|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 手术期间化学疗法与单独手术治疗可切除的胃食管癌疗效比较显示文摘 | Cunningham D Allum WH Stenning SP 菅鑫妍 | 2006 | 中国处方药2006，5，8： | 432 |
| 2 | Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016显示文摘Portal vein tumor thrombosis(PVTT) is a common phenomenon in hepatocellular carcinoma(HCC). Compared to HCC without PVTT, HCC with PVTT is characterized by an aggressive disease course, worse hepatic function, a higher chance of complications related to portal hypertension and poorer tolerance to treatment. Conventionally, HCC with PVTT is grouped together with metastatic HCC during the planning of its management, and most patients are offered palliative treatment with sorafenib or other systemic agents. As a result, most data on the management of HCC with PVTT comes from subgroup analyses or retrospective series. In the past few years, there have been several updates on management of HCC with PVTT. First, it is evident that HCC with PVTT consists of heterogeneous subgroups with different prognoses. Different classifications have been proposed to stage the degree of portal vein invasion/thrombosis, suggesting that different treatment modalities may be individualized to patients with different risks. Second, more studies indicate that more aggressive treatment, including surgical resection or locoregional treatment, may benefit select HCC patients with PVTT. In this review, we aim to discussthe recent conceptual changes and summarize the data on the management of HCC with PVTT. | Stephen L Chan Charing CN Chong Anthony WH Chan Darren MC Poon Kenneth SH Chok | 2016 | World Journal of Gastroenterology2016，22，32： | 44 |
| 3 | Mouse models in liver cancer research:A review of current literature显示文摘Primary liver cancer remains one of the most lethal malignancies worldwide. Due to differences in prevalence of etiological factors the incidence of primary liver can-cer varies among the world, with a peak in East-Asia. As this disease is still lethal in most of the cases, research has to be done to improve our understanding of the disease, offering insights for possible treatment options. For this purpose, animal models are widely used, especially mouse models. In this review, we describe the different types of mouse models used in liver cancer research, with emphasis on genetically engineered mice used in this field. We focus on hepatocellular carcinoma (HCC), as this is by far the most common type of primary liver cancer, accounting for 70%-85% of cases. | Martijn WH Leenders Maarten W Nijkamp Inne HM Borel Rinkes | 2008 | World Journal of Gastroenterology2008，14，45： | 16 |
| 4 | 外科手术中血液回输在医学界的争论显示文摘1886年首次报导手术中血液的利用(IBS)和自身输血。随着现代化心血管、创伤外科的发展,它的应用明显增多。近20年在这个领域中有许多文献。并存在着争论。作者复习了有关IBS应用的指征、反指征和并发症方面的主要文献,不加评价,以了解IBS的应用尚需进一步研究。本文所指的手术中血液利用(TBS),不包括术中血液稀释和输预先贮存的自体血。肿瘤外科在IBS时获得的肿瘤细胞有回输造成肿瘤转移的可能,所以原发的,没有转移的恶性肿瘤切除作IBS和自体输血是禁忌的;已确定有转移的作姑息性肿瘤切除者更不用IBS。 | Dzik WH 周惠玲 贺明琪 | 1991 | 国外医学(输血及血液学分册)1991，14，6： | 12 |
| 5 | Symptom clusters and quality of life among patients with advanced heart failure显示文摘ObjectivesTo 与先进的心失败(HF ) 和与他们 .MethodsThis 是的生活(QoL ) 的质量的独立关系在病人之中识别症状簇会见了 119 个病人与的代表性的研究的第二等的数据分析在香港在一所地区性的医院的衰老老人单位推进了 HF。症状侧面和 QoL 被使用埃德蒙顿症状评价规模(ESAS ) 和 McGill QoL 问询表估计。探索因素分析被用来识别症状簇。层次回归分析被用来与他们的 QoL 检验独立关系,在调整病人们在先进年龄的年龄,性,和 comorbidities.ResultsThe 的效果以后(82.9 ±6.5 年) 。三不同症状簇被识别:他们是悲痛簇(呼吸,焦虑,和消沉的包括的短小) , decondition 簇(疲劳,睡意,恶心,和减少的胃口) ,和不快聚类(概括不快的疼痛,和感觉) 。这三症状簇说明了病人症状经验的 63.25% 变化。对在这些症状簇之间的中等关联小显示他们是独立人士互相。在调整年龄,性和 comorbidities 以后,悲痛(β=− 0.635, P <0.001 ) , decondition (β=− 0.148, P = 0.01 ) ,并且不快(β=− 0.258, P <0.001 ) 症状簇独立地预言他们的 QoL.ConclusionsThis 学习与先进 HF 在病人之中识别了特殊症状簇。结果使需要清楚些为为这限制生活的疾病优化症状控制开发辩解的照顾干预。 | Doris SF Yu Helen YL Chan Doris YP Leung Elsie Hui Janet WH Sit | 2016 | Journal of Geriatric Cardiology2016，13，5： | 12 |
