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| 1 | Outline of the Report on Cardiovascular Disease in China,2010显示文摘Major and profound changes have taken place in China over the past 30 years.Rapid socioeconomic progress has exerted a great impact on lifestyle,ranging from food,clothing,working and living conditions,and means of transportation to leisure activities and entertainment.At the same time,new health problems have emerged,and health services are facing new challenges.Presently,cardiovascular diseases (CVD) are among the top health problems of the Chinese people,and pose a serious challenge to all engaged in the prevention and control of these diseases.An epidemic of CVD in China is emerging as a result of lifestyle changes,urbanization and longevity.Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures.Since 2005,guided by the Bureau of Disease Prevention of the Ministry of Health of the People's Republic of China and the National Center for Cardiovascular Diseases of China,nationwide experts in the fields of epidemiology,clinical medicine and health economics in the realms of CVD,cerebrovascular disease,diabetes and chronic kidney disease,completed the Report on Cardiovascular Diseases in China every year.The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD.In addition,as the report is authoritative,representative and readable,it will become an information platform in the CVD field and an important reference book for government,academic institutes,medical organizations and clinical physicians.This publication is expected to play a positive role in the prevention and control of CVD in China.We present an abstract from the Report on Cardiovascular Diseases in China (2010),including trends in CVD,morbidity and mortality of major CVDs,up-to-date assessment of risk factors,as well as health resources for CVD,and a profile of medical expenditure,with the aim of providing evidence for decision-making in CVD prevention and control programs in China,and of delivering the most authoritative information on CVD prevention and control for all citizens. | HUSheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Wen WANG Yong Jun WU Zhao Su CHEN Wei Wei LIU Ming Bo For the editorial board | 2012 | Biomedical and Environmental Sciences2012，25，3： | 93 |
| 2 | Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway显示文摘Epalrestat is a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy. This study assumed that epalrestat had a protective effect on diabetic peripheral nerve injury by suppressing the expression of aldose reductase in peripheral nerves of diabetes mellitus rats. The high-fat and high-carbohydrate model rats were established by intraperitoneal injection of streptozotocin. Peripheral neuropathy occurred in these rats after sustaining high blood glucose for 8 weeks. At 12 weeks after streptozotocin injection, rats were intragastrically administered epalrestat 100 mg/kg daily for 6 weeks. Transmission electron microscope revealed that the injuries to myelinated nerve fibers, non-myelinated nerve fibers and Schwann cells of rat sciatic nerves had reduced compared to rats without epalrestat administuation. Western blot assay and immunohistochemical results demonstrated that after intervention with