withdrawal were compared to the insertion in the same patients.Then,3 experienced endoscopists reviewed the collected videos in a blinded fashion and rated the overall quality of each withdrawal(scored 1-5;1,poor;3,average;5,excellent) based on 3 major aspects:image quality,colon preparation,and withdrawal velocity.The automated quality ratings were compared to the averaged endoscopist quality ratings using Spearman correlation coefficient.RESULTS:Fourteen screening colonoscopies were assessed.Adenomatous polyps were detected in 4/14(29%) of the collected colonoscopy video samples.As a proof of concept,the Colometer software rated colonoscope withdrawal as having better visualization than the insertion in the 10 videos which did not have any polyps(average percent time with adequate visualization:79% ± 5% for withdrawal and 50% ± 14% for insertion,P < 0.01).Withdrawal times during which no polyps were removed ranged from 4-12 min.The median quality rating from the automated system and the reviewers was 3.45 [interquartile range(IQR),3.1-3.68] and 3.00(IQR,2.33-3.67) respectively for all colonoscopy video samples.The automated rating revealed a strong correlation with the reviewer's rating(ρ coefficient= 0.65,P = 0.01).There was good correlation of the automated overall quality rating and the mean endoscopist withdrawal speed rating(Spearman r coefficient= 0.59,P = 0.03).There was no correlation of automated overall quality rating with mean endoscopists image quality rating(Spearman r coefficient= 0.41,P = 0.15).CONCLUSION:The results from a novel automated real-time colonoscopy quality feedback system strongly agreed with the endoscopists' quality assessments.Further study is required to validate this approach. | Dobromir Filip Xuexin Gao Leticia Angulo-Rodriguez Martin P Mintchev Shane M Devlin Alaa Rostom Wayne Rosen Christopher N Andrews | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 5 | Characterization of spermidine hydroxycinnamoyl transferases from eggplant (Solanum melongena L.) and its wild relative Solanum richardii Dunal显示文摘Eggplant produces a variety of hydroxycinnamic acid amides(HCAAs)that have an important role in plant development and adaptation to environmental changes.In this study,we identified and characterized a spermidine hydroxycinnamoyl transferase(SHT)from eggplant(Solanum melongena)and its wild relative S.richardii,designated as SmSHT and SrSHT,respectively.SmSHT was abundant in flowers and fruits,whereas the level of SrSHT was remarkably low in all tissues.Heat-shock/drought treatment stimulated the expression of SmSHT in both leaves and fruits,indicating its involvement in plant stress response.Both SHT polypeptides had extremely high identity with just five amino-acid substitutions.Recombinant SmSHT catalyzed the synthesis of mono-,bi-and tri-acylated polyamines.Using caffeoyl-CoA as the acyl donor,SmSHT preferred spermidine as the acyl acceptor.When spermidine was the acyl acceptor,the donor preference order for SmSHT was caffeoyl-CoA>feruloyl-CoA>ρ-coumaroyl-CoA.SrSHT exhibited the same substrate specificity as SmSHT,yet exhibited significantly higher catalytic activity than SmSHT.For example,under caffeoyl-CoA and spermidine,Kcat of SrSHT was 37.3%higher than SmSHT.Molecular modeling suggests that five amino-acid substitutions in SrSHT result in four alterations in their predicted 3D structures.In particular,the conserved Lys402 adjacent to the DFGWG motif,and Cys200 in the crossover loop in SmSHT were replaced by Glu and Ser in SrSHT.These substitutions may contribute to the enhanced activity in SrSHT.Our study provides a platform to generate HCAA rich fruits for eggplant and other solanaceous crops. | Hui Peng Tianbao Yang Bruce D Whitaker Frances Trouth Lingfei Shangguan Wen Dong Wayne M Jurick | 2016 | Horticulture Research2016，3，1： | 2 |
| 6 | Processing Molten Aluminum-Part2:Cleaning Up Your Metal显示文摘 | David P Wayne M | 1990 | Modern casting1990，，2： | 1 |
| 7 | Microsatellites and their application to population genetic studies显示文摘 | BRUFORD M W WAYNE R K | 1993 | Current Opinion in Genetics and Development1993，3，： | 1 |
| 8 | Leader-Member Exchange, Differentiation, and Psychological Contract Fulfillment: A Multilevel Examination 显示文摘 | HENDERSON D J WAYNE S J SHORE L M | 2008 | Journal of Applied Psychology2008，93，6： | 1 |
| 9 | An examination of per- ceived organizational support as a multidimensional construct in the context of an expatriate assign- ment显示文摘 | Kraimer M L Wayne S J | 2004 | Journal of Management2004，30，2： | 1 |
| 10 | Iliac vein compression syndrome : a new method of treatment 显示文摘 | Baron HC Shams J Wayne M | 2000 | Am Surg2000，66，： | 1 |
| 11 | Commitment and employee behavior:Comparison of affective commitment and continuance commitment with perceived organizational support显示文摘 | Shore L M Wayne S J | 1993 | Journal of Applied Psychology1993，78，5： | 1 |
| 12 | Modified Starch-based Biodegradable Particles 显示文摘 | Wayne J Maddever Graham M Chapman | 1989 | Plastics Engineering1989，45，7： | 1 |
| 13 | Treatment of severe chronic venous insufficiency using the subfascial endoscopic perforator vein procedure显示文摘 | Baron H G Wayne M G Santiago C | 2005 | Surg Endosc2005，19，1： | 1 |
| 14 | Commitment and Employee Behavior:Comparison of Affective Commitment and Continuance Commitment with Perceived Organizational Support 显示文摘 | Shore L M Wayne S J | 1993 | Journal of Applied Psychology1993，78，5： | 1 |
| 15 | Radiation-induced epigenetic DNA methylation modification of radiation-response pathways显示文摘 | Deborah A Antwih Kristina M Gabbara Wayne D Lancaster Douglas M Ruden Steven P Zielske | 2013 | Epigenetics2013，，8： | 1 |
| 16 | Treatment of severe chronic venous insufficiency using the subfascial endoscopic perforator vein procedure 显示文摘 | BARON H C WAYNE M G SANTIAGO C A | 2005 | Surg Endosc2005，19，1： | 1 |
| 17 | Stop hypertension with the acupuncture research program (SHARP): results of a randomized, controlled clinical trial 显示文摘 | MACKLIN E A WAYNE P M KALISH L A | 2006 | Hypertension2006，48，5： | 1 |
| 18 | Orientation of silk Ⅲat the air-water interface显示文摘 | Regina V Samuel P Wayne M | 1999 | International Journal of Biological Macromolecules1999，24，2： | 1 |
| 19 | Chemical Oxygen Demand Analysis of Waste Water Using Trivalent Mangunese Oxidant with Chloride Removal by Sodium Bismuthate Pretreatment显示文摘 | DONALD G M SCOTT V B WAYNE T B | 2001 | Water Environment Research2001，73，1： | 1 |
| 20 | Tai Chi exercise in patients with chronic heart failure显示文摘 | YEH G Y WAYNE P M PHILLIPS R S | 2008 | Med Sport Sci2008，52，： | 1 |
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