3篇
您的检索式：作者名="Wang Chenqiu"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Osteogenic effects of antihypertensive drug benidipine on mouse MC3T3-E1 cells in vitro显示文摘Hypertension is a prevalent systemic disease in the elderly,who can suffer from several pathological skeletal conditions simultaneously,including osteoporosis.Benidipine(BD),which is widely used to treat hypertension,has been proved to have a beneficial effect on bone metabolism.In order to confirm the osteogenic effects of BD,we investigated its osteogenic function using mouse MC3T3-E1 preosteoblast cells in vitro.The proliferative ability of MC3T3-E1 cells was significantly associated with the concentration of BD,as measured by methylthiazolyldiphenyl-tetrazolium bromide(MTT)assay and cell cycle assay.With BD treatment,the osteogenic differentiation and maturation of MC3T3-E1 cells were increased,as established by the alkaline phosphatase(ALP)activity test,matrix mineralized nodules formation,osteogenic genetic test,and protein expression analyses.Moreover,our data showed that the BMP2/Smad pathway could be the partial mechanism for the promotion of osteogenesis by BD,while BD might suppress the possible function of osteoclasts through the OPG/RANKL/RANK(receptor activator of nuclear factor-κB(NF-κB))pathway.The hypothesis that BD bears a considerable potential in further research on its dual therapeutic effect on hypertensive patients with poor skeletal conditions was proved within the limitations of the present study. | Baixiang WANG Jiakang YANG Lijie FAN YuWANG Chenqiu ZHANG HuimingWANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，5： | 2 |
| 2 | Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex显示文摘Currently,the incidence and fatality rate of SARS-CoV-2 remain continually high worldwide.COVID-19 patients infected with SARS-CoV-2 exhibited decreased type I interferon(IFN-I)signal,along with limited activation of antiviral immune responses as well as enhanced viral infectivity.Dramatic progresses have been made in revealing the multiple strategies employed by SARS-CoV-2 in impairing canonical RNA sensing pathways.However,it remains to be determined about the SARS-CoV-2 antagonism of cGAS-mediated activation of IFN responses during infection.In the current study,we figure out that SARS-CoV-2 infection leads to the accumulation of released mitochondria DNA(mtDNA),which in turn triggers cGAS to activate IFN-I signaling.As countermeasures,SARS-CoV-2 nucleocapsid(N)protein restricts the DNA recognition capacity of cGAS to impair cGAS-induced IFN-I signaling.Mechanically,N protein disrupts the assembly of cGAS with its co-factor G3BP1 by undergoing DNA-induced liquid-liquid phase separation(LLPS),subsequently impairs the double-strand DNA(dsDNA)detection ability of cGAS.Taken together,our findings unravel a novel antagonistic strategy by which SARS-CoV-2 reduces DNA-triggered IFN-I pathway through interfering with cGAS-DNA phase separation. | Sihui Cai Chenqiu Zhang Zhen Zhuang Shengnan Zhang Ling Ma Shuai Yang Tao Zhou Zheyu Wang Weihong Xie Shouheng Jin Jincun Zhao Xiangdong Guan Jianfeng Wu Jun Cui Yaoxing Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 3 | Spatial Distribution Characteristics of Forest Parks in Shandong Province显示文摘The spatial distribution characteristics of forest parks in Shandong Province were studied using geographical concentration index,Gini coefficient,and ArcGIS analysis software.The results show that the forest parks in Shandong Province are concentrated in the province and in the five subregions,and the equilibrium degree of the distribution is low.The density of forest parks in Shandong Province is high in eastern Shandong and central Shandong but low in western Shandong.The number of forest parks in the eastern coastal areas of Shandong Province is larger than the number of forest parks in the inland areas of Shandong Province. | Zhao Weijun Peng Shuzhen Liu Xiaomei Zhang Dongmei Han Junqing Gao Mengyuan Wang Chenqiu | 2019 | Meteorological and Environmental Research2019，10，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员