epalrestat, the activities of antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase gradually increased, but aldose reductase protein expression gradually diminished. Results confirmed that epalrestat could protect against diabetic peripheral neuropathy by relieving oxidative stress and suppressing the polyol pathway. | Qing-rong Li Zhuo Wang Wei Zhou Shou-rui Fan Run Ma Li Xue Lu Yang Ya-shan Li Hong-li Tan Qi, ng-hua Shao Hong-ying Yang | 2016 | Neural Regeneration Research2016，11，2： | 42 |
| 3 | Summary of Report on Cardiovascular Diseases in China,2012显示文摘The prevalence of cardiovascular diseases(CVDs)is associated with the socioeconomic prosperity,lifestyle changes,accelerated process of ageing and urbanization.The prevalence of CVDs is continuously increasing in China and will remain an upward trend in the next 10 years.CVDs are the leading cause of death for Chinese in both urban area and rural area. | WANG Wen HU Sheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Yong Jun WU Zhao Su CHEN Wei Wei YANG Jin Gang MALi Yuan LIU Ming Bo For the editorial board | 2014 | Biomedical and Environmental Sciences2014，27，7： | 31 |
| 4 | Varicocele and testicular function显示文摘阴囊的精索静脉曲张, pampiniform 丛的静脉的膨胀想了经由静脉的拥挤增加阴囊的温度,通常与男不孕被联系。重要学习在精液参数上澄清了精索静脉曲张的否定影响,更最近的工作有使它的有害效果清楚些在上分子并且精子和阴囊的微型环境的 ultrastructural 特征,以及更多清楚地在 couples’ 上定义处理的积极影响;富饶。当有一段时间基于 histologic 评估知道时,在精索静脉曲张和阴囊的内分泌的功能之间的关系与在精索静脉曲张和性腺机能减退之间的一个成长连接在临床的设置变得更明显。在小儿科的背景,当未来学习将在富饶和阴囊的功能上澄清精索静脉曲张的影响时,最后,最近的工作在青少年和成年人支持精索静脉曲张的平行效果,建议当前的治疗的重新评估考虑到条件的进步性质和未来疾病的潜在的增加的风险来临。 | Alexander W Pastuszak | 2015 | Asian Journal of Andrology2015，17，4： | 32 |
| 5 | Identifying paleoflood deposits archived in Zhongba Site,the Three Gorges reservoir region of the YangtzeRiver,China显示文摘Based on the principle that the present is the key to the past , detailed analyses, such as AMS 14C dating, grain size, component and morphology of heavy minerals, micro-morphology of zircon, Rb/Sr, magnetic susceptibility and total organic carbon (TOC), were conducted to identify paleoflood sediments archived in Zhongba Site. The results indicate that the plaeoflood sediments bear great similarities with modern flood sediments in the following aspects: (1) probability cumulative curves mainly show a pattern of 3―4 segments; (2) grain-size distribution of suspended matter ranges between 3 and 10Ф; (3) the sediments are well-sorted, most of which are suspended matter (>50%); (4) the same species, quantity and morphology of heavy minerals; (5) scanning electronic microscope images show that shapes of zircon are mainly oval and nearly spheral, rounded due to long-distance transport; (6) higher Rb/Sr values (0.55―0.66)than those of sediments from cultural layers (0.03―0.26); (7) magnetic susceptibility values (133.73―433.05 10-6m3/kg) are lower than those of sediments from cultural layers (959.25―2442.44 10?6 m3/kg); (8) TOC (0.14%―0.33%) are lower than those of sediments from cultural lay-ers (1.13%―2.95%). Our results demonstrate that, except for the 1981 flood, there are at least six paleoflood events that occurred during the Qing Dynasty, the middle of Song Dy-nasty, the early Warring States (400BC―350BC), the West Zhou Dynasty (920BC―900BC), the Xia Dynasty (2070BC―1600BC), and the late Neolithic Age (3000BC―2300BC), respectively . | ZHU Chen ZHENG Chaogui MA Chunmei SUN Zhibin ZHU Guangyao WANG Huilin GAO Huazhong WANG Pengling HUANG Run | 2005 | Chinese Science Bulletin2005，50，21： | 28 |