| 6 | In vitro and in vivo effects of hydrolysates from conglycinin on intestinal microbial community of mice after Escherichia coli infection显示文摘 | Shen CL Chen WH Zou SX | 2007 | 中国生物学文摘2007，21，7： | 7 |
| 7 | 钢在海水中的阴极极化特点及阴极保护系统设计的新途径显示文摘实验表明对于海水中实验阴极保护的钢材,其阴极电位与电流密度的线性关系随时间的衰减用“斜率”来表示,此斜率是阴极表面积和电路总电阻的倍数,并且将直线外推与纵轴的交点是阳极腐蚀电位。 | 陈绍伟 HARTT,WH | 1996 | 腐蚀科学与防护技术1996，8，1： | 6 |
| 8 | Carbide Behavior during High Temperature Creep in DZ40M Co-base Superalloy显示文摘The carbide behavior of a directionalIy solidified Co-base superalloy DZ40M has been investigatedafter creep at 700° and 900°. During the high temperature creep, a great amount of secondary carbide, M3C6 precipitated in alloy matrix. At 700℃, the M23C6 precipitation occurred in slip bands, indicating that it was stress-induced, while at 900℃, M23C6 formed surrounding the primary carbides, which is a characteristic of thermally aged alloy. The M23C6 particles pinned up dislocations and subgrain boundaries, strengthening the alloy matrix effectively. The creep crack initiation of DZ40M alloy was exclusively related to the primary carbides. The fracture of the primary carbide and the crack at the interface between them and matrix resulted in the crack formation. Furthermore, it was found that at 900℃, the surface of specimens was oxidized severely and the preferentially oxidized primary carbides acted as crack initiation sites. | Jiang, WH Yao, XD Guan, HR Hu, ZQ | 1999 | Journal of Materials Science & Technology1999，15，6： | 6 |
| 9 | 血液及体液溅落物在大型教学医院中的分布调查显示文摘血液和体液的溅落(BBFSs)是潜在的感染源。但它在医院中的分布却从未有人描述过。我们在香港玛丽皇后医院就此进行了一次流行状况调查。在调查的第一阶段,我们调查了当班护士以肯定BBFSs已被医院中的勤杂人员加以清除,在第二阶段,我们对227位勤杂人员进行了提问,以确定在他们上班时发生BBFSs的次数、类型和原因。据报告,在手术室及急诊室出现了130例溅落,其中大部分是血液(分别为82%及60%)。在病房中出现的518例溅落中,38%为尿液,26%为血液,13%为痰液,9%为呕吐物,8%为粪便,4%为脓液或引流液,4%为透析液,溅落平均发生频度为40次/100张床/日。血液出现频度最高处为ICU(25次/100张床),尿液出现频度最高处为大学部内科和骨科,(27次/100张床),痰液出现频度最高处为内科(14次/100张床),粪便出现频度最高处为骨科(7次/100张床),呕吐物出现频度最高处为儿科(8次/100张床),据报告,80%的溅落是病人引起的。 | Scto WH Ching TY Yucn KY Chu YB 艾成绪 | 1991 | 中华医院感染学杂志1991，1，1： | 5 |
| 10 | Survival factors after resection of small hepatocellular carcinoma显示文摘Early resection of hepatocellular carcinoma is a key measure to prolong the survival of patients. This study was designed to summarize our experience in surgical resection of small hepatocellular carcinoma (HCC), and to analyze the factors influencing the postoperative survival of patients. METHODS:The clinicopathologic data of 105 patients with small HCC after resection from 1986 through 2003 were analyzed ; the patients had been followed up for more than half a year (median 33 months). Nine clinicopathologic factors, preoperative α-fetoprotein (AFP) level, liver cirrhosis, Child-Pugh score, tumor size (>2cm vs.≤2 cm) and number (single vs. multiple), capsule formation, portal vein tumor thrombi (PVTT), Edmondson tumor grade and surgical method, were analyzed by the log-rank test and the Cox proportional harzards model analysis. RESULTS:The cumulative 1-,3- and 5-year survival rates after the operation were 86.5%, 70.3% and 55.2%, respectively, and the 1-, 3- and 5-year disease-free survival rates were 78%, 58. 