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| 1 | Is obesity associated with gastropharyngeal reflux disease?显示文摘AIM: To examine the association between obesity and gastropharyngeal reflux disease (GPRD) as well as gastroesophageal reflux disease (GERD) METHODS: We conducted a cross-sectional study of consecutive patients undergoing ambulatory 24-h dual-probe pH monitoring from July 2003 to December 2006. The association between body mass index (BMI) and parameters about gastroesophageal or gastropharyngeal reflux was examined in univariate and multivariate analyses.RESULTS: A total of 769 patients (307 men and 462 women; mean age 50.7 years) were finally enrolled. Most variables showing gastroesophageal reflux was higher in the obese patients than the patients with normal BMI. There was no difference in all the variables showing gastropharyngeal reflux according to the BMI. After adjustment for age, sex, alcohol intake and smoking, obese patients demonstrated an about 2-fold increase in risk of GERD compared with patients with normal BMI (OR, 1.9; 95 CI, 1.3-2.9), but overweight patients did not demonstrate increased risk of GERD (OR, 1.2; 95 CI, 0.8-1.7). Both obese patients and overweight patients did not demonstrated increased risk of GPRD compared with patients with normal BMI (OR, 1.1; 95 CI, 0.8-1.7; and OR, 0.9; 95 CI, 0.6-1.3, respectively).CONCLUSION: Obesity is not associated with GPRD reflux while it is associated with GERD. | Cheol Woong Choi Gwang Ha Kim Chul Soo Song Soo Geun Wang Byung Joo Lee Hoseok I Dae Hwan Kang Geun Am Song | 2008 | World Journal of Gastroenterology2008，14，2： | 5 |
| 2 | 年龄>75岁成人他汀类药物的使用情况及不良反应显示文摘自2013年美国心脏病学会/美国心脏协会指南发布以来,目前常规社区治疗实践中老年人用他汀类药物情况不很清楚。研究者比较了在不考虑指南推荐的年龄标准的情况下,符合接受一级或二级预防他汀类药物使用标准年龄〉75和≤75岁成年人的他汀类药物使用和剂量状况。 | 刘青 叶鹏 Nanna MG Navar AM Wang TY Mi X Virani SS Louie MJ Lee LV Goldberg AC Roger VL Robinson J Peterson ED | 2018 | 中华高血压杂志2018，26，7： | 4 |
| 3 | Is ineffective esophageal motility associated with gastropharyngeal reflux disease?显示文摘AIM: To evaluate the association between ineffective esophageal motility (IEM) and gastropharyngeal reflux disease (GPRD) in patients who underwent ambulatory 24-h dual-probe pH monitoring for the evaluation of supraesophageal symptoms. METHODS: A total of 632 patients who underwent endoscopy,esophageal manometry and ambulatory 24-h dual-pH monitoring due to supraesophageal symptoms (e.g. globus,hoarseness,or cough) were enrolled. Of them,we selected the patients who had normal esophageal motility and IEM. The endoscopy and ambulatory pH monitoring findings were compared between the two groups. RESULTS: A total of 264 patients with normal esophageal motility and 195 patients with the diagnosis of IEM were included in this study. There was no difference in the frequency of reflux esophagitis and hiatal hernia between the two groups. All the variables showing gastroesophageal reflux and gastropharyngeal reflux were not different between the two groups. The frequency of GERD and GPRD,as defined by ambulatory pH monitoring,was not different between the two groups. CONCLUSION: There was no association between IEM and GPRD as well as between IEM and GERD. IEM alone cannot be considered as a definitive marker for reflux disease. | Kyung Yup Kim Gwang Ha Kim Dong Uk Kim Soo Geun Wang Byung Joo Lee Jin Choon Lee Do Youn Park Geun Am Song | 2008 | World Journal of Gastroenterology2008，14，39： | 3 |
| 4 | Genetics of Fertility Restoration in Cytoplasmic Male Sterile Pepper显示文摘Pepper hybrid seeds production using male sterility could lower cost by reducing time and labour, and increase thegenetic purity of the F1 seeds. To investigate the genetics of fertility restoration of the Peterson cytoplasmic sterility inpepper, a doubled haploid population of 115 pepper lines obtained from anther culture of the F1 hybrid between YoloWonder (sterility maintainer line) and Perennial (fertility restorer line) and the parental lines were test-crossed by 77013A(a strict cytoplasmic-genic male sterile line). The fertility of the test-crossed lines was assessed in greenhouse and openfield with the following three criteria: pollen index (PI, visual estimation of pollen amount per flower), pollen number (PN,pollen counting under microscope), and seed number (SN, the number of seeds per fruit in open pollination). Correlationsbetween the each couple of criteria within, as well as between the cultivation methods ranged from 0.55 to 0.84. Analysisof variance showed that the genotype (DH line) and environment were the significant sources of variation of the fertility.Narrow sense of heritance of fertility restoration ranged from 0.38 to 0.92, depending on the criteria and environment. Thedistribution of the progeny was continuous between the parental genotypes indicating the quantitative inheritance offertility restoration. Inferred from segregation according to Snape et al.(1984), the number of segregating genes wasestimated to be that three to four genetic factors were involved in pollen traits (PI and PN) and five to eight genetic factorsin seed production (SN). The heredity analysis of the CMS will be helpful for understanding of the genetic mechanism ofthe fertility restoration and the exploitation of the CMS in hybrid seed production. | WANG Li-hao ZHANG Bao-xi AM Daubeze HUANG San-wen GUO Jia-zhen MAO Sheng-li A Palloix DU Yong-chen | 2006 | Agricultural Sciences in China2006，5，3： | 3 |