| 6 | Construction of a cucumber genetic linkage map with SRAP markers and location of the genes for lateral branch traits显示文摘Using SRAP (sequence-related amplified polymorphism) markers a genetic linkage map of cucumber was constructed with a population consisting of 138 F2 individuals derived from a cross of the two cucumber lines, S06 and S52. In the survey of parental polymorphisms with 182 primer combinations, 64 polymorphism-revealing primer pairs were screened out, which generated totally 108 polymorphic bands with an average of 1.7 bands per primer pair and at most 6 bands from one primer pair. The constructed molecular linkage map included 92 loci, distributed in seven linkage groups and spanning 1164.2 cM in length with an average genetic distance of 12.6 cM between two neighboring loci. Based on this linkage map, the quantitative trait loci (QTL) for the lateral branch number (lbn) and the lateral branch average length (lbl) in cucumber were identified by QTLMapper1.6. A major QTL lbn1 located between ME11SA4B and ME5EM5 in LG2 could explain 10.63% of the total variation with its positively effecting allele from S06. A major QTL lbl1 located between DC1OD3 and DC1EM14 in LG2 could account for 10.38% of the total variation with its positively effecting allele from S06. | WANG Gang PAN Junsong LI Xiaozun HE Huanle WU Aizhong CAI Run | 2005 | Science China(Life Sciences)2005，48，3： | 24 |
| 7 | Trends of Extreme Precipitation in Eastern China and Their Possible Causes显示文摘Significant increases of heavy precipitation and decreases of light precipitation have been reported over widespread regions of the globe. Global warming and effects of anthropogenic aerosols have both been proposed as possible causes of these changes. We examine data from urban and rural meteorological stations in eastern China(1955–2011) and compare them with Global Precipitation Climatology Project(GPCP) data(1979–2007) and reanalysis data in various latitude zones to study changes in precipitation extremes. Significant decreases in light precipitation and increases in heavy precipitation are found at both rural and urban stations, as well as low latitudes over the ocean, while total precipitation shows little change.Characteristics of these changes and changes in the equatorial zone and other latitudes suggest that global warming rather than aerosol effects is the primary cause of the changes. In eastern China, increases of annual total dry days(28 days) and 10 consecutive dry days(36%) are due to the decrease in light precipitation days, thereby establishing a causal link among global warming, changes in precipitation extremes, and higher meteorological risk of floods and droughts. Further, results derived from the GPCP data and reanalysis data suggest that the causal link exists over widespread regions of the globe. | LIU Run LIU Shaw Chen Ralph J.CICERONE SHIU Chein-Jung LI Jun WANG Jingli ZHANG Yuanhang | 2015 | Advances in Atmospheric Sciences2015，32，8： | 19 |
