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| 1 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 2 | The acute respiratory distress syndrome显示文摘 | Ware LB Matthay MA | 2000 | N Engl J Med2000，342，18： | 1 |
| 3 | The acute respiratory distress syndrome显示文摘 | Ware LB Matthay MA | 2000 | N Engl J Med2000，342，3： | 1 |
| 4 | Protein C and thrombomodulin in human acute lung injury显示文摘 | Fang X Matthay MA | 2003 | Am J Physiol Lung Cell Mol Physiol2003，285，3： | 1 |
| 5 | Pathogenetic and prog- nostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome显示文摘 | Ware LB Matthay MA Parsons PE | 2007 | Crit Care Med2007，35，8： | 1 |
| 6 | Successful use of anti-CD20(rituximab)in severe,life-threatening childhood immune thrombocytopenic purpura显示文摘 | Bengtson KL Skinner MA Ware RE | 2003 | J Pediatr2003，143，5： | 1 |
| 7 | Microarry analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1显示文摘 | Olman MA White KE Ware LB | 2002 | Chest2002，121，3： | 1 |
| 8 | Protein C and thrombomodulin in human acute lung injury显示文摘 | Ware LB Fang X Matthay MA | 2003 | Am J Physiol Lung Cell Mol Physiol2003，285，3： | 1 |
| 9 | Hydrophobic surfactant proteins and their analogues显示文摘 | Walther F J Waring A J Sherman MA | 2007 | Neonatology2007，91，4： | 1 |
| 10 | The acute respiratory distress syndrome显示文摘 | Matthay MA Ware LB Zimmerman GA | 2012 | J Clin Invest2012，122，8： | 1 |
| 11 | Keratinocyte and hepatocyte growth fac tors in the lung: roles in lung development, inflammation, and re- pair显示文摘 | Ware LB Matthay MA | 2002 | Am J Physiol Lung Cell Mol Physiol2002，282，5： | 1 |
| 12 | Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome显示文摘 | Ware LB Matthay MA | 2001 | Am J Respir Crit Care Med2001，163，6： | 1 |
| 13 | Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome 显示文摘 | Ware LB Matthay MA | 2001 | Am J Respir Crit Care Med2001，163，6： | 1 |
| 14 | Alveolar fluid clearance is im-paired in the majority of patients with acute lung injury and the acute respiratory distress syndrome显示文摘 | Ware LB Matthay MA | 2001 | Am J Re-spir Crit Care Med2001，163，6： | 1 |
| 15 | Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury显示文摘 | Parsons PE Matthay MA Ware LB | 2005 | Am J Physiol Lung Cell Mol Physio12005，288，： | 1 |
| 16 | The acute re- spiratory distress syndrome显示文摘 | Matthay MA Ware LB Zimmerman GA | 2012 | J Clin Invest2012，122，8： | 1 |
| 17 | Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury 显示文摘 | Parsons PE Matthay MA Ware LB | 2005 | Am J Physiol Lung Cell Mol Physiol2005，288，3： | 1 |
| 18 | The acute respiratory distress syn-drome显示文摘 | Ware LB Matthay MA | | 0，，18： | 1 |
| 19 | The acute respiratory distress syndrome 显示文摘 | Matthay MA Ware LB Zimmerman GA | 2012 | J Clin Invest2012，122，8： | 1 |
| 20 | The Acute Respiratory Distress Syndrome 显示文摘 | Ware LB Matthay MA | 2000 | The New England journal of medicine2000，342，18： | 1 |
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