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| 1 | 煤型稀有金属矿床:成因类型、赋存状态和利用评价显示文摘煤和含煤岩系中稀有金属元素的研究,是当今煤地质学研究的热点问题之一。煤和含煤岩系中高度富集并可以开发利用的稀有金属元素包括锂、钪、钛、钒、镓、锗、硒、锆、铌、铪、钽、铀、稀土元素(包括镧系元素和钇)、贵金属元素等。以煤-锗、煤-镓、煤-铀、煤-铌、煤-稀土元素等煤型稀有金属矿床为例,论述了这些矿床的地质成因、赋存状态和利用评价方法。煤型稀有金属矿床的研究,不仅对研究煤层的地质成因、煤层对比、含煤盆地形成与后期改造、区域地质历史演化和突发地质事件可以提供重要的煤地球化学和煤矿物学证据,而且对煤炭经济循环发展、煤炭利用过程中环境保护,以及对国家稀有金属资源安全也具有重要的现实和社会意义。 | 代世峰 任徳贻 周义平 Vladimir VSeredin 李大华 张名泉 James C Hower Colin R Ward 王西勃 赵蕾 宋晓林 | 2014 | 煤炭学报2014，39，8： | 111 |
| 2 | Liver pathology of hepatitis C,beyond grading and stagingof the disease显示文摘Liver biopsy evaluation plays a critical role in management of patients with viral hepatitis C. In patients with acute viral hepatitis, a liver biopsy, though uncommonly performed, helps to rule out other nonviral causes of deranged liver function. In chronic viral hepatitis C, it is considered the gold standard in assessment of the degree of necroinflammation and the stage of fibrosis, to help guide treatment and determine prognosis. It also helps rule out any concomitant diseases such as steatohepatitis, hemochromatosis or others. In patients with chronic progressive liver disease with cirrhosis and dominant nodules, a targeted liver biopsy is helpful in differentiating a regenerative nodule from dysplastic nodule or hepatocellular carcinoma. In the setting of transplantation, the liver biopsy helps distinguish recurrent hepatitis C from acute rejection and also is invaluable in the diagnosis of fibrosing cholestatic hepatitis, a rare variant of recurrent hepatitis C. This comprehensive review discusses the entire spectrum of pathologic findings in the course of hepatitis C infection. | Sadhna Dhingra Stephen C Ward Swan N Thung | 2016 | World Journal of Gastroenterology2016，22，4： | 6 |
| 3 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 4 | 玻璃基底上水滴稳态蒸发过程中的能量传输机制显示文摘采用理论分析和实验测量相结合的方法研究了水滴在玻璃基底上稳态蒸发时内部能量传输机制。发现了气-液、固-液界面温度不连续现象,且越靠近三相接触线,固-液界面温差越大。固-液界面吸附层的存在导致了该界面温度不连续,从玻璃基底导入的大部分热量通过界面吸附层传向三相接触线,然后通过热毛细对流被带向气液界面以满足液滴蒸发所需热量,而另外一小部分热量则直接通过导热进入液滴内部。 | 吴春梅 李友荣 C A Ward | 2013 | 工程热物理学报2013，34，7： | 4 |
| 5 | 免疫组化标记结果显示纤维板层肝癌具有肝细胞和胆管细胞分化特征显示文摘 | Ward S C Huang J Tickoo S K 樊祥山(摘译) | 2010 | 临床与实验病理学杂志2010，26，5： | 3 |
| 6 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 7 | Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms显示文摘 | Coutelle C Ward PJ Fleury B Quattrocchi P Chambrin H Iron A | 1997 | Hum Genet1997，99，3： | 3 |
| 8 | NF-kappaB activition is a critical regulator of human granulocyte apoptosis in vitro显示文摘 | Ward C Chilvers ER Lawson MF | 1999 | J Biol Chem1999，274，7： | 2 |
| 9 | The microwave processability of semicrystalline polymers显示文摘 | M Chen J W Hellgeth E J Siochi T C Ward J E Mcgrath | 1993 | Polymer Engineering and Science1993，33，17： | 2 |
| 10 | Quantitative X-ray powder diffraction analysis of clay minerals in Australian coals using Rietveld methods显示文摘 | RUAN C D WARD C R | 2002 | Appl Clay Sci2002，21，56： | 2 |
| 11 | Mammalian keratin gene families: organization for genes coding for the B2 high-sulphur proteins sheep wool 显示文摘 | Powell B C Sleigh M J Ward K A | 1983 | Nucleic Acids Res1983，11，： | 1 |
| 12 | Micro T-mixer as a rapid mixing micromixer 显示文摘 | WONG S H WARD M C L WHARTON C W | 2004 | Sensors and Actuators B-Chemical2004，100，3： | 1 |
| 13 | Rapid and sensitive colorimetric method for visualizing biotin-labeled DNA probes hybridized to DNA or RNA immobilized on nitrocellulose:bio-blots显示文摘 | Leary J L Brigati D J Ward D C | 1983 | Proc Natl Acad Sci USA1983，80，： | 1 |
| 14 | Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA:differential circulation in mice and rats and the implication for human gene therapy显示文摘 | Ward C M Read M L Seymour L W | 2001 | Blood2001，97，： | 1 |
| 15 | Environmental decision-making and lake management显示文摘 | Cough J D Ward J C | 1995 | Journal of Archaeological Science1995，44，1： | 1 |
| 16 | Brazos River bar: a study in the significance of grain size parameters显示文摘 | FOLK R L WARD W C | 1957 | Journal of Sedimentary Petrology1957，27，： | 1 |
| 17 | 3',5'-diiodothyronine to 3'-monoiodothyronine conversion in the fed and fasted rat:enzyme characteristic and evidence for two distinct 5' -deiodinases 显示文摘 | Smallridge R C Burman K D Ward K E | 1981 | Endocrinology1981，108，： | 1 |
| 18 | Neurologic disease in wapiti naturally infected with meningeal worm显示文摘 | Carpenter J W Jordan H E Ward B C | 1973 | J Wildl Dis1973，9，： | 1 |
| 19 | Temporal trends in breast cancer mortality by state and race显示文摘 | DeSantis C Jemal A Ward E | 2008 | Cancer Causes Control2008，19，5： | 1 |
| 20 | Childhood and adolescent can- cer statistics, 2014 显示文摘 | Ward E Desantis C Robbins A | 2014 | CA Cancer J Clin2014，64，2： | 1 |
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