| 8 | Supramolecular precursor strategy for the synthesis of holey graphitic carbon nitride nanotubes with enhanced photocatalytic hydrogen evolution performance显示文摘A simple one-step thermal polymerization method was developed for synthesis of holey graphitic carbon nitride nanotubes,involving direci eating of mixtures of melamine and urea or melamine and cyanuric acid in specific mass ratios.Supramolecular structures formed betweer the precursor molecules guided nanotube formation.The porous and nanotubular structure of the nanotubes facilitated efficient charge carrier nigration and separation,thereby enhancing photocatalytic Hz production in 20 vol.%lactic acid under visible light irradiation.Nanotubes synthesized using melamine and urea in a 1:10 mass ratio(denoted herein as CN-MU nanotubes)exhibited a photocatalytic hydroger production rate of 1,073.6μmol·h^-1·^-g with Pt as the cocatalyst,a rate of 4.7 and 3.1 times higher than traditional Pt/g-CN4 photocatalysts prepared from graphitic carbon nitride(g-CN4)obtained by direct thermal polymerization of melamine or urea,respectively.On the basis of their outstanding performance for photocatalytic H2 production,it is envisaged that the holey g-C3N4 nanotubes will find widespread uptake in other areas,including photocatalytic CO2 reduction,dye-sensitized solar cells and photoelectrochemical sensors. | Xiaoshuai Wang Chao Zhou Run Shi Qinqin Liu Geoffrey I. N. Waterhouse Lizhu Wu Chen-Ho Tung Tierui Zhang | 2019 | Nano Research2019，12，9： | 15 |
| 9 | The impact of minimally invasive surgeries for the treatment of symptomatic benign prostatic hyperplasia on male sexual function: a systematic review显示文摘使随机化的控制试用和队研究的系统的评论被进行在男性功能上为征兆的良性的 prostatic 增生(BPH ) 的处理为最低限度地侵略的过程的效果评估数据。寻找的研究是与征兆的 BPH 注册了人的试用与激光手术,经尿道的微波治疗( TUMT ),前列腺(金枪鱼)的经尿道的针脱离,前列腺( TEAP )的经尿道的乙醇脱离和高紧张的频率超声( HIFU )被对待,与前列腺( TURP )或假冒的操作的传统的经尿道的切除术比较。72 研究的一个总数被识别,哪个 33 满足了包括标准。33 研究, 21 涉及了激光手术,六与 TUMT,四与金枪鱼并且二与包含信息考虑的 TEAP 男性功能。没有学习关于为男性功能上的 BPH 的 HIFU 的效果是可得到的。我们的分析证明为 BPH 的最低限度地侵略的手术在男可勃起的功能上 TURP 有可比较的效果到那些。一起,分别地,不到 15.4% 病人或 15.2% 将在激光过程, TUMT 和金枪鱼以后可勃起的功能有减少或增加。是与 TURP 观察了,射精的机能障碍(EjD ) 的高发生在有钬, potassium-titanyl-phosphate 和铥激光治疗的 BPH 的治疗以后是普通的(>33.6%) 。TUMT,金枪鱼和 neodymium:yttrium 铝石榴石为 BPH 的视觉激光脱离或空隙的激光凝结有更少的发生 EjD,而是这些过程为 BPH 治疗被认为更少有效什么时候与 TURP 相比。 | Ryan W. Frieben Hao-Cheng Lin Peter E Hinh Francesco Berardinelli Steven E. Canfield Run Wang | 2010 | Asian Journal of Andrology2010，12，4： | 13 |
| 10 | RAB31 marks and controls an ESCRT-independent exosome pathway显示文摘Exosomes are generated within the multivesicular endosomes(MVEs)as intraluminal vesicles(ILVs)and secreted during the fusion of MVEs with the cell membrane.The mechanisms of exosome biogenesis remain poorly explored.Here we identify that RAB31 marks and controls an ESCRT-independent exosome pathway.Active RAB31,phosphorylated by epidermal growth factor receptor(EGFR),engages flotillin proteins in lipid raft microdomains to drive EGFR entry into MVEs to form ILVs,which is independent of the ESCRT(endosomal sorting complex required for transport)machinery.Active RAB31 interacts with the SPFH domain and drives ILV formation via the Flotillin domain of flotillin proteins.Meanwhile,RAB31 recruits GTPase-activating protein TBC1D2B to inactivate RAB7,thereby preventing the fusion of MVEs with lysosomes and enabling the secretion of ILVs as exosomes.These findings establish that RAB31 has dual functions in the biogenesis of exosomes:driving ILVs formation and suppressing MVEs degradation,providing an exquisite framework to better understand exosome biogenesis. | Denghui Wei Weixiang Zhan Ying Gao Liyan Huang Run Gong Wen Wang Ruhua Zhang Yuanzhong Wu Song Gao Tiebang Kang | 2021 | Cell Research2021，31，2： | 12 |
