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| 1 | Incidence of gastroesophageal reflux disease in Uygur and Han Chinese adults in Urumqi显示文摘AIM:To investigate the incidence of gastroesophageal reflux disease(GERD) and its related risk factors in Uygur and Han Chinese adult in Urumqi,China.METHODS:A population-based cross-sectional survey was undertaken in a total of 972 Uygur(684 male and 288 female) aged from 24 to 61 and 1023 Han Chinese(752 male and 271 female) aged from 23 to 63 years.All participants were recruited from the residents who visited hospital for health examination from November 2011 to May 2012.Each participant signed an informed consent and completed a GERD questionnaire(GerdQ) and a lifestyle-food frequency questionnaire survey.Participants whose Gerd Q score was ≥ 8 and met one of the following requirements would be enrolled into this research:(1) being diagnosed with erosive esophagitis(EE) or Barrett's esophagus(BE) by endoscopy;(2) negative manifestation under endoscopy(non-erosive reflux disease,NERD) with abnormal acid reflux revealed by 24-h esophageal pH monitoring;and(3) suffering from typical heartburn and regurgitation with positive result of proton pump inhibitor test.RESULTS:According to Gerd Q scoring criteria,340 cases of Uygur and 286 cases of Han Chinese were defined as GERD.GERD incidence in Uygur was significantly higher than in Han Chinese(35% vs 28%,χ2 = 11.09,P < 0.005),Gerd Q score in Uygur was higher than in Han Chinese(7.85 ± 3.1 vs 7.15 ± 2.9,P < 0.005),and Gerd Q total score in Uygur male was higher than in female(8.15 ± 2.8 vs 6.85 ± 2.5,P < 0.005).According to normalized methods,304(31%) cases of Uygur were diagnosed with GERD,including 89 cases of EE,185 cases of NERD and 30 cases of BE;256(25%) cases of Han Chinese were diagnosed with GERD,including 90 cases of EE,140 cases of NERD and 26 cases of BE.GERD incidence in Uygur was significantly higher than in Han Chinese(31% vs 25%,χ2 = 9.34,P < 0.005) while the incidences were higher in males of both groups than in females(26% vs 5% in Uygur,χ2 = 35.95,P < 0.005,and 19.8% vs 5.2% in Han,χ2 = 5.48,P < 0.025).GERD incidence in Uygur male was higher than in Han Chinese male(26% vs 19.8%,χ2 = 16.51,P < 0.005),and incidence of NERD in Uygur was higher than in Han Chinese(χ2 = 10.06,P < 0.005).Occupation(r = 0.623),gender(r = 0.839),smoking(r = 0.322),strong tea(r = 0.658),alcohol drinking(r = 0.696),meat-based diet(mainly meat)(r = 0.676) and body mass