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| 1 | Simultaneous determination of indapamide,perindopril and perindoprilat in human plasma or whole blood by UPLC-MS/MS and its pharmacokinetic application显示文摘Simple and sensitive methods were developed for the determination of indapamide, perindopril and its active metabolite perindoprilat in human plasma or whole blood by hyphenated ultra-performance liquid chromatography-mass spectrometry(UPLC-MS/MS). Indapamide-d3, perindopril-d4 and perindoprilat-d4 were used as the internal standards. The separation was performed on a Thermo BDS Hypersil C_(18) column(4.6 mm×100 mm, 2.4 mm) for indapamide and perindopril simultaneously following a protein precipitation pretreatment of the biosamples. The separation of perindoprilat was achieved independently on a phenomenex PFP column(4.6 mm×150 mm, 5 mm). All the analytes were quantitated with positive electrospray ionization and multiple reactions monitoring mode. The assay exhibited a linear range of 1–250 ng/mL for indapamide, 0.4–100 ng/mL for perindopril and 0.2–20 ng/mL for perindoprilat. The methods were fully validated to meet the requirements for bioassay in accuracy, precision,recovery, reproducibility, stabilities and matrix effects, and successfully applied to the pharmacokinetic study of perindopril tert-butylamine/indapamide compound tablets in Chinese healthy volunteers and the comparative pharmacokinetic study between plasma and whole blood. | Yi Tao Sheng Wang Lei Wang Min Song Taijun Hang | 2018 | Journal of Pharmaceutical Analysis2018，8，5： | 5 |
| 2 | Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implants显示文摘So far,how to achieve the optimal regenerative repair of large load-bearing bone defects using artificial bone grafts is a huge challenge in clinic.In this study,a strategy of combining osteoinductive biphasic calcium phosphate(BCP)bioceramic scaffolds with intramedullary nail fixation for creating stable osteogenic microenvironment was applied to repair large segmental bone defects(3.0 cm in length)in goat femur model.The material characterization results showed that the BCP scaffold had the initial compressive strength of over 2.0 MPa,and total porosity of 84%.The cell culture experiments demonstrated that the scaffold had the excellent ability to promote the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells(BMSCs).The in vivo results showed that the intramedullary nail fixation maintained the initial stability and structural integrity of the implants at early stage,promoting the osteogenic process both guided and induced by the BCP scaffolds.At 9 months postoperatively,good integration between the implants and host bone was observed,and a large amount of newborn bones formed,accompanying with the degradation of the material.At 18 months postoperatively,almost the complete new bone substitution in the defect area was achieved.The maximum bending strength of the repaired bone defects reached to the 100% of normal femur at 18 months post-surgery.Our results demonstrated the good potential of osteoinductive BCP bioceramics in the regenerative repair of large load-bearing bone defects.The current study could provide an effective method to treat the clinical large segmental bone defects. | Wei Zhi Xiaohua Wang Dong Sun Taijun Chen Bo Yuan Xiangfeng Li Xuening Chen Jianxin Wang Zhao Xie Xiangdong Zhu Kai Zhang Xingdong Zhang | 2022 | Bioactive Materials2022，7，5： | 3 |
| 3 | Nonlinear finite element analysis of concrete structures using new constitutive models显示文摘 | Taijun Wang Thomas T C Hsu | 2001 | Computer and Structures2001，，79： | 1 |
| 4 | A gradient BYY harmony learning rule on Gaussian mixture with automated model selection显示文摘 | Ma Jinwen Wang Taijun Xu Lei | 2004 | Neuro Computing2004，56，： | 1 |
| 5 | Nonlinear finite element analysis of concrete structures using new constitutive models显示文摘 | Taijun Wang Thomas T C H | 2001 | Computers & Structures2001，79，32： | 1 |
| 6 | Nonlinear finite element analysis of concrete structures using new constitutive models显示文摘 | Taijun Wang Thorns T C Hsu | 2001 | Computers and Structures2001，79，： | 1 |
| 7 | Nonlinear finite element analysis of concrete structures using new constitutive models显示文摘 | Wang Taijun Thomas T C H | 2001 | Computer & Structures2001，79，32： | 1 |
| 8 | Nonlinear finite element analysis of concrete structures using new constitutive models 显示文摘 | Wang Taijun Thomas T C H | 2001 | Computers & Structures2001，79，32： | 1 |
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