| 11 | Endocrine disruptors and estrogenic effects on male reproductive axis显示文摘内分泌的 disrupt ors (例如, polychlorinated 联本基[印刷电路板] , dichlorodiphenyl-trichloroethane [DDT ] ,戴奥辛,和一些杀虫剂) 是像雌激素的并且在环境的 anti-androgenic 化学药品。他们模仿自然荷尔蒙,禁止荷尔蒙的行动,或改变内分泌系统的正常规章的功能并且有引起不孕的男繁殖的轴上的潜在的危险效果。尽管阴囊并且前列腺癌症,反常性开发,波形的 scended 睾丸,慢性炎, Sertoli-cell-only,模式,尿道下裂,改变的垂体和甲状腺腺函数也被观察,可得到的数据是不够的推出世界范围的结论。intra 细胞质的精子注射(ICSI ) 的发展在疑问以外是在男不孕的治疗的最重要的最近的突破,但是它未必确实对待原因并且可以无意中传递不利基因后果。在生理学,生物化学,和雄性生殖系统的分子、细胞的生物学的许多控制得好的临床的研究和基本科学发现在人的更大的数字的鉴定帮助了解决男因素问题。为 Y 染色体删除的察觉的更新的工具进一步加强了处于男繁殖健康和富饶的衰落可能与在环境的某些有毒的化学药品的存在有关的假设。因此,男因素不孕的病原学,诊断,和治疗仍然是真实挑战。临床医生们应该总是试图识别可能的阴囊的毒性的病原学,估计风险的度到为不孕被评估的病人,并且开始一个计划一旦在职业 / 有毒物和不孕之间的一个协会被建立了,控制并且阻止到其它的暴露。 | Suresh C. Sikka Run Wang | 2008 | Asian Journal of Andrology2008，10，1： | 12 |
| 12 | Computed morphometric analysis and expression of alpha fetoprotein in hepatocellular carcinoma and its related lesion显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is closely relatedwith hepatitis and cirrhosis.In order to investigatethe pathogenesis and early pathologic diagnosis ofHCC,HCC and related lesions were analyzedqualitively and quantitively by automatic imageanalysor and immunohistochemical assay. | Li Juan Shen Zong Ji Zhang Yang Ming Ou Hua Xian Zhang Run Huang Yun He Min Jie Wang Guo Shu Xu | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 13 | 真空勃起装置在前列腺癌根治术后阴茎康复治疗中的应用显示文摘真空勃起装置(VED)是利用负压吸引血流进入阴茎海绵体,从而促使阴茎勃起的一种装置。使用它可以进行阴茎康复治疗或者可以合用弹力环来维持勃起状态来满足性交需求。由于磷酸二酯酶5型抑制剂(PDE5i)在治疗难治性ED中的局限性,VED重新崛起并逐渐成为治疗前列腺癌根治手术后勃起功能障碍(ED)的一线治疗手段。目前,前列腺癌根治手术后早期应用VED和PDE5I的联合治疗以及VED和海绵体注射治疗(ICI)的联合治疗引起广泛的关注。因此,我们在这里回顾了VED在阴茎康复治疗中的角色,潜在的机制以及联合治疗的效果。 | 林浩成 Grace Wang Run Wang | 2015 | 中华男科学杂志2015，21，3： | 11 |
| 14 | Laparoscopic hepatectomy by curettage and aspiration:a new technique显示文摘背景 Laparoscopic 外科为最小的侵略和快速的手术后的恢复是有益的。自从在在 1990 年代的肝切除术的 laparoscopic hepatectomy 的使用,它在有效、安全的技术的一些机构 worldwide.Lack 被执行了因为肝办理是在 1998 由刮术和渴望为 laparoscopic hepatectomy 阻止一种新技术它开发的进一步的 development.We 的主要障碍。在这份报纸,我们总共在 7 年 practice.Methods 以后分析这种技术的临床的结果 59 个连续病人在我们的机构从 1998 年 8 月由刮术和渴望经历了 laparoscopic hepatectomy 到 2005 年 1 月。这些病人包括了 33 男性和 26 女性,与 47 年的吝啬的年龄。为肝 transecsion laparoscopic, Peng 的多功能的起作用的析象器(LPMOD ) 被使用。损害在 5 .Procedures 在 19 个病人,在 17 的良性的肝肿瘤,在 18 的 intrahepatic 演算,和另外的肝损害包括了恶意的肝肿瘤在 30 个病人,的包括的本地切除术离开了在 28 的侧面的 segmentectomy,和权利在 1 个 .Results Laparoscopic 手术的 hemihepatectomy 在 57 个病人被完成。二个病人(3.4%) 把操作变换成剖腹术。吝啬的操作时间是 143 分钟,吝啬的 intraoperative 血损失是 456 mi。手术后的医院停留的吝啬的长度是 7 天。复杂并发症在 2 个病人(3.4%) 发生了,并且由刮术没有 perioperative death.Conclusion Laparoscopic hepatectomy,渴望为肝切除术有效、安全。 | CAI Xiu-jun LIANG Xiao WANG Yi-fan YU Hong ZHENG Xue-yong HUANG Di-yu PENG Shu-you Department of General Surgery,Sir Run Run Shaw Hospital,College of Medicine Institute of Minimally Invasive Surgery of Zhejiang University,Hangzhou 310016,China (Cai XJ,Liang X,Wang YF,Yu H,Zheng XY,Huang DY and Peng SY) | 2007 | Chinese Medical Journal2007，，20： | 11 |