9% and 45. 6%, respectively. One patient died from esophagogastric varices hemorrhage in 2 weeks after reoperation. Thirty-six patients had intrahepatic recurrence or metastasis postoperatively and 34 patients died. The Kaplan-Meier method and the Cox proportional harzards model analysis indicated that poor Child-Pugh score, tumor more than 2 cm in diameter, PVTT and multiple lesions (including satellitic lesions) were adverse factors affecting postoperative survival. The Cox proportional harzards model analysis indicated that tumor size, PVTT and multiple lesions were the factors influencing postoperative disease-free survival. CONCLUSIONS:Limited hepatectomy with a margin more than 1 cm is an appropriate surgical approach. Adverse preoperative Child-Pugh score and postoperative intrahepatic recurrences are the main factors leading to the death of patients with small HCC. | Departments of Surgical Oncology (Wu FS, Zhao WH, Ma ZM, Teng LS and Wang M) and General Surgery ( Liang TB and Zheng SS) , First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 5 |
| 11 | Effects of a nurse-led heart failure clinic on hospital readmission and mortality in Hong Kong显示文摘 | Ho Yu Cheng Sek Ying Chair Qun Wang Janet WH Sit Eliza ML Wong Siu Wai Tang | 2016 | Journal of Geriatric Cardiology2016，13，5： | 5 |
| 12 | Off-pump coronary artery bypass grafting versus optimal medical therapy alone:effectiveness of incomplete revascularization in high risk patients显示文摘有 multivessel 的 BackgroundGeriatric 病人冠的动脉疾病(CAD ) 是一个挑战性的组对待;这些盒子关于在这些病人上并且经常承担主要外科的实际利益在心队以内得到讨论导致放纵外科的选择。经皮的过程代表一种重要选择,但是冠的解剖可能是相反的。离开泵冠的动脉绕过(OPCAB ) 提供好质量没有暴露病人到的左前面的下降上的接枝(男孩) 心肺绕过,并且可能是在有多重 comorbidities 的病人的理想的选择,不是对合格经皮或在泵上过程。这研究的目的是没有经皮的选择在高风险的病人在中间的后续期间比较幸存,也与 OPCAB 对待或在回顾地从 2008 年 6 月评估到 2013 年 6 月的医药 therapy.MethodsWe 排出,有 multivessel CAD 的 83 个高风险的病人被包括:42 在男孩上用左内部乳房的动脉(LIMA ) 与不完全的离开泵 revascularization 被对待;41 在最佳的医药治疗(OMT ) 被解除,拒绝了外科。后续在 2015 年 3 月结束了,与一电话的会见。主要端点是从所有原因死亡的幸存;第二等的端点从非致命的主要不利心脏的事件(权标) 是从心脏相关的死亡和自由的幸存 .ResultsDuring 列在后面在上面,在 OPCAB 组的 11 死亡和在 OMT 组的 27 死亡发生了。死亡分别地由于在 6 和 15 个病人的心脏的因素。权标在 OMT 组在 OPCAB 组并且在 4 个病人在 6 个病人被观察。关于从所有原因死亡的幸存,经历了多于那些熬过的 OPCAB 的病人在 OMT 排出(木头等级 <0.001 ) ,并且 OMT 组带倾向 3.862 的调整分数的危险比率(P <0.001 ) 。关于从心脏相关的事件的幸存,经历了多于那些熬过的 OPCAB 的病人在 OMT 排出(木头等级 = 0.002 ) ,并且 OMT 组带倾向 3.663 的调整分数的危险比率(P = 0.010 ) 。有关从权标的自由没有统计上重要的差别(木头等级 = 0.273 ).ConclusionsFor 有 multivessel CAD 的高风险的病人,不是对在泵上合格完全的 revascularization 外科或经皮的过程,有 OPCAB LIMA-on-LAD 提议的不完全的 revascularization 在幸存受益什么时候与 OMT 相比独自一个。 | Filippo Prestipino Cristiano Spadaccio Antonio Nenna Fraser WH Sutherland Gwyn W Beattie Mario Lusini Francesco Nappi Massimo Chello | 2016 | Journal of Geriatric Cardiology2016，13，1： | 4 |
| 13 | Phase Evolution during the Sintering of Submicron Ti(C,N)-Based Cermets显示文摘The submicron powder mixtures of TiC-TiN-WC-Mo-C-Ni sintered at 1400℃ or below in vacuum were studied by X-ray diffration (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses. The results showed that Mo2C fOrmed at 800℃ or below. Both WC and Mo2C disappeared at 1200 ℃, and TiN disappeared at 1250℃. In addihon, the variahons of lanice constans of the htanium carbonitride and nickel binder phase with sintering temperature were experimentally obtained, and the reason was analyzed. | Li, CH Xiong, WH Yu, LX | 2001 | Rare Metals2001，20，4： | 4 |
