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| 1 | 基于流行病学、空间、基因组学数据的中国上海内部人口流动与结核病传播动力学研究显示文摘中国国内人口大规模从农村向城市流动,为结核病控制工作带来了新的挑战。2018年7月的《The Lancet. Infectious diseases》刊载了一项研究,旨在将基因组数据、空间数据和流行病学数据结合起来,描述有大量流动人口的城市环境中结核病的传播动力学特征。研究者们针对上海松江地区的培养阳性结核分枝杆菌开展了一项基于人群的研究。采用全基因组测序法,对具有相同"数目可变串联重复序列(VNTR)"组合的结核分枝杆菌表观基因簇进行了区分,并分析了居住距离与基因学成簇的结合分枝杆菌感染风险之间的关系。 | Yang C Lu L Warren JL | 2018 | 疾病监测2018，33，8： | 17 |
| 2 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 3 | Surface glycoproteins of normal and transformed cells:a difference determined by sialic acid and a growth-dependent sialyl transferase显示文摘 | Warren L Fuhrer JP Buck CA | 1972 | Proc Natl A Scad Sci1972，69，： | 2 |
| 4 | Invasive Lobular carcinoma of the breast:Mammographic characteristics and computer-aided detection显示文摘 | Evans WP Warren Burhenne LJ Lanrie L | 2002 | Radiology2002，225，1： | 1 |
| 5 | Binding and neutralization of endotoxin by Limulus antilipopolysaccharide factor 显示文摘 | Warren H S Glennon M L Wainwright N | 1992 | Infect Immun1992，60，6： | 1 |
| 6 | The influence of temperature and NaCl on cadmium,copper and zinc partitioning among suspended particulate and dissolved phases in an urban river显示文摘 | Warren L A Zimmerman A P | 1994 | Wat Res1994，28，19： | 1 |
| 7 | Improved RT - PCR for diagnosis and epidemiological surveillance of rubella显示文摘 | Cooray S Warrener L Jin L | 2006 | J Clin Virol2006，35，1： | 1 |
| 8 | Inheritance of resistance to exserohilum-turcicum in PI-209135显示文摘 | Robbins W A Warren H L | 1993 | Maydica1993，38，： | 1 |
| 9 | Segmentectomy versus lobectomy in patients with stage I pulmonary carcinoma显示文摘 | William H Warren L Penfield Faber | 1994 | The Journal of Thoracic and Cardiovascular Surgery1994，107，4： | 1 |
| 10 | Nematic 2, 5-disubstituted thiophenes 显示文摘 | Neil L Campbell Warren L Duffy Gareth I Thomas | 2002 | J Mater Chem2002，12，： | 1 |
| 11 | Effect of strain hardening and strain-rate sensitivity on the penetration of aluminum targets with spherical-nosed rods显示文摘 | Warren T L Forrestal M J | 1998 | International Journal of Solids and Structures1998，35，： | 1 |
| 12 | Highly Efficient Re- programming to Pluripotency and Directed Differentiati Human Cells with Synthetic Modified mRNA显示文摘 | Warren L Manos PD Ahfeldt T | 2010 | Cell on of Stem Cell2010，7，5： | 1 |
| 13 | Synthesis and structure of a copper sulfate/kinked organo di- imine coordination显示文摘 | Warren R Knapp Ronald M Supkowski Robert L LaDuca | 2008 | Inorg Chem Commun2008，11，10： | 1 |
| 14 | How bacteria could cause cancer: one step at a time显示文摘 | Alistair J L Warren Thomas | 2002 | Trends Microbiol2002，10，6： | 1 |
| 15 | Effect of B-Site Cation on Electrical Fatigue of RuO2/Pb ( Zrx Ti1-x ) O3/RuO2 Capacitors显示文摘 | Al-Shareef H N Tuttle B A Warren W L | 1996 | Appl Phys1996，79，2： | 1 |
| 16 | Resultsfrom the 1995 national college health risk behavior survey显示文摘 | Douglas K A Collins J L Warren C | 1997 | J Am College Health1997，46，2： | 1 |
| 17 | Longitudinal trends in fluoroquinolone resistance among Enterobacteriaceae isolates from inpatients and outpatients, 1989- 2000: dif- ferences in the emergence and epidemiology of resistance across organisms显示文摘 | Ebbing L Brain LS Warren B | 2004 | Clin Infect Dis2004，38，5： | 1 |
| 18 | Duodenal injuries: surgical management adapted to circumstances 显示文摘 | Jansen M Du Toit D F Warren B L | 2002 | Inju- ry2002，33，7： | 1 |
| 19 | Growth and form of spherulites 显示文摘 | Granasy L P T Tegze G Warren J A | 2005 | Physical Review E2005，72，1： | 1 |
| 20 | Ab Initio Studies of High-Pressure Structural Transformations in Silica 显示文摘 | Karki B B Warren M C Stixrude L | 1997 | Phys Rev B1997，55，6： | 1 |
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