| 15 | Electropharmacological properties of telmisartan in blocking hKvl.5 and HERG potassium channels expressed on Xenopus laevis oocytes^1显示文摘瞄准:这研究的目的是调查 telmisartan 的禁止的行动,一种选择血管收缩素 II 类型 1 个受体对手,在 hKv1.5 和人的 ether-a-go-go-related 上,基因(HERG ) 隧道在 Xenopus laevis 卵母细胞上表示了。方法:hKv1.5 和 HERG 隧道在 Xenopus laevis 卵母细胞上被表示并且用 2-microelectrode 电压学习了夹钳技术。结果:在 hKv1.5 隧道, telmisartan 生产了电压依赖者和集中依赖者抑制;封锁的功效在山峰和 1.5 s 结束脉搏电流是不同的,它是 7.75%± 2 .39%( 一半最大的抑制集中[IC 50]=2.25 ± 0.97 μmol/L ) 并且在 1 μmol/L telmisartan 的 52.64%± 3 .77%(IC 50=0.82 ± 0.39 μmol/L ) 分别地。同时, telmisartan 加速了在里面隧道的激活。然而, telmisartan 为 HERG 隧道(IC 50=24.35 ± 5.06 μmol/L ) 展出了一种低亲密关系;封锁是电压依赖者和集中依赖者。Telmisartan 优先地堵住了开状态的 HERG 隧道。释放的慢时间常数被加速(n=6, P<0.05 ) ,它与“ foot-in-the-door ”不一致效果。结论:Telmisartan 堵住在治疗学的剂量的血浆集中层次包含开、使 \O 失去活性的状态的 hKv1.5 钾隧道;而 HERG 隧道的封锁仅仅在在上发生,血浆集中在开、靠近状态的隧道治疗学的剂量并且优先地铺平。 | Dan-na TU Yu-hua LIAO An-ruo ZOU Yi-mei DU Qi RUN Xian-pei WANG Lu LI | 2008 | Acta Pharmacologica Sinica2008，29，8： | 10 |
| 16 | Micro-trichome as a class I homeodomain-leucine zipper gene regulates multicellular trichome development in Cucumis sativus显示文摘Plant trichomes serve as a highly suitable model for investigating cell differentiation at the single-cell level.The regulatory genes involved in unicellular trichome development in Arabidopsis thaliana have been intensively studied,but genes regulating multicellular trichome development in plants remain unclear.Here,we characterized Cucumis sativus(cucumber) trichomes as representative multicellular and unbranched structures,and identified Micro-trichome(Mict),using map-based cloning in an F_2 segregating population of7,936 individuals generated from a spontaneous mict mutant.In mict plants,trichomes in both leaves and fruits,are small,poorly developed,and denser than in the wild type.Sequence analysis revealed that a 2,649-bp genomic deletion,spanning the first and second exons,occurred in a plant-specific class I homeodomain-leucine zipper gene.Tissue-specific expression analysis indicated that Mict is strongly expressed in the trichome cells.Transcriptome profiling identified potential targets of Mict including putative homologs of genes known in other systems to regulate trichome development,meristem determinacy,and hormone responsiveness.Phylogenic analysis charted the relationships among putative homologs in angiosperms.Our paper represents initial steps toward understanding the development of multicellular trichomes. | Jun-Long Zhao Jun-Song Pan Yuan Guan Wei-Wei Zhang Bei-Bei Bie Yun-Li Wang Huan-Le He Hong-Li Lian Run Cai | 2015 | Journal of Integrative Plant Biology2015，57，11： | 9 |
| 17 | Common approach to managing lower urinary tract symptoms and erectile dysfunction显示文摘现在的纸用作在更低的泌尿道症状(LUTS ) 和可勃起的机能障碍(编辑) 之间的协会的评论,与为处理的普通、联合的小径的一个焦点。LUTS 和编辑是看见的普通条件一般来说泌尿科的实践。研究开始建立了流行病并且轻拍惊讶在二个条件和一个强壮的协会之间的生理的连接证实了到对面多重的研究。为一个条件寻求照顾的人应该总是为另外的条件的抱怨被会见。建议普通小径包括α - 1 肾上腺素能的受体不平衡,在活动上的 Rho-kinase,内皮房间机能障碍和导致动脉粥样硬化的局部缺血。医药治疗在大多数病人为 LUTS 作为首要的治疗代替了外科,与肾上腺素能的受体对手(α - ARA ) 和进每天的 5- α - 还原酶禁止者(5-ARIs ) 练习的α - 的加入。有α - ARA 的治疗在编辑贡献某改进,而 5-ARIs 的使用在一些病人导致变得更坏的性功能。Phosphodiesterase-5 (PDE-5 ) 禁止者与简单口头的政体革命化了编辑的治疗,并且新卓见表明 PDE-5 禁止者和α - ARA 的联合使用的一个好处。这些药的行动的机制支持这些观察好处,并且他们在基本科学和临床的背景正在被学习。另外,为治疗的新奇机制被建议了基于临床并且研究观察。最低限度地侵略并且为 LUTS 的外科疗法被知道在射精的功能上有不利效果,当他们可勃起的功能上的效果仍然被辩论时。大部分尚待被调查,但是在 LUTS 和编辑之间的协会为未来治疗和可能的预防策略打了基础,是清楚的。 | Jennifer M. Taylor Rowena DeSouza Run Wang | 2008 | Asian Journal of Andrology2008，10，1： | 9 |