| 5 | Census of Kuiper Comets-the TAOS Project显示文摘Cometary nuclei, the remnant icy bodies of planet formation, located at the outer edge of the solar system, are relatively poorly studied because of their small sizes and thus faintness. Thus far more than a hundred large members (size about 100 km) of this cometary population in the Kuiper belt have been identified. Smaller bodies (10 km) are much too faint to image directly and their number so far can only be extrapolated on theoretical grounds. The Taiwan-America Occultation Survey (TAOS) will conduct a census of the number of Kuiper belt objects down to a few km size by monitoring chance stellar occultations by these cometary nuclei. We will set up an array of small (50cm), wide-field (f/1 9) telescopes, each equipped with a 2K squared CCD camera, along a 7 km baseline in central Taiwan at an elevation above ~ 3000 m. The robot telescopes will operate in a coincidence mode, so the sequence and timing of any candidate occultation event can be recorded and distinguished against a false detection. The Lawrence Livermore National Laboratory, the National Central University, and the Academia Sinica, will each contribute one telescope system. Researchers from an international variety of institutes are also participating in the project. Our experiment provides the only means to study the cometary population in the small-sized end of the distrbution. A great number of scientific byproducts, notably variable stars, will also derive from the huge TAOS database, some 10, 000 giga-bytes worth of photometrical measuremements per year. | Wen Ping ChenOther TAOS team members: C. Alcock, K. Cook, S. Marshall, M. Hammergren(LLNL) T. Lee, C. Yuan, C. Y. Wen, S. K. King(ASIAA) W. S. Tsay, W. Ip, C. Lemme, J. H. Wang(NCU) T. Axelrod(ANU) I. de Pater(UCB) J.Lissauer(Ames) Y. I. Byun(Yonsei | 1999 | 天文研究与技术1999，，S1： | 3 |
| 6 | Structural and magnetic properties of nanogranular Co-Pt/C films 显示文摘 | Li Tong Zhou Yun-song | 2003 | Thin Solid Fims2003，445，1： | 1 |
| 7 | Bone development 显示文摘 | Olsen BR AM Reginato W Wang | 2000 | Ann rev cell Developm Biol2000，16，1： | 1 |
| 8 | The influence of St John's wort on CYP2C19 activity with respect to genotype显示文摘 | Wang LS Zhu B El -Aty AM | 2004 | J Clin Pharmacol2004，44，： | 1 |
| 9 | Stromal cell-derived factor 1 alpha mediates neural progenitor cell motility after focal cerebral ischemia显示文摘 | Robin AM Zhang ZG Wang L | 2006 | J Cereb Blood Flow Metab2006，26，1： | 1 |
| 10 | Site - specific UBITh amyloid - beta vaccine for immunotherapy of Alzheimer's disease显示文摘 | Wang CY Finstad CL Walfield AM | 2007 | Vaccine2007，25，16： | 1 |
| 11 | Induction of p21 wafl expression and growth inhibition by transforming growth factor bate involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells显示文摘 | Zhang L Wang W | 2001 | Cancer Res2001，57，18： | 1 |
| 12 | Characterization of human immunodeficiency virus type 1 replication in immature and mature dendritic cells reveals dissociable cis-and trans-infection显示文摘 | Dong C Janas AM Wang JH | 2007 | J Virol2007，81，11： | 1 |
| 13 | Multiple effects of hypothermia on inflammatory response following ischemia-reperfusion injury in experimental ischemic neuropathy显示文摘 | Kawamura N Schmeichel AM Wang Y | 2006 | Exp Neurol2006，202，2： | 1 |
| 14 | Cancer immunomics: using autoantibody signatures in the early detection of prostate cancer 显示文摘 | Bradford TJ Wang X Chinnaiyan AM | 2006 | Urol Oncol2006，24，3： | 1 |
| 15 | Incorporation and integration of implanted myogenic and stem cells into native myocardial fibers: anatomic basis for functional improvement显示文摘 | Chedrawy EG Wang JS Wobus AM | 2002 | J Thora Cardiovas Surg2002，124，3： | 1 |
| 16 | Crystallization and preliminary crystallographic studies of SAM domain at the c-ternunus of human p73 alpha显示文摘 | Wang WK Proctor MR Buckle AM | | 0，，： | 1 |
| 17 | Preparation of starch-based nano-particles through high-pressure homogenization and miniemul-sion cross-linking:Influence of various process parameters on particle size and stability 显示文摘 | Shi AM Li D Wang LJ | | 0，，04： | 1 |
| 18 | Myocyte remodeling during the progression to failure in rats with hypertension显示文摘 | Onodera T Wang X | 1996 | Hypertension1996，28，4： | 1 |
| 19 | Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma 显示文摘 | Wang M Tihan T Rojiani AM | 2005 | J Neuropathol Exp Neurol2005，64，10： | 1 |
| 20 | Increased treatment-related mortality with additional cisplatin-based chemotherapy in patients with nasopharyngeal carcinoma treated with standard radiotherapy 显示文摘 | Zhang AM Fan Y Wang XX | 2012 | Radiother Oncol2012，104，3： | 1 |
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