index(BMI)(r = 0.567) were linearly correlated with GERD in Uygur(r = 0.833,P = 0.000);while gender(r = 0.957),age(r = 0.016),occupation(r = 0.482),strong tea(r = 1.124),alcohol drinking(r = 0.558),meat diet(r = 0.591) and BMI(r = 0.246) were linearly correlated with GERD in Han Chinese(r = 0.786,P = 0.01).There was no significant difference between Gerd Q scoring and three normalized methods for the diagnosis of GERD.CONCLUSION:GERD is highly prevalent in adult in Urumqi,especially in Uygur.Male,civil servant,smoking,strong tea,alcohol drinking,meat diet and BMI are risk factors correlated to GERD. | Chun-Yan Niu Yong-Li Zhou Rong Yan Ni-La Mu Bao-Hua Gao Fang-Xiong Wu Jin-Yan Luo | 2012 | World Journal of Gastroenterology2012，18，48： | 17 |
| 2 | 安徽省部分地区胃食管反流病诊治状况多中心问卷调查分析显示文摘目的了解安徽省部分地区胃食管反流病(GERD)患者的发病和诊治情况。方法对合肥、蚌埠和淮南168例经反流性疾病诊断问卷(RDQ量表)拟诊为GERD的患者进行问卷调查,记录患者的基本情况和接诊医生的用药情况。结果168例患者中男性95人,女性73人,男女比例为1.3∶1;平均年龄49.6±11.9岁,以41~50岁最多,占33.9%。63.7%的患者体重正常。症状总积分12~20分的患者最多,占47.6%。性别、年龄、体重及体重指数与症状积分均无相关性。所有患者均接受了标准剂量或双倍标准剂量质子泵抑制剂(PPI)的治疗,仅有6例患者合用了其他药物治疗,PPI的疗程多在2周左右。结论安徽省部分地区GERD诊治状况与文献报道类似。 | 王亚雷 许建明 胡乃中 | 2008 | 安徽医学2008，29，4： | 4 |
| 3 | 调中颗粒对混合反流性食管炎大鼠的疗效显示文摘目的:研究调中颗粒对混合反流性食管炎大鼠食管黏膜血管活性肠肽(VIP)、P物质(SP)的水平及血浆中脂质过氧化物(MDA)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)活性的影响.方法:将大鼠随机分成5组,调中颗粒组(A组)、西沙必利组(B组)、半夏泻心汤组(C组)、正常对照组(D组)、空白模型组(E组),用食管十二指肠端侧吻合术法制备混合反流性食管炎大鼠模型,于给药2wk后处死大鼠,HE染色观察病理改变,免疫组织化学技术检测大鼠胃黏膜VIP和SP的水平,比色法检测血浆中SOD、MDA和GSH-PX的活性.结果:与E组比较,A、B、C组光镜下食管黏膜组织有不同程度的修复,平均R值分别为0.8532、0.5521、0.7865,差异显著(P<0.05),其VIP和SP表达明显增强(VIP:113.61±11.36,118.74±12.81,107.33±15.95vs91.05±10.66,P<0.05;SP:132.24±10.51,140.86±11.63,133.54±14.02vs113.73±16.37,P<0.05);MDA含量降低(4.11±0.37,4.64±0.60,4.29±0.29vs5.77±0.16,P<0.05)、SOD和GSH-PX的活性提高(SOD:431.94±21.87,402.98±36.59,384.66±46.02vs345.02±24.11,P<0.05;GSH-PX:135.83±3.71,118.26±6.34,122.78±4.76vs112.77±6.20,P<0.05).结论:调中颗粒可能通过SP和VIP表达增强来调节胃肠运动从而降低MDA的含量,提高SOD和GSH-PX的活性,抑制反流性食管炎的发展,促进黏膜的修复,从而起到抑制胃肠内容物的反流和反流性食管炎的发展的作用。 | 时昭红 张介眉 郝建军 冯云霞 陈洲 | 2008 | 世界华人消化杂志2008，16，7： | 4 |
| 4 | 体质量对反流性食管炎患者下食管括约肌压力和24h食管pH监测结果的影响显示文摘目的探讨反流性食管炎(RE)患者中,体质量对下食管括约肌压力(LESP)和24h食管pH监测结果的影响。方法对18例体质量正常RE患者和22例超重肥胖RE患者进行LESP和24h食管pH监测,对结果进行统计分析。结果超重肥胖组RE患者的LESP、pH〈4总反流时问百分比、反流时间〉5min的反流次数、总反流数、DeMeester分与体质量正常组RE患者比较,差异均有统计学意义(P均〈0.05);而超重肥胖组RE患者与体质量正常组RE患者的下食管括约肌松弛率(LESRR)比较,差异无统计学意义(P〉0.05)。结论在RE患者中,超重肥胖可影响食管动力并增加食管的酸暴露,控制体质量对治疗RE可能有一定作用。 | 吴萍 许树长 舒晓亮 陈莹 王琛 姚莉雯 | 2010 | 中华消化内镜杂志2010，，4： | 2 |
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