| 18 | Penile rehabilitation with a vacuum erectile device in an animal model is related to an antihypoxic mechanism: blood gas evidence显示文摘我们的以前的学习显示出可勃起的设备(VED ) 治疗改进了的那真空在有双边的多孔的神经压碎(BCNC ) 的老鼠的可勃起的功能损害。这研究被设计由分析多孔的氧浸透在阴茎康复探索 VED 的机制(那么 2) 并且在在 BCNC 以后阻止阴茎收缩上检验 VED 治疗的效果。三十只成年 Sprague-Dawley 老鼠随机被分配进三个组:组织 1,假冒的外科;组织 2, BCNC;并且组织 3, BCNC+ VED。阴茎长度和直径在一个每周的基础上被测量。在 4 星期治疗以后,阴茎血被三个方法为血气体分析(BGA ) 提取:方法 1,多孔的血以松驰的状态被把发成送气音;方法 2,多孔的血以拖拉状态被把发成送气音;并且方法 3,多孔的血在使用 VED 以后立即被把发成送气音。2 价值被血气体分析器因此测试。结果证明那 VED 治疗在阻止 BCNC 导致的阴茎收缩是有效的(阴茎弄短:BCNC 组 1.9 ± 1.1 公里;VED 组 0.3 ± 1.0 公里;P< 0.01。阴茎直径减小:BCNC 组 0.28 ± 0.14 公里;VED 组 0.04 ± 0.14 公里;P< 0.01 ) 。2±s.d. 因此珍视的平均数被 VED 申请增加(88.25 % ± 4.94 %) 与相比松驰(76.53 % ± 4.16 %) 或拖拉组(78.93 % ± 2.56 %)(P< 0.05 ) 。在在 VED 申请以后的阴茎海绵体权利的计算的血构造是 62 %动脉并且 38 %静脉的血。这些调查结果建议那 VED 治疗能有效地与 BCNC 损害在老鼠保存阴茎尺寸。VED 治疗的有益的效果与由那么增加多孔的血的 antihypoxia 有关是 2 。 | Hao-Cheng Lin Wen-Li Yang Jun-Lan Zhang Yu-Tian Dai Run Wang | 2013 | Asian Journal of Andrology2013，15，3： | 9 |
| 19 | Two gap-free reference genomes and a global view of the centromere architecture in rice显示文摘Rice(Oryza sativa),a major staple throughout the world and a model system for plant genomics and breeding,was the first crop genome sequenced almost two decades ago.However,reference genomes for all higher organisms to date contain gaps and missing sequences.Here,we report the assembly and analysis of gap-free reference genome sequences for two elite O.sativa xian/indica rice varieties,Zhenshan 97 and Minghui 63,which are being used as a model system for studying heterosis and yield.Gap-free reference genomes provide the opportunity for a global view of the structure and function of centromeres.We show that all rice centromeric regions share conserved centromere-specific satellite motifs with different copy numbers and structures.In addition,the similarity of CentO repeats in the same chromosome is higher than across chromosomes,supporting a model of local expansion and homogenization.Both genomes have over 395 non-TE genes located in centromere regions,of which∼41%are actively transcribed.Two large structural variants at the end of chromosome 11 affect the copy number of resistance genes between the two genomes.The availability of the two gap-free genomes lays a solid foundation for further understanding genome structure and function in plants and breeding climate-resilient varieties. | Jia-Ming Song Wen-Zhao Xie Shuo Wang Yi-Xiong Guo Dal-Hoe Koo Dave Kudrna Chenbo Gong Yicheng Huang Jia-Wu Feng Wenhui Zhang Yong Zhou Andrea Zuccolo Evan Long Seunghee Lee Jayson Talag Run Zhou Xi-Tong Zhu Daojun Yuan Joshua Udall Weibo Xie Rod AWing Qifa Zhang Jesse Poland Jianwei Zhang Ling-Ling Chen | 2021 | Molecular Plant2021，14，10： | 9 |
| 20 | Parainfluenza Virus Types 1, 2, and 3 in Pediatric Patients with Acute Respiratory Infections in Beijing During 2004 to 2012显示文摘 | Fang Wang Lin-Qing Zhao Ru-Nan Zhu Jie Deng Yu Sun Ya-Xin Ding Run Tian Yuan Qian | 2015 | Chinese Medical Journal2015，，20： | 8 |
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