| 14 | 社区人群血压和颈动脉血流速度与脑容量和脑小血管病的关系显示文摘做脑磁共振成像(magnetic resonance imaging,MRI)经常发现脑小血管病(cerebral small vessel disease,CSVD)。研究已证明高血压和低颈动脉血流速度与脑血管病存在关联。但是,这种关联与脑容量和CSVD的相关性仍有待研究。本文纳入基于社区的I-Lan纵向衰老研究(I-Lan longitudinal aging study)中年龄≥50岁的成年人721例进行分析,采用多普勒超声测量颈总动脉和颈内动脉血流速度,包括收缩期峰值血流速度(peak systolic velocity,PSV)和舒张终末期血流速度(end-diastolic velocity,EDV)。 | 袁源(摘译) 郑武洪(审校) Chuang SY Wang PN Chen LK Chou KH Chung CP Chen CH Mitchell GF Pan WH Cheng HM | 2021 | 中华高血压杂志2021，29，9： | 4 |
| 15 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 16 | Slower cycling of nestin-positive cells in neurosphere culture显示文摘 | Ma BF Liu XM Xie XM Zhang AX Zhang JQ Yu WH Zhang XM Li SN Lahn BT Xiang AP | 2006 | 中国生物学文摘2006，20，5： | 4 |
| 17 | An approach to noble-gas isotopic compositions in natural gases and gas-source tracing in the Ordos Basin,China显示文摘Isotopic compositions of noble gases, i.e. He Ar Kr and Xe, are measured in natural gases from the Zhongbu gasfield in the Ordos Basin. And heavy noble-gas isotopes (Kr, Xe) are here first used in geochemically studying natural gases and gas-source correlation. Isotopic compositions of heavy noble gases in natural gases, especially Xe, show two-source mixing in the Zhongbu gasfield. Gas sources are somewhat different in the northeast and the southwest of the gasfield. Generally, the gas source of the Lower Paleozoic makes a greater contribution in the southwest than in the northeast in the field. Two kinds of gases can be differentiated from isotopic compositions of heavy noble gases and from their relation with the Ar isotopic composition. Therefore, the comprehensive study on isotopic compositions of light and heavy noble gases can supply more useful information on gas-source correlation and tracing. | Liu, WH Sun, ML Xu, YC | 2002 | Chinese Science Bulletin2002，47，6： | 3 |
| 18 | 出生到17岁儿童肥胖和血压的关系显示文摘儿童期肥胖易导致成年高血压和糖尿病。研究者已发现儿童期肥胖与青春期早期胰岛素抵抗增加相关。该研究旨在探讨这些肥胖轨迹与儿童期血压发展的关系。方法:在西澳大利亚怀孕队列后代从0到14岁时,采用系列人体测量,通过半参数混合模型描绘出7种肥胖轨迹。Logistic回归分析17岁时这些肥胖轨迹与高血压、正常高值血压发病率的相关性。 | Huang RC Burrows S Mori TA Oddy WH Beilin LJ 练桂丽 | 2015 | 中华高血压杂志2015，23，12： | 3 |
| 19 | 硝酸酯类药物治疗的耐药性、反跳现象和零时效应显示文摘硝酸酯类药物对心绞痛有效,长期持续用药可出现耐药性,间歇用药可避免其发生,但部分病人用药间歇期可有反跳现象和零时效应,故需进一步探索最佳间歇用药方案。 | Frishman WH 王景学 宋书凯 | 1993 | 国外医学(心血管疾病分册)1993，20，5： | 3 |
| 20 | Evolution of Jiuduansha Shoal and Its Influence on Adjacent Channels in the Changjiang Estuary显示文摘-Based on historic topographic maps and field surveys,this paper mainly deals with the forma-tion and evolution of the Jiuduansha Shoal and the North Passage and South Passage in the ChangjiangEstuary.Jiuduansha Shoal originated from the partition of the south part of the Tongsha Shoal as the re-sult of connection of a flood channel and an ebb channel.The embryo of the North Passage was a floodchannel,and that of the South Passage was the lower reaches of the former South Channel.There weretwo basic kinds of change in erosion and accumulation since the formation of Jiuduansha Shoal:continu-ous change and periodic change.The former includes the broadening of the island area,accretion on thetidal marsh and tidal flat and downstream migration of the island.The latter includes cyclic erosion andaccumulation on the two river channel banks of the island and the North and South Passages.The islandand the two bifurcated river Passages interacted on each other in erosion and accumulation changes.Atpresent,the | Xie, WH Yang, SL | 1999 | China Ocean Engineering1999，14，2： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员